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CeNeS Pharmaceuticals Plc Announces Preliminary Results for The,Year Ending 31 December 2006

ting are the most common. Post operative nausea and vomiting ('PONV') is rated among patients as one of the most distressing after-effects of surgery and reduces their quality of life.

The active potent metabolite of morphine, morphine-6-glucuronide (M6G), offers therapeutic advantages over morphine in having an equivalent analgesic effect, but with a reduced tendency to cause nausea, vomiting and respiratory depression. Phase II and III clinical trials have shown that M6G given intravenously produces equivalent analgesia to morphine to combat post-operative pain. Studies have also shown that M6G reduced the incidence of nausea and vomiting when compared directly with morphine. Other studies published in the scientific literature demonstrate that M6G also induces less respiratory depression compared to morphine.

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http://hugin.info/137021/R/1114941/203337.pdf

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