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Chi-Med Announces Positive Phase II Proof-of-Concept Data for,HMPL-004 in Ulcerative Colitis

ent of inflammatory bowel disease rats with HMPL-004 caused a significant drop in plasma cytokine concentrations, including TNF-? and IL-1?. Pre-clinical trails for HMPL-004 have shown the almost total restoration of the inner lining of the gut.

About Chi-Med

Chi-Med is the holding company of a pharmaceutical and healthcare group based primarily in China and was admitted to trading on the Alternative Investment Market of the London Stock Exchange in May 2006. Chi-Med is focused on researching, developing, manufacturing, and selling pharmaceuticals, health supplements and other consumer health and personal care products derived from Traditional Chinese Medicine and botanical ingredients.

Hutchison MediPharma is Chi-Med’s wholly-owned drug R&D subsidiary and has a team of around 120 scientists and staff focusing on botanical drugs, semi-synthetic natural product drugs, and synthetic single chemical entity drugs. It currently has two candidates in clinical development in both the US and China. HMPL-002, a radiosensitiser for head and neck and non-small cell lung cancer, is in Phase I/II in the US and in proof-of-concept in China. HMPL-004, an inhibitor to a group of inflammatory cytokines, has completed a Phase II proof-of-concept study in Ulcerative Colitis and is in Phase II studies in Crohn’s Disease in the US. Hutchison MediPharma also has a pipeline of single molecular entity discovery projects in auto-immune/inflammatory diseases and oncology therapeutic areas, which have shown activity against clinically validated targets.






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