( were measured at 12 months (p<0.05) re...)Ceregene Presents Interim Phase 1 Clinical Data of CERE-110 for the,Treatment of Alzheimer's Disease,Health

"Based on the encouraging data from this Phase 1 trial of CERE-110, we are planning a larger, controlled, Phase 2 trial that we expect to start in 2008. We are currently discussing potential collaborations for this program for the co-development of this promising therapy, CERE-110 for Alzheimer's disease," stated Jeffrey M. Ostrove, Ph.D., president and chief executive officer of Ceregene. "Similar to the other therapies in our pipeline which target Parkinson's disease and Lou Gehrig's disease, CERE-110 may have the ability to not only treat the symptoms of Alzheimer's disease but to also treat the underlying disease potentially resulting in slowed disease progression."

"Although this initial study is ongoing and we will need to wait until its completion for the final results, we believe that, to date, there are no serious safety issues with the gene expression associated with this experimental drug in our six patients with Alzheimer's disease," stated Dr. Arvanitakis.

"CERE-110 may have the potential to substantially reduce the loss of the key neuronal cells affected in patients with Alzheimer's disease. Should the clinical development of this therapy be successful, CERE-110 would offer the possibility of delaying the course of Alzheimer's disease, a real improvement over existing therapies," stated Mark Tuszynski, M.D., Ph.D., professor of neurosciences at the University of California, San Diego School of Medicine and principal investigator of an earlier Phase 1 trial of Nerve Growth Factor gene transfer in Alzheimer's Disease.

"These data add to the accumulating evidence from our studies in both humans and animals that neurotrophic factors can be delivered safely and effectively using gene transfer, thus providing the potential to restore function and slow further degeneration in many different neurodegenerative
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