Navigation Links
CeNeS Pharmaceuticals plc: Update on Successful Phase III results,announced on Lead Product M6G

Further analysis of Phase III trial data underlines M6G's benefit compared to morphine in the treatment of post-operative pain

CAMBRIDGE, England, 7th March 2007 - CeNeS Pharmaceuticals plc (AIM: CEN), the Cambridge based biopharmaceutical company today announces additional data from the pivotal Phase III trial (M6G022) of M6G (morphine-6-glucuronide) in over 500 patients with post-operative pain. The preliminary data released on 20th February showed that M6G provided equivalent pain relief to morphine but induced significantly less post-operative nausea and vomiting (PONV).

Secondary Data Results

The additional secondary data now received by CeNeS shows that:

* less anti-emetic drugs (drugs used to control nausea and vomiting) were required in patients treated with M6G compared with those on morphine; and * M6G exhibited a long duration of analgesic action.

This was the first Phase III study where patients were given a complete pain management programme with M6G (rapid titration to comfort followed by PCA for up to 48 hours) and the first Phase III trial where nausea and vomiting were assessed as primary endpoints.

Management of PONV/use of anti-emetics

In addition to the clear nausea and vomiting reductions of over 25% announced last week, secondary data reveals that patients receiving M6G required over 20% less anti-emetic medication over the 0-24 hour period than those in the morphine group. This shows that not only does M6G induce significantly less nausea and vomiting than morphine, but also that the post-operative anti-emetic treatment required is considerably reduced.

The potential for reduced anti-emetic drug costs combined with the reduction in medical assistance and the improved patient comfort due to lower PONV supports CeNeS justification of a substantial price premium for M6G compared to morphine.

Drug consumption

It has been sh
'"/>




Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Major New Review Supports the Broader Potential of CeNeS COMT Inhibitor Discovery Programme
2. Independent publication supports the profile of CeNeS phase II compound, CNS 5161
3. CeNeS Pharmaceuticals Plc Announces Preliminary Results for The Year Ending 31 December 2006
4. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
5. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
6. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
7. Auxilium Pharmaceuticals to Present at the 2007 CEUT Emerging Growth Opportunities Conference
8. Sunesis Pharmaceuticals to Present at the C. E. Unterberg, Towbin Emerging Growth Conference
9. EPIX Pharmaceuticals to Present at the C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
10. Pro-Pharmaceuticals Updates Progress of Clinical Trials & Davanat 505 (b)(2) Filings
11. Cosmo Pharmaceuticals Reports Positive Preliminary Phase II/III Data with Rifamycin MMX in Infectious Diarrhea
Post Your Comments:
(Date:1/15/2014)... , January 15, 2014 BreedIT Corp ... exclusive worldwide distributor of highly sophisticated agro-breeding solutions for ... 7, 2014, the Company,s board of directors appointed chemistry ... as its new member of the board. ...
(Date:1/15/2014)... , Jan. 15, 2014 Tegra Medical is very ... King as its new Chief Executive Officer.  Mark was ... which he has overseen the company,s four facilities in ... Costa Rica.  Mr. King joined Tegra Medical in 2012 with ...
(Date:1/15/2014)... 2014 The Cadence Fitness & Health Center has ... Medical Fitness Association, a non-profit organization assisting medically integrated ... The Cadence Fitness & Health Center is the only ... in the Chicagoland area. "The certification means ...
Breaking Medicine Technology:BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3
... N.J., Dec. 9, 2011 The Dr. Paul Janssen ... call for nominations. This prestigious award recognizes individuals ... potential to make, significant transformational contributions toward the ... www.pauljanssenaward.com and will be accepted until February ...
... of 94.4 out of 100, Elekta,s Leksell Gamma Knife® Perfexion™ ... among six advanced radiation therapy systems, according to KLAS research ... Dose of New Technology . The Elekta Infinity™ radiation ... of 84.4, improving its score over the 2010 report. ...
Cached Medicine Technology:Dr. Paul Janssen Award for Biomedical Research Issues Call for Nominations 2Dr. Paul Janssen Award for Biomedical Research Issues Call for Nominations 3Dr. Paul Janssen Award for Biomedical Research Issues Call for Nominations 4Elekta's Leksell Gamma Knife Perfexion Earns Nearly Perfect Score in 2011 KLAS Radiation Therapy Report 2
(Date:7/10/2014)... to bump up their grade point averages during college, ... a library or study hall, but in a gym. ... who were members of the recreational sports and fitness ... years had higher GPAs than those who weren,t. ... stayed in school longer. An increase of 3.5 percent ...
(Date:7/10/2014)... severe illness and even death are likely to result ... influenza. Now, however, a team of researchers based at ... the order of infection, the bacteria Streptococcus pneumoniae ... bad case of the flu. , The researchers ... as a bacterial virulence factor, might protect macrophagesa type ...
(Date:7/10/2014)... more likely to be diagnosed with more aggressive ... for shorter times than prostate cancer patients who ... , The negative outcomes may be the result ... mentally ill, depression,s impact on biological cancer processes, ... general health and disinterest in receiving more effective ...
(Date:7/10/2014)... 10, 2014) Men who experience hot flashes are ... find relief from their silent suffering if they ... findings from a Baylor University case study., After seven ... had uncontrolled hot flashes following prostate cancer surgery showed ... also an impressive improvement in sleep quality, according to ...
(Date:7/9/2014)... time, researchers have access to detailed information about how ... A new study, called Our Health Counts, uses this ... by urban Aboriginal people in Canada according to ... published today in BMJ Open , illustrate striking ... population. , Researchers interviewed 554 First Nations adults in ...
Breaking Medicine News(10 mins):Health News:Want a higher GPA in college? Join a gym 2Health News:Bacterial colonization prior to catching the flu may protect against severe illness 2Health News:Depressed men with prostate cancer are diagnosed later stage, get less effective therapies 2Health News:Men's hot flashes: Hypnotic relaxation may ease the discomfort men don't talk about 2Health News:Men's hot flashes: Hypnotic relaxation may ease the discomfort men don't talk about 3Health News:Men's hot flashes: Hypnotic relaxation may ease the discomfort men don't talk about 4Health News:Urban Aboriginal people face unique health challenges 2
... confirms that hormone replacement therapy (HRT) should not be prescribed ... help prevent chronic conditions such as heart disease . ... safe short term treatment for younger women in early menopause ... ,In 2002, the Womens Health Initiative (WHI) trial found that ...
... have, the slower you age . ,Researchers at ... moles in a study of 1,800 twins, at the Twin Research Unit ... the more likely their DNA was to have the properties to fight ... in spite of the fact that moles are linked with ...
... 13 million kilograms of antibiotics are used to raise ... are used for growth advancement and disease prevention ... up as manure, which is commonly applied to agricultural ... on manure-altered soils are exposed to antibiotics. , ...
... Thiruvananthapuram Zoo has barred the entry of visitors for a week ... reportedly lost its entire stock of Indian gaur (Bos Gaurus) -- ... the week gone by. ,It was confirmed last ... the death of animals. ,The zoo was being ...
... to a particular variety of sugar present on the surface ... are regarded as mindless killers. White blood cells (WBC) form ... our internal body. They protect our body from various kinds ... wiping out any intruder that invades the body. A new ...
... she feared that her recent miscarriage was god's way of punishing ... lost her baby when she was three months pregnant, said that ... of this year, she thought she would never recover after losing ... is all this happening?' I thought it was God's punishment for ...
Cached Medicine News:Health News:Study Confirms No HRT Benefit for Older Women 2Health News:Study Confirms No HRT Benefit for Older Women 3Health News:Dotted All Over? - Count Yourself Lucky 2Health News:Contamination of the Environment by Antibiotics Fed to Livestock 2Health News:WBC Selective About Sugar 2
... The Finnpipette BioControl multichannel ... features as the single ... handle fits allseven multichannel ... tip cone modules. Both ...
... Research pro Electronic Pipette is ideal for ... Its easy-to-follow display, ergonomically-placed operating buttons, and ... reverse pipetting and diluting make this a ... functions of a manual pipette without any ...
... Unparalleled Comfort Pick one of our pipettors ... the trigger and ejector positionsright where they should ... are ergonomically designed to help avoid repetitive stress ... Productivity In The Palm Of Your Hand ...
... best value in high performance electronic pipetting!, ... lightweight design reduce hand fatigue and strain ... tip ejector , Color coding for easy ... for greater performance use Hamilton AdvanTip Low ...
Medicine Products: