Navigation Links
Breast Cancer and HER-2/neu: Diagnostic Tools for Targeted Therapy


Michael S. Singer, M.D., Ph.D.
Harvard Medical School
Contributing Editor

With over 200,000 new cases and 40,000 deaths per year, breast cancer undoubtedly qualifies as one of Americas most serious health problems. Recently, efforts to develop early detection methods and more effective therapy have made important progress. This is particularly true at the molecular level, where discoveries on protein expression have translated into new diagnostic tests and targeted therapies. An example is the finding that tumors expressing estrogen receptors (so called ER+ tumors) tend to respond to tamoxifen, a selective estrogen receptor modulator. Conversely, ER tumors tend to respond better to chemotherapy and not to tamoxifen. Another revolutionary example is that of Her-2/neu protein (also called c-erbB2), which is overexpressed in approximately 2530% of breast cancers. With herceptin (trastuzumab) and other preferential medications available to treat these patients, the need has emerged for routine laboratory methods to detect Her-2/neu overexpression. A wide array of tools has arrived to fulfill this purpose.

Human cells normally carry and express two copies of Her-2/neu, which is located on chromosome 17 and encodes a cell-surface receptor for epidermal growth factor. Like many growth factor receptors, Her-2/neu functions as a tyrosine kinase and moves cells forward on the cell cycle, which involves DNA replication and cell division. Her-2/neu therefore falls into the class of proto-oncogenes. A key discovery is that some 2530% of breast cancers carry amplifications (multiple copies) of the Her-2/neu gene, which lead to overexpression of Her-2/neu protein. The over-abundance of Her-2/neu receptor accelerates the cell cycle and causes cells to divide more rapidly and haphazardly. This explain why Her-2/neu overexpression is associated with more rapid tumor growth and a worse prognosis.

Th
'"/>




Page: 1 2 3

Related medicine technology :

1. New Advances in Gastric Diagnostics: Smaller is Better
2. West Nile Virus Screening and Diagnostics Technology Emerges In Step with North American Outbreak
3. Non-Invasive Diagnostic Tests for Celiac Disease
4. Bench-Top Centrifuges--Basic Tools for the Small Lab
5. Appendicitis: Evolving Tools to Diagnose a Classic Disease
6. Gene Chips to Detect CYP Variations: A New Step Toward Customized Medical Therapy.
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Breast Cancer and HER neu Diagnostic Tools for Targeted Therapy
(Date:5/29/2015)... PARAMUS, N.J. , May 29, 2015 A ... Business," is being presented at the Cannabis World ... in New York, NY .  Taking place ... of a dedicated day of education at the leading event ... industry. Led by Clover Leaf University, the ...
(Date:5/29/2015)... -- Dr. Yair Walzer has added a leading edge ... caused by menopause. The MonaLisa Touch™, an in-office procedure that ... in 2014. Dr. Walzer is one of the first physicians ... fractional CO 2 laser specifically designed to help postmenopausal ... In 2010 there were greater than 46M women between the ...
(Date:5/29/2015)... CANOGA PARK, Calif. , May 29, 2015 /PRNewswire/ ... practices with 1-5 physicians ranks Praxis EMR as #1 ... -based Black Book Market Research LLC conducts a poll ... Satisfaction Survey with the results.    ... satisfaction rating of the 18 performance based criteria used ...
Breaking Medicine Technology:Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 2Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 3Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 4The Newest FDA-Cleared Breakthrough In Women's Health Treatments 2Praxis EMR Ranks #1 for Physician Satisfaction in Black Book's 2015 Survey of Solo and Small Practices 2
... 2011 Giant Eagle®, the region,s leading food and ... prestigious Chairman,s Citation Award. Giant Eagle is ... the outstanding accomplishments of individuals, corporations, institutions and organizations ... had a positive impact in advancing the mission of ...
... MINNEAPOLIS, March 17, 2011 QuickCheck Health, an innovative ... it will be presenting at the 2011 World Health ... National Resort and Conference Center in Washington D.C. ... previous presentations have been well received. "Even with reform, ...
Cached Medicine Technology:Giant Eagle® Receives American Diabetes Association Chairman's Citation Award 2Giant Eagle® Receives American Diabetes Association Chairman's Citation Award 3QuickCheck Health Inc. CEO to Present at World Health Care Congress Conference April 4-6 in Washington D.C. 2
(Date:5/29/2015)... FL (PRWEB) May 29, 2015 According to ... one in 10 full-time workers has a substance abuse problem ... from more than 111,500 adults with full-time jobs, revealed that ... in the previous year. (1) The National Council on Alcoholism ... billion per year, and an estimated 70% of the 14.8 ...
(Date:5/29/2015)... 2015 To compile the list, the ... that have several awards for clinical and general excellence. ... stood out to them in terms of overall excellence, ... , The 50 Great Health Systems to Know 2015 ... (Altamonte Springs, Fla.) , Advocate Health Care (Downers Grove, ...
(Date:5/29/2015)... (PRWEB) May 29, 2015 World Patent ... products, announces that it has signed a 10 year ... patent that aims to let people learn about any ... real time. , "This is an exciting day for ... said Scott J. Cooper, CEO and Creative Director of ...
(Date:5/29/2015)... Mediaplanet has joined forces with Raw Elements ... importance of proper sun protection. The print component of ... circulation of approximately 250,000 copies and an estimated readership ... through a vast social media strategy, and across a ... explore the digital version of the campaign, click ...
(Date:5/29/2015)... BC (PRWEB) May 29, 2015 Shaila ... & Sports Rehab, has recently stated in a new ... and suffer”. Urinary Continence is commonly seen as a ... before seeking help. Expert physiotherapists like Shaila Jiwa try ... the condition. , Incontinence is a condition that ...
Breaking Medicine News(10 mins):Health News:Novus Medical Detox Comments on Government Study Findings: One in 10 American Workers Struggling with Substance Abuse 2Health News:Novus Medical Detox Comments on Government Study Findings: One in 10 American Workers Struggling with Substance Abuse 3Health News:Novus Medical Detox Comments on Government Study Findings: One in 10 American Workers Struggling with Substance Abuse 4Health News:Becker's Hospital Review Names 50 Great Health Systems to Know 2Health News:Becker's Hospital Review Names 50 Great Health Systems to Know 3Health News:Licensing Alert! World Patent Marketing's Latest Blockbuster Licensing Deal Gets A New Twist on Technology With The Live Expert Chat Room 2Health News:Licensing Alert! World Patent Marketing's Latest Blockbuster Licensing Deal Gets A New Twist on Technology With The Live Expert Chat Room 3Health News:Licensing Alert! World Patent Marketing's Latest Blockbuster Licensing Deal Gets A New Twist on Technology With The Live Expert Chat Room 4Health News:Licensing Alert! World Patent Marketing's Latest Blockbuster Licensing Deal Gets A New Twist on Technology With The Live Expert Chat Room 5Health News:Patients of Urinary Incontinence Should Not "Hide And Suffer," States Physiotherapist from Burnaby Physiotherapy Clinic 2
... have allegedly found inconsistencies in President Bush's AIDS-fighting program//, ... difficult, to gauge the success of the programme. ... AIDS program, valued at $15-billion has not enabled a ... has assisted. The Bush administration is now trying to ...
... of dioxin in a U.S. beef consignment to Seoul, according ... and the American beef industry are still unconvinced about the ... which is higher than Korea’s 5-picogram level. ,USDA ... we found 6.26 picograms of dioxin [in our samples], public ...
... Congress, held in Boston earlier this year,// a trio ... were awarded the world transplant community's highest honor: The ... mark outstanding new research that will lead to tomorrow's ... is a special issue dedicated to the World Transplant ...
... resulting from excessive binge-alcohol drinking can be prevented ... (ibandronate), a Loyola University Health System study shows. ... which is detrimental to youngsters and young adults, ... osteoporotic post-menopausal women,” said principal study investigator Dr. ...
... and health facilities has revealed that 14 inmates have died// ... deaths are believed to have resulted from treatment errors and ... reported that the jail infrastructure lacks adequate doctors, nurses and ... medical conditions ranging from hernia to heart disease. ...
... times when most people just don’t move away from ... helps them to fulfill psychological needs. ,University of ... and enquired from 1000 gamers their motivation to keep ... Emotion this month suggest that people enjoy video games ...
Cached Medicine News:Health News:Highlights from World Transplant Congress 2Health News:Highlights from World Transplant Congress 3Health News:Vitamin D or Anti-osteoporosis Drug Reduces Bone Loss from Binge Drinking 2Health News:Why People are Addicted to Video Games? 2
The CGRL is a Wide Angle Contact Glass designed for laser photocoagulation and diagnosis of the retina....
For use with Slitlamps which have a smaller distance between the eye and the reduction prism than the Haag-Streit 900. Designed to work with argon/YAG Lasers....
... capture and management system that acquires extremely ... Angiography images. It interfaces with most current ... from any ophthalmic device with video, digital ... quality colour Retinal Images from non-mydriatic fundus ...
... that replaces the old technology, the automated ... bringing virtually unlimited charts to the patient ... at the practitioners finger tips. The STIMULi ... optotypes, associated vision tests and fixation devices ...
Medicine Products: