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Cethromycin Shown Effective Against Anthrax in Study

Advanced Life Sciences Achieves Key Endpoint in Primate Study

CHICAGO, May 02, 2007 /PRNewswire-FirstCall/ -- Advanced Life Sciences Holdings, Inc. today announced that its novel respiratory antibiotic, Cethromycin, was shown to be effective in preventing inhalation anthrax infection. This conclusion was reached from a primate study where a 30-day course of oral Cethromycin was 100% protective against a lethal dose of inhaled anthrax as compared to the standard of care, Cipro(R) (ciprofloxacin), which demonstrated 90% protection.

"We felt confident going into the primate study because of Cethromycin's potent activity against over 30 strains of anthrax, yet the results have exceeded our expectations," said Dr. Michael T. Flavin, Chief Executive Officer for Advanced Life Sciences. "We believe that Cethromycin's unique antibacterial properties differentiate it from other antibiotics and, if approved by the FDA, may allow it to become a useful tool in the treatment of infections such as anthrax."

Cethromycin was recently granted Orphan Drug designation by the FDA for the prophylactic treatment of inhalation anthrax and is being developed in collaboration with U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) and the NIH's National Institute of Allergy and Infectious Disease (NIAID). Cethromycin, which has been tested in over 4,400 human subjects, is also in pivotal Phase III trials for the treatment of community acquired pneumonia (CAP). The Company expects to report data from the CAP program in June of this year.

"With emerging bacterial resistance, both natural and engineered, there is a critical need for new antibiotics that work differently than currently available therapies to protect against anthrax," continued Dr. Flavin. "To our knowledge, there are no other antibiotics in late-stage development to address this need. Based on the human safety and animal efficacy dat
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