Navigation Links
CSL Therapy That Mimics 'Good' Cholesterol May Reduce Plaque Volume,in Coronary Arteries

NEW ORLEANS, March 26, 2007 /PRNewswire/ -- CSL Limited today announced results from a study published in the Journal of the American Medical Association that suggest infusions of a novel new drug, CSL-111, to acutely raise HDL ("good" cholesterol) levels, may reduce the amount of plaque in the coronary arteries of patients with a recent episode of acute coronary syndrome (ACS).

ACS is the term used to describe unstable angina and myocardial infarction (heart attack). It is estimated to be responsible for up to 600,000 admissions to the hospital per year in the US. Despite improvements in management over many years, ten to fifteen percent of patients still experience a serious cardiovascular problem in the 12 months following an episode of ACS.

CSL-111 is a patented biologic product, consisting of apolipoprotein A-I purified from human plasma that is reconstituted to form a particle that chemically and biologically resembles human HDL. A 40 mg/kg dose of CSL-111 results in an approximately 50 percent elevation in blood HDL levels, which remain above normal for one week. It was discovered and is manufactured at CSL Behring in Switzerland.

The Effect of Reconstituted HDL on Atherosclerosis - Safety and Efficacy (ERASE) trial was a phase 2, randomized, blinded, placebo-controlled study conducted at 17 sites throughout Canada and coordinated by the Montreal Heart Institute. The trial examined whether four infusions of CSL-111, given at weekly intervals to patients with a recent episode of ACS, could reduce the volume of plaque in the coronary arteries. Assessment of the arteries was performed using intravascular ultrasound (IVUS) and quantitative coronary angiography (QCA) before and two-three weeks after the treatment. IVUS is a technique in which a tiny ultrasound probe is inserted into the coronary arteries to determine the change in plaque during treatment. Coronary angiography is an X-ray
'"/>




Page: 1 2 3 4

Related medicine technology :

1. Gene Chips to Detect CYP Variations: A New Step Toward Customized Medical Therapy.
2. Breast Cancer and HER-2/neu: Diagnostic Tools for Targeted Therapy
3. Pixantrone Combination Therapy for First-line Treatment of Aggressive Non-Hodgkins Lymphoma Results in Reduction in Severe Toxicities Including Heart Damage When Compared to Doxorubicin-based Therapy
4. Gene Therapy Eradicates Pancreatic Cancer in Preclinical Trial Targeting Systems Success in Mouse Model Reported in Cancer Cell
5. Response Genetics Announces Publication of a Phase III Clinical Trial Demonstrating That Low Levels of ERCC-1 Help to Predict Likelihood of Response to Cisplatin-Based Therapy in Lung Cancer
6. New Phase 3 Study Published in The Lancet Evaluates Efficacy and Safety of Prezista/Ritonavir vs. Kaletra as Part of HIV Combination Therapy in Treatment-Experienced Adults With HIV
7. Lexicon Develops Antibodies That Lower Triglycerides and Cholesterol as Potential New Therapy for Heart Disease
8. Studies of Drug Resistance May Lead to Individual Therapy for Rare Cancers
9. Velcade (bortezomib) for Injection Based Induction Therapy Delivered High Post-Transplant Complete Remission Rate, a Critical Marker for Increased Overall Survival
10. A 4-Week Therapy with Transition Therapeutics E1-I.N.T. Leads to Sustained Reductions in Blood Glucose Levels for 6 Months Post-treatment in Type 2 Diabetes Patients
11. An Investigational Study Released at ADA Showed that Initial Combination Therapy with Januvia (sitagliptin) and Metformin Led to Improvement in Markers of Beta Cell Function in Patients with Type 2 Diabetes
Post Your Comments:
(Date:7/30/2014)... , July 30, 2014 Silicon Valley Bank, ... a study today that examines the merger, acquisition ... device companies.  According to the annual report based on ... potential returns since SVB started tracking the data in ... IPO.  Built on solid healthcare M&A activity over the ...
(Date:7/30/2014)... NEW YORK , July 30, 2014 ... products for oncology supportive care, announced that its novel ... featured in an article on OncLive.com titled, "Study Finds ... Neck Cancers."  Dr. Steve Sonis , a leading ... demand seen in the oncology community for evidence-based strategies ...
(Date:7/30/2014)...   Medical Equipment Solutions, Corp. are pleased ... of Defense (US Army) contract valued at over $2 ... diagnostic machine and technical support staffing. As an 8-A ... Business Administration (SBA), Medical Equipment is proud to support ... medical diagnostic equipment. The SBA 8-A certification is a ...
Breaking Medicine Technology:Report: Biopharma and Medical Device Companies Beat Historic Investment Returns 2Report: Biopharma and Medical Device Companies Beat Historic Investment Returns 3Access Pharmaceuticals Featured On OncLive.com 2Access Pharmaceuticals Featured On OncLive.com 3Medical Equipment Solutions Corp. Awarded $2 Million contract To Service DoD 2
... , Feb. 10 CORD:USE Cord Blood Bank ... System, the fifth-largest public healthcare system in the nation, to ... global registry for patients in need of a potentially life-saving ... will allow CORD:USE to continue building the National Cord Blood ...
... , , ... Cell-Teva Joint Venture,(JV) announced today that the Data Monitoring Committee (DMC) ... of StemEx (called ExCell) and has recommended that the JV,continue to ... take place during Q2 2010. StemEx is being evaluated as a,therapeutic ...
Cached Medicine Technology:CORD:USE Cord Blood Bank Announces Partnership with Memorial Healthcare System 2Data Monitoring Committee Recommends Continuation of Phase III Study of StemEx(R), a Cord Blood Stem Cell Product, for Leukemia and Lymphoma 2Data Monitoring Committee Recommends Continuation of Phase III Study of StemEx(R), a Cord Blood Stem Cell Product, for Leukemia and Lymphoma 3
(Date:7/30/2014)... is being financially exploited often by their own ... poor and black people. It merits the scrutiny of ... about the dignity and well-being of older Americans, says ... the US. She led one of the largest American ... appear in the Journal of General Internal Medicine ...
(Date:7/30/2014)... study of high school students by University of Adelaide ... between insomnia-related mental health conditions among teens. , ... more than 300 Australian high school students aged 12-18 ... and the time of day they were most active ... in the journal Sleep Medicine , ...
(Date:7/30/2014)... The shocking news of an Ohio teen who died ... dangers of the normally well-tolerated and mass-consumed substance. To ... consuming too much caffeine, scientists are reporting progress toward ... of the stimulant in most beverages and even breast ... Agricultural and Food Chemistry . , Mani Subramanian and ...
(Date:7/30/2014)... Texas (PRWEB) July 30, 2014 The ... (2013-18)” provides an insight into the market dynamics and ... report covers the actual and forecasted market sizing of ... various factors fuelling the demand of the same. It ... segment and major players in the market. Further, the ...
(Date:7/30/2014)... 30, 2014 4DSP’s new CES720 (Compact ... system designed to provide a complete and generic processing ... system is housed in an enclosure measuring five inches ... features a low-power x86 CPU tightly coupled to a ... (FMC – VITA 57.1). The Kintex-7 410T ...
Breaking Medicine News(10 mins):Health News:Older adults are at risk of financial abuse 2Health News:Teen insomnia is linked with depression and anxiety 2Health News:Global Pulse Oximetry Market 2018 Opportunities and Trends Now Available at MarketReportsOnline.com 2Health News:Global Pulse Oximetry Market 2018 Opportunities and Trends Now Available at MarketReportsOnline.com 3Health News:4DSP Introduces a Compact Platform for UAVs with Embedded Processing and Flexible IO 2Health News:4DSP Introduces a Compact Platform for UAVs with Embedded Processing and Flexible IO 3Health News:4DSP Introduces a Compact Platform for UAVs with Embedded Processing and Flexible IO 4
... Americans are increasingly orienting themselves to video games, highlights ... polling firm//. ,According to the poll conducted ... respondents admitted that they enjoyed video games. This approximates ... the sampling error as well. ,Most adults ...
... guru Baba Ramdev, yoga when practiced regularly can ward off ... He also added that yoga not only cure but also ... just one reason behind the increasing number of cancer cases. ... disease," said Ramdev, who was recently in Ratlam district to ...
... have said that India is planning to start an ... infected with HIV// and need anti-HIV therapy to extend ... Control Organisation and Indian paediatricians are starting to work ... for children and provide training to medical professionals in ...
... financial toll on the poultry sector, with losses estimated at ... of chicken have drastically plummeted. ,Sindh and Punjab have ... of around Rs 60 million. Nearly 200,000 chickens have been ... ,Following the outbreak, an effective monitoring system has been instituted ...
... Department of Justice has revealed that mental hospitals ... widespread problems, including inadequate diagnoses //and treatment, improper ... ,In addition violence among patients, repeated suicide attempts ... led to visible signs of irreversible side effects ...
... reduction in the teaching hours for medical subjects such ... a pathetic state where medical students are unable to ... up confusing one organ with another. In addition to ... reduction in the teaching hours for biochemistry, pathology, physiology ...
Cached Medicine News:Health News:India To Estimate The Number Of Children Infected With HIV/AIDS 2Health News:Mental Hospitals Offer More Problems than Solutions 2Health News:Australian Medical Students Lack Anatomy Knowledge 2
This versatile convex array abdominal transducer is multi-frequency, offering 5 levels of fundamental frequencies in addition to 4 settings of Harmonic frequencies. This transducer provides superb im...
HST, versatile convex array abdominal transducer is multi-frequency, offering 5 levels of fundamental frequencies in addition to 4 settings of Harmonic frequencies. This transducer provides superb im...
... is ALOKAs answer to the ... Super High Density, versatile convex ... offering 5 levels of fundamental ... settings of Harmonic frequencies. This ...
The versatility of multiple imaging frequencies and a smaller transducer face make this transducer is perfect for intercostal imaging....
Medicine Products: