( or toxicity. Treatment withGuanilib d...)Callisto Intends to Move Guanilib into Clinical Trials in,Ulcerative Colitis,Health

or toxicity. Treatment with Guanilib down-regulated production of IL-17 by 50%, IL-23 by 70% and TNF by 50% in addition to showing reduction of other cytokines including IL-4 and IL-5. Recent data on IBD suggest that proinflammatory IL-17 and IL-23 play major roles in the pathophysiology of this disease as well as irritable bowel syndrome [SCIENCE 314(5804):1461-1463, 2006].

About Guanilib

Guanilib, also known as SP304, is an orally deliverable compound designed to mimic a naturally-occurring hormone called uroguanylin which is normally produced in the body's intestinal tract. Deficiency of this hormone is predicted to be one of the primary reasons for the formation of polyps that can lead to colon cancer, as well as debilitating and difficult-to-treat GI inflammatory disorders such as ulcerative colitis and Crone's disease.

About Inflammatory Bowel Disease (IBD)

The inflammatory bowel diseases Crohn's disease and ulcerative colitis are common, chronic disorders that cause abdominal pain, diarrhea, and gastrointestinal bleeding. Recent data also suggest that irritable bowel syndrome is a low-grade IBD. More than 500,000 Americans are afflicted with ulcerative colitis, a type of inflammatory bowel disease (IBD) that causes chronic inflammation of the digestive tract. Along with Crohn's disease, the other major form of IBD, ulcerative colitis can be painful and debilitating, and can lead to other serious and life-threatening complications. There is currently no medical cure for ulcerative colitis.

About Callisto Pharmaceuticals, Inc.

Callisto is a biopharmaceutical company focused on the development of new drugs to treat various forms of cancer and other serious afflictions. Callisto's drug candidates in development currently include anti-cancer agents in clinical development, in addition to drugs in pre-clinical development for other significant health care markets, including ulcerative colitis. One of the Company's lead dru
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