Navigation Links
Calando Pharmaceuticals Publishes the First Non-Human Primate Study,on Targeted, Systemic Delivery of siRNA in National Academy of,Sciences Journal

PASADENA, Calif.--(BUSINESS WIRE)--Mar 20, 2007 - Calando Pharmaceuticals, a leading siRNA therapeutics company and a majority-owned subsidiary of Arrowhead Research Corporation (NASDAQ: ARWR) announced the publication in the Proceedings of the National Academy of Sciences (PNAS), the scientific journal of the NAS, of the first non-human primate study to use multiple, systemic dosing with Calando's lead siRNA therapeutic candidate that is a nanoparticle containing non-chemically modified siRNA and a transferrin protein targeting agent.

The paper, entitled "Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA," was published online in the Early Edition of the PNAS. This paper details the results of a pilot safety study of Calando's lead siRNA-containing nanoparticle formulation (CALAA-01) in monkeys. In this dose-escalation experiment, systemically-administered nanoparticles were well-tolerated at doses significantly above those that had been previously shown to be efficacious with a similar formulation in murine cancer models. Overall, this study shows that multiple, systemic doses of CALAA-01 can safely be administered to non-human primates, and is the first example of multiple systemic dosing of siRNA in monkeys.

The formulation investigated contains Calando's proprietary delivery technology with a non-chemically modified siRNA duplex targeting the M2 subunit of ribonucleotide reductase, a well-established cancer target. This duplex, developed by Calando, demonstrates potent anti-proliferative activity across multiple types of cancer in vitro and in vivo. The objective of this escalating-dose pilot study was to assess numerous safety-related parameters for this formulation in non-human primates since it is known that proper evaluation of complement activation is best performed in this type of animal prior to
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Calando Pharmaceuticals Announces Preclinical Efficacy and Safety Data of Targeted, Systemic Delivery of siRNA at AACR Annual Meeting
2. Arrowhead Subsidiaries Insert & Calando Present Data on Cyclosert Drug Delivery System at AACR Meeting
3. Arrowhead Subsidiary Calando Pharmaceuticals Publishes Study Showing Anti-Cancer Effect with Lead RNAi Candidate
4. Calando Pharmaceuticals Publishes Study Showing Anti-Cancer Effect with Lead RNAi Candidate
5. Arrowhead Subsidiary, Calando Pharmaceuticals Publishes Study on Targeted, Systemic Delivery of siRNA
6. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
7. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
8. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
9. Auxilium Pharmaceuticals to Present at the 2007 CEUT Emerging Growth Opportunities Conference
10. Sunesis Pharmaceuticals to Present at the C. E. Unterberg, Towbin Emerging Growth Conference
11. EPIX Pharmaceuticals to Present at the C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
Post Your Comments:
(Date:8/4/2015)... BETHLEHEM, Pa. , Aug. 4, 2015 ... takes prescription medications, yet only half of consumers surveyed ... 18 percent have ever used use them, according to ... FamilyWize , a community service partnership focused on improving ... The online survey polled 1,000 men and ...
(Date:8/3/2015)... WEST JORDAN, Utah , Aug. 3, 2015  BC ... Solutions has acquired Ohio Valley Medical Systems, one of ... MRI systems.  The addition of Ohio Valley Medical Systems ... to now include Hitachi MRI.   "We ... Mark Alvarez , President and CEO of BC Technical. ...
(Date:8/3/2015)... Calif., Aug. 3, 2015 AcelRx Pharmaceuticals, Inc. ... on the development and commercialization of innovative therapies for ... update and reported financial results for the three and ... highlights include: , On July 23, 2015, the ... a positive opinion for Zalviso™ for the management of ...
Breaking Medicine Technology:New Study Finds Consumers are Leaving Money at the Pharmacy 2New Study Finds Consumers are Leaving Money at the Pharmacy 3BC Technical Acquires Ohio Valley Medical Systems 2AcelRx Pharmaceuticals Provides Business Update and Reports Second Quarter and Six Months 2015 Financial Results 2AcelRx Pharmaceuticals Provides Business Update and Reports Second Quarter and Six Months 2015 Financial Results 3AcelRx Pharmaceuticals Provides Business Update and Reports Second Quarter and Six Months 2015 Financial Results 4AcelRx Pharmaceuticals Provides Business Update and Reports Second Quarter and Six Months 2015 Financial Results 5AcelRx Pharmaceuticals Provides Business Update and Reports Second Quarter and Six Months 2015 Financial Results 6AcelRx Pharmaceuticals Provides Business Update and Reports Second Quarter and Six Months 2015 Financial Results 7AcelRx Pharmaceuticals Provides Business Update and Reports Second Quarter and Six Months 2015 Financial Results 8AcelRx Pharmaceuticals Provides Business Update and Reports Second Quarter and Six Months 2015 Financial Results 9AcelRx Pharmaceuticals Provides Business Update and Reports Second Quarter and Six Months 2015 Financial Results 10
... American Association of,Health Freedom and the International ... the Baromedical Research,Institute and Louisiana State University ... successful treatment of chronic traumatic brain injury,(TBI). ... Oct 12;1174:120-9),are purportedly the first-ever demonstration of ...
... Oct. 10 Face,transplants, once on the fringe ... new estimates that suggest the risk of tissue,rejection ... a recent,review in Plastic and Reconstructive Surgery(R) (PRS), ... Plastic Surgeons (ASPS)., "We can only know ...
Cached Medicine Technology:Researchers Report First Successful Treatment of Chronic Traumatic Brain Injury 2Risks Associated With Face Transplants May Be Lower Than Previously Thought, ASPS Journal Review Suggests 2
(Date:8/4/2015)... ... August 04, 2015 , ... Members receiving care from a doctor ... at a cost that is nine percent lower -- than those members at traditional ... New Jersey’s patient-centered programs. , “The promise of patient-centered, or value-based, care to ...
(Date:8/4/2015)... ... 04, 2015 , ... Increasingly, patients are researching online to ... In an effort to share more and better information with these savvy and ... share patient satisfaction ratings and comments about its doctors and advanced practice providers. ...
(Date:8/4/2015)... ... August 04, 2015 , ... ... examination now offered by the world renowned Beverly Hills facelift surgeon , ... through cosmetic surgery techniques helps individuals to achieve an outer appearance that meets ...
(Date:8/4/2015)... ... August 04, 2015 , ... Providigm, LLC, a ... facilities, today announced details of the Advanced level of their national accreditation for ... QAPI Accreditation program , introduced in 2013, is based on standards for ...
(Date:8/4/2015)... ... August 04, 2015 , ... ... personal health record (PHR) product has achieved Office of the National Coordinator ... Certification from Drummond Group. HealthCenter delivers the highest quality personal health record ...
Breaking Medicine News(10 mins):Health News:Horizon BCBSNJ: 2014 Results Show Patient-Centered Care Continues to Deliver on Promise of Better Quality Care at a Lower Cost 2Health News:Horizon BCBSNJ: 2014 Results Show Patient-Centered Care Continues to Deliver on Promise of Better Quality Care at a Lower Cost 3Health News:UPMC 1st in Pa. to Share Provider Ratings 2Health News:UPMC 1st in Pa. to Share Provider Ratings 3Health News:Beverly Hills Surgeon, Dr. Paul Nassif, is Now Offering Personal Consultations with Full Examinations for Facial Plastic Surgeries 2Health News:Beverly Hills Surgeon, Dr. Paul Nassif, is Now Offering Personal Consultations with Full Examinations for Facial Plastic Surgeries 3Health News:Nursing Homes Achieving New Advanced Accreditation See Improved Measures of Quality, Better Occupancy Rates 2Health News:Nursing Homes Achieving New Advanced Accreditation See Improved Measures of Quality, Better Occupancy Rates 3Health News:MedicaSoft's HealthCenter Earns ONC-HIT Certification from Drummond Group 2Health News:MedicaSoft's HealthCenter Earns ONC-HIT Certification from Drummond Group 3
... News) -- The prevalence of psoriasis -- a chronic, inflammatory ... and obese kids, researchers have found. The Kaiser ... , also found that teens with psoriasis (regardless of their ... risk for heart disease. "This study suggests a ...
... 20 (HealthDay News) -- For the average listener, the ... speaker,s sexual orientation, a new study finds. "I,m not ... vowel," study lead author Erik C. Tracy, a cognitive psychologist ... the American Institute of Physics. "Other researchers have done various ...
... , FRIDAY, May 20 (HealthDay News) -- All ... to 11 years old, according to new guidelines from the ... with a family history of premature cardiovascular disease or elevated ... as early as age 2. "It,s important that people ...
... Dr. Jeffrey M. Trent, F.A.C.M.G., a nationally recognized ... has been appointed Foreign Trade Counselor of Luxembourg in ... and Research Director of the Translational Genomics Research Institute ... Grand Rapids, Michigan. Both non-profit biomedical research institutes study ...
... News) -- Though a new study suggests that a dietary ... develop preeclampsia, the jury is still out over whether it ... it yet. Preeclampsia is a pregnancy complication ... hypertension. It affects about 5 percent of first pregnancies. ...
... SESSION I / Monday, May 23 / 8 ... Acute Coronary Syndrome Patients in Real World Clinical Practice: Observations ... Bhandary D2, Stephenson JJ1, Gold A2, Fu AC1, Kern DM1, ... SESSION II / Tuesday, May 24 / 8 ...
Cached Medicine News:Health News:Study Sees Link Between Psoriasis, Obesity in Kids 2Health News:Straight or Gay? Vowels in Speech May Give it Away 2Health News:Experts Say Cholesterol Screenings Should Start in Childhood 2Health News:TGen/VARI president Dr. Jeffrey Trent appointed Foreign Trade Counselor by Luxembourg 2Health News:Study Suggests Supplement May Protect Against Preeclampsia 2Health News:HealthCore presents ISPOR poster sessions 2
... just about everything imaginable that might have to ... is designed for long term storage under archival ... over metal systems is overlooked, while the natural ... of desiccator and insulator, providing an environment that ...
A prepared Microscope Slide Cataloging and Storage System....
... Our moisture resistant, plastic covered ... high, each supporting up to 500 ... weight. Each box accommodates 2000 slides ... your varied storage requirements. Come unassembled ...
Shandon Plastic Slide Boxes...
Medicine Products: