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British Journal of Cancer Reports Preclinical Evidence of Positive,Effect of Rice Bran on Intestinal Cancer

Study Shows 51% Reduction in Intestinal Adenomas Suggesting Possible Beneficial Mediation in the Prevention of Intestinal Cancer

EL DORADO HILLS, Calif., March 07, 2007 /PRNewswire/ -- NutraCea announced today the results of a study on the effect of rice bran on the number of intestinal adenomas in cancerous mice, published in the January 9, 2007 online edition of the prestigious British Journal of Cancer conducted at the Department of Cancer Studies and Molecular Medicine, at the University of Leicester, Leicester, UK, has produced some encouraging results on the dietary benefits of rice bran. The results of the controlled study demonstrated that by consuming a suitable daily dose of stabilized rice bran, an average 51% reduction in the number of precancerous adenomas in the stomach and large intestine of mice was observed.

"The results show that the mice that received stabilized rice bran (30%) into their diets had a significant decrease in the number of intestinal adenomas compared to mice on the control diet. Rice bran also decreased intestinal hemorrhage in this group," said Margie Adelman, Senior Vice President of NutraCea. "When rice bran in the mice diet was reduced from 30% to 10%, adenoma development was not significantly retarded compared to those in the control model. This suggests that adenoma-retarding activity of rice bran is dose-related, possibly linked predominately to the fiber content of the bran."

Prof. Andreas Gescher of the University of Leicester in the UK, the principal investigator, says: "We compared the cancer-preventive efficacy of NutraCea Stabilized Rice Bran in mouse models of prostate, breast and intestinal cancers. These mice ate a diet containing 30% rice bran. Whilst there was no effect of rice bran on the development of prostate or breast cancer, rice bran significantly retarded the development of adenomas in so-called "Min mice," a mouse strain which is prone
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