Navigation Links
Cellerant Therapeutics Reversed Autoimmune Disease in Lupus Mice,with Transplant of Purified Donor Blood Stem Cells

non-ablative conditioning, which leaves the subject's immune system intact, and fully myeloablative conditioning, which eradicates the subject's immune system, prior to purified HSC treatment. Traditionally, full, and potentially lethal, myeloablative treatment was considered critical for engraftment success. The researchers found that non-ablative conditioning prior to HSC treatment was not only sufficient to ensure engraftment, but the procedure resulted in improved overall survival. The recipient subjects developed durable mixed chimerism, where the resulting immune system was a mixture of donor and recipient cells. Subjects with established autoimmune disease experienced a reversal of symptoms, including decreased appearance of proteinuria, of circulating immune complexes and of auto-antibodies to nuclear antigens.

The donors and recipients in this study were haplo-mismatched, yet successful engraftment was achieved and graft-versus-host disease (GVHD) was avoided. These results suggest that using a HCT treatment that has been purified of all or most host T cells and NK cells may eliminate the need for complete donor/patient stem cell matching. T-cells were not found to be necessary for engraftment in the procedures performed.

About HSC

Cellerant's highly purified hematopoietic (blood-forming) adult stem cells are isolated from donors or patients undergoing stem cell transplants. This process is designed to provide an improved outcome when used for stem cell transplant indications where a high level of purity is desired or required. After purification, this material contains only stem and progenitor cells, with no detectable contaminating cells such as tumor cells or the T-cells which cause graft-versus-host disease in donor-to-patient transplants. Cellerant is developing hematopoietic stem cells for cancer, genetic blood disorders and autoimmune disease.

About Lupus

Systemic lupus erythematosus (SLE), also called lupus, is an
'"/>




Page: 1 2 3

Related medicine technology :

1. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
2. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
3. CV Therapeutics Identifies Potential Anti-Diabetic Mechanism of Action for Ranexa
4. Fat Kills Cancer: Turning Stem Cells from Fat Tissue into Personalized, Cancer-Targeted Therapeutics
5. A 4-Week Therapy with Transition Therapeutics E1-I.N.T. Leads to Sustained Reductions in Blood Glucose Levels for 6 Months Post-treatment in Type 2 Diabetes Patients
6. Clinical Trial Suggests Bone Marrow Stem Cells Are Useful for Spinal Cord Injury; PrimeCell Therapeutics Provided Pre-Clinical Study
7. Opexa Therapeutics Reports Positive Top-line Data in Phase I/II Extension Trial with Tovaxin for Multiple Sclerosis
8. Orexigen Therapeutics to Present Data on Contrave Impact on Visceral Fat and Insulin Resistance at American Diabetes Association 67th Scientific Sessions in Chicago June 23
9. Allos Therapeutics Reports Results for Phase 3 Enrich Study of Efaproxyn in Women With Brain Metastases Originating From Breast Cancer
10. Trophos Publishes ALS Article in Journal of Pharmacology and Experimental Therapeutics
11. Novelos Therapeutics Announces Encouraging Results in Ongoing Phase 2 Ovarian Cancer Trial at Dana-Farber/Partners Cancer Care
Post Your Comments:
(Date:8/29/2014)... 29, 2014  United Therapeutics Corporation (NASDAQ: ... for the District of New Jersey ... case against Sandoz, Inc. regarding United Therapeutics, Remodulin ® ... ruled that U.S. Patent No. 6,765,117 is both valid ... marketing its generic product until the expiration of that ...
(Date:8/29/2014)... -- Unilife Corporation ("Unilife" or "Company") (NASDAQ: UNIS ... release its financial results for the fiscal 2014 fourth ... trading ends on Tuesday, September 9, 2014. ... p.m. U.S. EDT on Tuesday, September 9, 2014 (Wednesday, ... Company,s financial results, commercial partnerships, and future outlook.  The ...
(Date:8/29/2014)... Calif. , Aug. 29, 2014  Abaxis, Inc. ... manufacturing point-of-care blood instrumentation and consumables to the medical, ... Severson , Chairman and Chief Executive Officer, will present ... Ideas Conference 2014 on Tuesday, September 9, 2014 at ... the Omni Berkshire Place Hotel in New ...
Breaking Medicine Technology:District Court Decision Received In Remodulin Patent Case 2Unilife Corporation to Announce Financial Results for Fiscal Year 2014 Fourth Quarter and Year End on Tuesday, September 9, 2014 2Abaxis, Inc. to Present at CL King's 12th Annual Best Ideas Conference 2014 2
... Colo., Oct. 7 Waleed Danho, Ph.D., Distinguished Research ... 2009 recipient of the Meienhofer Award for excellence in ... RCCPS ( http://www.rochecolorado.com/PeptideSymp09/ ). Hosted ... Boulder, RCCPS is the only global conference exclusively dedicated ...
... Biomedical Corporation, a leading developer of whole blood analyzers, ... Sanvita CBGM, LLC, has completed the acquisition of certain ... Inc. , Nova Biomedical is the sole ... Monitoring (CBGM) subsidiary has become the exclusive distributor, of ...
Cached Medicine Technology:Roche Scientist Recognized for Excellence in Peptide Chemistry 2Roche Scientist Recognized for Excellence in Peptide Chemistry 3Roche Scientist Recognized for Excellence in Peptide Chemistry 4Subsidiary of Nova Biomedical Completes Acquisition of Assets of CCS Medical's Subsidiary, Sanvita, Inc. 2
(Date:8/30/2014)... Serving contented clients since inception, #1 web design ... is now offering discount for Labor Day on all ... putting forward the best of web development technology before ... of professionals and web developers and designers has expertise ... critical issues of web development and can develop websites ...
(Date:8/30/2014)... 2014 The federal judge overseeing ... http://www.injurybeacon.com/transvaginal-mesh/ ) filed against Boston Scientific Corp. has ... selected for one of the proceeding’s bellwether trials. ... 2014, U.S. District Judge Joseph R. Goodwin of ... Boston Scientific’s contention that a consolidated trial would ...
(Date:8/30/2014)... Transvenous lead extraction (TLE) is clinically successful in more ... European Lead Extraction ConTRolled (ELECTRa) registry presented for the ... Maria Grazia Bongiorni, chair of the registry,s executive committee. ... electronic devices (CIED) implant procedures has grown in recent ... has increased and leads are often the cause. TLE ...
(Date:8/30/2014)... OK (PRWEB) August 30, 2014 In ... valuable, and increasingly difficult to get. Snoring and sleep ... sleep and breathing stops) robs people and their bed ... daily challenges. Up to 45% of the population snores ... have sleep apnea. Of these, only 10% have been ...
(Date:8/30/2014)... Top10BestSEOHosting.com is a well-known review website. Recently, the ... http://secure.hostgator.com/~affiliat/cgi-bin/affiliates/clickthru.cgi?id=seohosts is the best Windows Hosting supplier ... that Bluehost and Arvixe are excellent companies for ... Top 10 Web Hosting in 2014, is a ... offers rich features and great Windows hosting solutions ...
Breaking Medicine News(10 mins):Health News:Profit By Outsourcing Offering Discount for Labor Day on all Web Development Services 2Health News:Transvaginal Mesh Lawsuit News: Federal Judge Refuses Boston Scientific Request for Separate Trials in Four Bellwether Cases, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuit News: Federal Judge Refuses Boston Scientific Request for Separate Trials in Four Bellwether Cases, Bernstein Liebhard LLP Reports 3Health News:Transvenous lead extraction clinically successful in 98 percent of cases 2Health News:Transvenous lead extraction clinically successful in 98 percent of cases 3Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:Top10BestSEOHosting.com: HostGator.com Is The Best Windows Hosting Supplier 2
... available in German . The stomach bacterium ... the development of gastric cancer, the third most common cause of ... Zurich have now identified a mechanism of Helicobacter pylori that damages ... up for malignant transformation. Gastric cancer is one of the ...
... Do sexualized lyrics in popular music have an impact on ... Joshua H. West, and Shane Hill from Brigham Young University ... increasing use of sexually explicit lyrics in music. Their ... , provide food for thought for educators whose focus is ...
... Academy of Sciences and the Global Medical Excellence Cluster ... College London, will host a two-day scientific conference, ... and Toxicity," that will provide a forum to ... drug discovery. Areas of focus include: how do animal ...
... published study by researchers at Columbia University,s Mailman School ... effects on children of a group of ubiquitous chemicals ... that are known to disrupt the endocrine system, and ... toys, to household building materials, to shampoos. Recent ...
... News) -- Mild cognitive impairment -- marked by a ... a stronger predictor of Alzheimer,s disease than so-called "biomarkers," ... or levels of certain proteins in cerebrospinal fluid, a ... people with mild cognitive impairment (MCI) who developed Alzheimer,s ...
... French . , A major landmark study released ... light on the state of Europe,s mental and neurological health. ... largest health challenge in the 21st century. The study also ... together with the large and increasing number of ,disorders of ...
Cached Medicine News:Health News:Stomach bacterium damages human DNA 2Health News:Songs about sex - how they affect kids 2Health News:New York Academy of Sciences and GMEC host forum on value of animal models in drug discovery 2Health News:New York Academy of Sciences and GMEC host forum on value of animal models in drug discovery 3Health News:Prenatal exposure to phthalates linked to decreased mental and motor development 2Health News:Short-Term Memory Loss May Be Best Predictor of Alzheimer's 2Health News:The size and burden of mental disorders in Europe 2Health News:The size and burden of mental disorders in Europe 3
Titanium. Curved shafts with 5.5 mm tying platform. Round knurled handle with dull finish. Overall length 4.3 inches....
Angled 45 degree shafts 8 mm from tip to bend with 5 mm tying platform. Serrated handle with dull finish. Overall length 3.3 inches....
Angled 45 degree shafts 8 mm from tip to bend with 4 mm tying platform. Smooth handle with dull finish. Overall length 3.2 inches....
Straight shafts with 4 mm tying platform. Wide serrated handle with dull finish. Overall length 4.3 inches....
Medicine Products: