Navigation Links
Cellerant Therapeutics Reversed Autoimmune Disease in Lupus Mice,with Transplant of Purified Donor Blood Stem Cells

SAN CARLOS, Calif.--(BUSINESS WIRE)--Apr 23, 2007 - Cellerant Therapeutics today announced the publication of data suggesting that established autoimmune disease can be reversed or stabilized by the transplantation of purified allogeneic (donated) hematopoietic (blood forming) stem cells (HSC) in a mouse study of Systemic Lupus Erythematosus (SLE). Subjects that underwent this procedure exhibited improved overall survival and decreased lupus symptoms. The research, led by Dr. Julie Christensen with colleagues from Cellerant and Stanford University, was published on April 13, 2007 as a First Edition Paper in the online version of the American Society of Hematology's journal, BLOOD (Smith-Berdan et. al., DOI 10.1182/BLOOD-2007-03-081497).

"The demonstration of successful reversal of the disease using purified stem cells with non-myeloablative conditioning offers a novel strategy to treat autoimmune diseases such as lupus with decreased morbidity," said Ramkumar Mandalam, Ph.D., Vice President of Pharmaceutical Operations. "This study also provides further support for our belief that purified stem cells may make it possible to use un-matched donors, such as a parent or non-identical sibling, for a variety of HSC treatment procedures."

"The publication of this preclinical data further validate Cellerant's unique use of pure hematopoietic stem cells for a wide range of therapeutic applications, including lupus and other autoimmune disorders, as well as for cancer and blood disorders," commented Bruce Cohen, Cellerant's President and CEO. "This finding is consistent with recent reports on successful use of hematopoietic stem cell transplantation for the treatment of autoimmune diseases and merits evaluation of pure stem cells in treating such diseases."

Cellerant researchers worked with specialized mice that are prone to an autoimmune condition that closely resembles human SLE. The study evaluated both non-ablative conditioning, which leaves the subject's immune system intact, and fully myeloablative conditioning, which eradicates the subject's immune system, prior to purified HSC treatment. Traditionally, full, and potentially lethal, myeloablative treatment was considered critical for engraftment success. The researchers found that non-ablative conditioning prior to HSC treatment was not only sufficient to ensure engraftment, but the procedure resulted in improved overall survival. The recipient subjects developed durable mixed chimerism, where the resulting immune system was a mixture of donor and recipient cells. Subjects with established autoimmune disease experienced a reversal of symptoms, including decreased appearance of proteinuria, of circulating immune complexes and of auto-antibodies to nuclear antigens.

The donors and recipients in this study were haplo-mismatched, yet successful engraftment was achieved and graft-versus-host disease (GVHD) was avoided. These results suggest that using a HCT treatment that has been purified of all or most host T cells and NK cells may eliminate the need for complete donor/patient stem cell matching. T-cells were not found to be necessary for engraftment in the procedures performed.

About HSC

Cellerant's highly purified hematopoietic (blood-forming) adult stem cells are isolated from donors or patients undergoing stem cell transplants. This process is designed to provide an improved outcome when used for stem cell transplant indications where a high level of purity is desired or required. After purification, this material contains only stem and progenitor cells, with no detectable contaminating cells such as tumor cells or the T-cells which cause graft-versus-host disease in donor-to-patient transplants. Cellerant is developing hematopoietic stem cells for cancer, genetic blood disorders and autoimmune disease.

About Lupus

Systemic lupus erythematosus (SLE), also called lupus, is an autoimmune disorder characterized by the immune system attacking the body's own tissues and organs, leading to inflammation and damage. The severity of the disease varies, from mild cases only involving the skin to severe cases affecting multiple organs, including the brain. Lupus sufferers experience flares, or intervals of active disease, and remissions in disease. The disease most predominantly occurs in women of childbearing age, but also affects children, adolescents, and men. While the cause of lupus is still unknown, various genetic, environmental, and infectious causes have been associated with its development. Current treatments for lupus vary depending on the extent of the disease, and may change over time. Some medications used to ease symptoms include nonsteroidal anti-inflammatory drugs, antimalarial drugs, corticosteroids, and immunosuppressive medications, though many of these drugs carry their own risks.

About Cellerant

Cellerant Therapeutics is a commercial-stage company developing a portfolio of products and services focused on the regulation of the hematopoietic (blood-forming) system. Our products are based on adult hematopoietic stem and progenitor cells as both therapeutic agents and targets for drug discovery. Visit our website at http://www.cellerant.com.

Contact

Cellerant Therapeutics, Inc.
Bruce Cohen, 650-232-2122
or
MacDougall Biomedical Communications
Kari Watson, 508-647-0209
kari@macbiocom.com


'"/>




Related medicine technology :

1. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
2. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
3. CV Therapeutics Identifies Potential Anti-Diabetic Mechanism of Action for Ranexa
4. Fat Kills Cancer: Turning Stem Cells from Fat Tissue into Personalized, Cancer-Targeted Therapeutics
5. A 4-Week Therapy with Transition Therapeutics E1-I.N.T. Leads to Sustained Reductions in Blood Glucose Levels for 6 Months Post-treatment in Type 2 Diabetes Patients
6. Clinical Trial Suggests Bone Marrow Stem Cells Are Useful for Spinal Cord Injury; PrimeCell Therapeutics Provided Pre-Clinical Study
7. Opexa Therapeutics Reports Positive Top-line Data in Phase I/II Extension Trial with Tovaxin for Multiple Sclerosis
8. Orexigen Therapeutics to Present Data on Contrave Impact on Visceral Fat and Insulin Resistance at American Diabetes Association 67th Scientific Sessions in Chicago June 23
9. Allos Therapeutics Reports Results for Phase 3 Enrich Study of Efaproxyn in Women With Brain Metastases Originating From Breast Cancer
10. Trophos Publishes ALS Article in Journal of Pharmacology and Experimental Therapeutics
11. Novelos Therapeutics Announces Encouraging Results in Ongoing Phase 2 Ovarian Cancer Trial at Dana-Farber/Partners Cancer Care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... 22, 2017  Corin Group announced today the launch ... to treat patients with both a massive rotator cuff ... condition, known as cuff tear arthropathy, causes pain and ... The Humelock Reversed Shoulder System, which was developed ... based near Lyon, France , received ...
(Date:2/22/2017)... and PUNE, India , February 22, ... Allied Market Research, titled, "Automated Radio Synthesis Modules Market: Global ... automated radiosynthesis modules market was worth $20 million in 2015 ... a CAGR of 6.6% from 2016 to 2022. ... terms of both market revenues and unit volumes, whereas ...
(Date:2/22/2017)... --  Known for selling everyday household products commonly found ... California urologist Dr. Ron ... the British conglomerate that makes those products – it ... her late husband,s invention, business plans, and other trade ... until his violent death in 2013, filed suit yesterday ...
Breaking Medicine Technology:
(Date:2/22/2017)... ... February 22, 2017 , ... ... to Quality Insights to help small practices in Delaware, New Jersey, Pennsylvania and ... by the Medicare Access and CHIP Reauthorization Act of 2015 (MACRA). , ...
(Date:2/22/2017)... ... 22, 2017 , ... Michael J. Hennessy Associates, Inc. (MJH ... technology professionals and other key stakeholders with an array of valuable resources, Healthcare ... 1, announced Michael J. Hennessy, Jr., president of MJH Associates. , In ...
(Date:2/22/2017)... ... 22, 2017 , ... Pet obesity in the U.S. continued to steadily increase ... Association for Pet Obesity Prevention (APOP). During the ninth annual survey, APOP also found ... benefits of corn and grains, value of raw and organic diets, and the best ...
(Date:2/22/2017)... , ... February 22, 2017 , ... ... Yet with so many different solutions on the market, it is easy to ... Texas Premier Locksmith offers a complimentary security consultation. , Home Security ...
(Date:2/22/2017)... - NORTHERN CALIFORNIA (PRWEB) , ... February 22, ... ... to expand the pipeline and the number of African American/Black students who want ... students and residents to pursue their careers as physicians in the Oakland/San Francisco ...
Breaking Medicine News(10 mins):