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Chi-Med Announces Positive Phase II Proof-of-Concept Data for,HMPL-004 in Ulcerative Colitis

/> Yvonne Alexander
Telephone: +44 (0) 20 7638 9571

+44 (0) 7973 611 888

+44 (0) 7866 610 682

Notes to Editor

About Intestinal Bowel Disease

Ulcerative Colitis and Crohn’s Disease are forms of inflammatory bowel disease, which is considered an auto-immune disorder. They are chronic diseases which, once they start, recur regularly and cannot currently be cured. Ulcerative Colitis generally affects the large intestine and Crohn’s Disease generally affects the small intestine. Ulcerative Colitis is the inflammation of the gut, which results in extensive ulceration of its inner surface with consequential pain, loss of function and blood loss. The disease can require surgical removal of sections of the gut and, in extreme cases, it may cause death. Crohn’s Disease displays similar but more severe laceration of the lining of the small intestine.

Current first line treatments have effect on around 60% of patients. They can cause adverse events such as nausea, heartburn, diarrhea and headaches. Second line treatments can cause more severe adverse events and can be significantly more expensive.

In 2005 in the US, Ulcerative Colitis affected approximately 347,000 patients, a
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