Navigation Links
Bionovo's MF101 Shows Positive Safety, Tolerability and Efficacy in,Phase 2 Trial

severity of hot flashes than the lower dose.

In secondary analyses, the percent of women reporting greater than 50% reduction in all hot flashes was statistically significantly higher in the MF101 high dose group compared to placebo (p=0.03) and in both doses of MF101 combined compared to placebo (p=0.05).

MF101 is a novel estrogen receptor beta agonist that is expected not to stimulate the endometrium or breast tissue. Safety analyses showed no cases of endometrial hyperplasia or uterine cancer during the trial and there were no differences in incidence of vaginal bleeding between the placebo group and the two cohorts treated with MF101. The only side effect that increased with MF101 treatment was loose stool/diarrhea (12% in each of the drug arms vs. 3% in placebo arm). Constipation was improved with MF101 therapy. These observations are consistent with the presence of soluble fiber in the drug extract, which future optimization of the manufacturing process will significantly reduce. Adherence to the study medication was high with 91% of the participants compliant with treatment after 12 weeks of therapy.

"I am very encouraged and pleased by the findings of this clinical trial," said Deborah Grady, M.D., Associate Dean for Clinical and Translational Science, Professor of Medicine and Director of the University of California, San Francisco (UCSF) Women's Health Clinical Research Center. "The combination of a trend to better efficacy with a higher dose of MF101 and a very strong safety profile of a drug that was very well tolerated by menopausal women is exciting news. These early positive clinical results are not only encouraging for discovering a safer therapy for hot flashes but also support the role of estrogen receptor beta as a novel target for treating menopausal symptoms."

"Recent clinical trials, such as the HERS and the WHI, elucidated important safety concerns of postmenopau
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
2. International ENDORSE Study Shows That the Majority of Hospitalized Patients Surveyed are at Risk for VTE and Many do not Receive Recommended VTE prophylaxis
3. New Study Shows That Extending Prophylaxis With Clexane / Lovenox (enoxaparin Sodium Injection) to 5 Weeks is More Effective Than 10 Days for Reducing the Risk of Venous Thromboembolism (VTE) in Acutely ill Medical Patients With Reduced Mobility
4. MediGene Announces Cancer-Fighting Virus Shows Promise in Early Clinical Trial
5. Study Shows Ixabepilone Demonstrated Clear Activity in Patients with Metastatic Breast Cancer Resistant to Anthracycline, Taxane, and Capecitabine
6. Ceragenix Compound Shows Promise for Treating Lethal Cystic Fibrosis Infections
7. Largest Cervical Cancer Vaccine Efficacy Trial Shows Cervarix Provides Excellent Protection Against Lesions Caused by Most Common Cancer-Causing Virus Types
8. CombinatoRx Product Candidate CRx-150 Shows Activity on DAS28 and Pain, but Not CRP
9. New Study Shows A1c Reduced Safely By Patients With Type 2 Diabetes Using Self-Adjusted Dosing Starting With Once-Daily Insulin Treatment Levemir
10. First Phase II Short-Term Study on Dapagliflozin Shows Results on Safety, Tolerability and Glycemic Markers in Subjects With Type 2 Diabetes
11. New Poll Shows Men, Women Incorrectly Blame Symptoms of Low Testosterone on Normal Aging
Post Your Comments:
(Date:4/17/2015)... Sigma-Aldrich Corporation (NASDAQ: ... Technology company, today announced the opening of its ... state-of-the-art Cell Culture Technical Center in Singapore.  Located ... customized support to meet customer needs, leveraging the ... new Technical Center will significantly enhance our ability ...
(Date:4/17/2015)... , April 17, 2015 TWi Pharmaceuticals, ... subsidiary, TWi Pharmaceuticals USA , has ... the United States.  It has been in close contact ... and expects to have its own label specialty generic ... in the U.S. pharma market. According to ...
(Date:4/16/2015)... , April 16, 2015 Mindray ... developer, manufacturer, and marketer of medical devices worldwide, ... Securities and Exchange Commission an Annual Report on Form ... year ended December 31, 2014. An electronic version of ... on Mindray,s investor relations website at  http://ir.mindray.com  or  ...
Breaking Medicine Technology:Sigma-Aldrich Expands Customer-Centric Model with Investments in Singapore That Localize World-Class Capabilities to Better Support Customers in Asia 2Sigma-Aldrich Expands Customer-Centric Model with Investments in Singapore That Localize World-Class Capabilities to Better Support Customers in Asia 3Sigma-Aldrich Expands Customer-Centric Model with Investments in Singapore That Localize World-Class Capabilities to Better Support Customers in Asia 4Sigma-Aldrich Expands Customer-Centric Model with Investments in Singapore That Localize World-Class Capabilities to Better Support Customers in Asia 5Mindray Files Annual Report on Form 20-F with the U.S. Securities and Exchange Commission 2
... 14, 2011 Reportlinker.com announces that a new ... Test-Volume-Sales-Forecasts-and-Supplier-Shares-by-Country.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=In_Vitro_Diagnostic title=,The 2011 Prostatic ... Test Volume, Sales ... Acid Phosphatase Testing Market: US, Europe, Japan ...
... Nov. 14, 2011 Reportlinker.com announces that a ... catalogue: Smart Infusion Pumps ... is one of the most common therapeutic procedures ... to receive. Yet the lack of standardization among ...
Cached Medicine Technology:The 2011 Prostatic Acid Phosphatase Testing Market: US, Europe, Japan 2The 2011 Prostatic Acid Phosphatase Testing Market: US, Europe, Japan 3The 2011 Prostatic Acid Phosphatase Testing Market: US, Europe, Japan 4The 2011 Prostatic Acid Phosphatase Testing Market: US, Europe, Japan 5Smart Infusion Pumps 2Smart Infusion Pumps 3
(Date:4/18/2015)... Carinsurancesavings.biz has released a new blog post ... during Spring. , Spring can be a great ... make sure they compare the newest policies before deciding ... more about Spring car insurance offers by reading the ... are becoming more and more popular. Many insurance brokerage ...
(Date:4/18/2015)... (PRWEB) April 18, 2015 Review of ... hosting a ‘Strategies for Success’ program for cataract surgeons ... meeting in San Diego, where eye surgeon Jeffrey L. ... this invitation-only event. Dr. Martin is the Managing Partner ... of Ophthalmology chose Dr. Martin to lead this year’s ...
(Date:4/18/2015)... Patients who undergo radiation for a ... in life, but the disease is likely to differ ... to radiation. Surviving Mesothelioma has just posted the details ... here to read it now. , Scientists from ... 45 patients who had both a hematologic cancer (like ...
(Date:4/18/2015)... NY (PRWEB) April 18, 2015 On April ... Security Threat Report , which they say, “exposes a tactical ... many new malware variants were introduced in 2014 - almost ... for Zero Day threats to be identified and patched by ... is abundantly clear that doing business in a digital world ...
(Date:4/18/2015)... Canada (PRWEB) April 18, 2015 French ... emotions on food choices when he uttered, “Tell me ... you are.” Using food to cope with stress or ... by Queendom.com indicates otherwise. Data collected from ... genders fall victim to emotional eating, but for different ...
Breaking Medicine News(10 mins):Health News:Auto Insurance Plans Are Cheaper During Spring! 2Health News:Dr. Jeffrey Martin Invited to Share Latest Breakthroughs in Cataract Care During Roundtable Discussion at National 2015 ASCRS Meeting In San Diego 2Health News:New Study Examines Relationship Between Radiation for Hematologic Cancers and Development of Mesothelioma, According to Surviving Mesothelioma 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 3Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 4Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 5Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 2Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 3Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 4Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 5Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 6
... regimen popular in 1980s doesn,t really lengthen life , , ... only a minimal effect on survival in breast cancer ... pretty clearly established that [high-dose chemotherapy] is a false ... Division of Quantitative Sciences at the University of Texas ...
... is a three-day multidisciplinary meeting that will serve as ... the prevention, screening and treatment of gastrointestinal cancers. More ... years Symposium which will feature nearly 600 scientific abstracts. ... 27, 2008, WHERE:, Orlando World Center Marriott , 8701 ...
... at the Universities of Nottingham and Leicester are collaborating ... image and quantify the air spaces inside the lungs ... to a link between childhood disease and later degenerative ... the world which have access to this particular magnetic ...
... Boston, MAMichael F. Holick, PhD, MD, was recently awarded ... Society of Endocrinology and Metabolism (CSEM). Holick, an ... received the award for decades of pioneering work that ... wide variety of chronic health conditions. , ...
... at Henry Ford Hospital on the use of a drug ... and aggressive type of brain cancer, has yielded results that ... II study focused on patients with glioblastoma multiforme (GBM), whose ... revealed that more than a third who were treated with ...
... them from being attacked by the female immune system could ... the human body, according to new research published on 14 ... in the Journal of Biological Chemistry, analysed these markers which ... sperm are not dangerous pathogens, and therefore should not be ...
Cached Medicine News:Health News:High-Dose Chemo Provides Little Benefit to Breast Cancer Patients 2Health News:High-Dose Chemo Provides Little Benefit to Breast Cancer Patients 3Health News:New technique reveals insights into lung disease 2Health News:Boston University Medical Center researcher honored 2Health News:Drug study for brain cancer shows promising results 2Health News:Sperm's immune-protection properties could provide link to how cancers spread 2
... facilitates stomal insertion., ,Adult TTS™ Adjustable ... trach tie, disconnect wedge, and obturator/introducer device., ... are intended for temporary use until the ... be obtained. Not for home care use. ...
... Lo-Profile™ tracheostomy tube is cosmetically pleasing ... styles of inner cannula come with ... cannula and a 15 mm ISO ... The semi-reusable inner cannula may be ...
... mm ISO termination for easy ventilator circuit ... place. , ,Clearly the softer choice ... , ,The Portex® flexible disposable inner ... polyvinyl chloride, providing a softer and more ...
... TRACH CARE Dual Lumen, allows ... the patient end of the ... Swivel Elbow and Direction Tip ... Offers multiple tracheostomy sizes, French ...
Medicine Products: