Navigation Links
Bionovo's MF101 Shows Positive Safety, Tolerability and Efficacy in,Phase 2 Trial

EMERYVILLE, Calif., June 04, 2007 /PRNewswire-FirstCall/ -- Bionovo, Inc.'s lead drug candidate, MF101, showed positive Phase 2 results for the treatment of hot flashes associated with menopause. Two hundred and seventeen women were enrolled in the company's double-blind, placebo- controlled, randomized Phase 2 trial. Postmenopausal women with 50 or more moderate to severe hot flashes per week were randomized to one of three treatment groups receiving MF101 (5 grams/day), MF101 (10 grams/day), or placebo for twelve weeks. The trial was led by Dr. Deborah Grady at the University of California, San Francisco and was conducted at six medical centers in the United States: University of California, San Francisco, University of Minnesota, Minneapolis, University of Pittsburgh, University of Tennessee, Memphis, University of Alabama, Birmingham and the San Diego Medical Center for Clinical Research.

Bionovo's primary objectives in the Phase 2 clinical trial were to assess the safety, tolerability and the potential efficacy of two doses of MF101 to reduce the frequency and severity of hot flashes. Both doses of MF101 were more effective than placebo at reducing the frequency and severity of hot flashes from the start of the trial until the end of the treatment period 12 weeks later. In a paired t-test, comparing the number of hot flashes per day after 12 weeks of treatment, MF101 5 gm was better than placebo at 12 weeks but did not reach statistical significance (p=0.06). The higher dose was statistically superior to placebo with a p value of 0.05 and both doses combined were superior to placebo with a p value of 0.04. MF101 showed a trend for improvement in severity of hot flashes compared to placebo with the higher dose showing greater improvement (p=0.1) than the lower dose (p=0.12) and with both doses combined superior to placebo (p=0.08). There was a dose response trend suggesting that the higher dose of MF101 was more effective at reducing both frequency and
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
2. International ENDORSE Study Shows That the Majority of Hospitalized Patients Surveyed are at Risk for VTE and Many do not Receive Recommended VTE prophylaxis
3. New Study Shows That Extending Prophylaxis With Clexane / Lovenox (enoxaparin Sodium Injection) to 5 Weeks is More Effective Than 10 Days for Reducing the Risk of Venous Thromboembolism (VTE) in Acutely ill Medical Patients With Reduced Mobility
4. MediGene Announces Cancer-Fighting Virus Shows Promise in Early Clinical Trial
5. Study Shows Ixabepilone Demonstrated Clear Activity in Patients with Metastatic Breast Cancer Resistant to Anthracycline, Taxane, and Capecitabine
6. Ceragenix Compound Shows Promise for Treating Lethal Cystic Fibrosis Infections
7. Largest Cervical Cancer Vaccine Efficacy Trial Shows Cervarix Provides Excellent Protection Against Lesions Caused by Most Common Cancer-Causing Virus Types
8. CombinatoRx Product Candidate CRx-150 Shows Activity on DAS28 and Pain, but Not CRP
9. New Study Shows A1c Reduced Safely By Patients With Type 2 Diabetes Using Self-Adjusted Dosing Starting With Once-Daily Insulin Treatment Levemir
10. First Phase II Short-Term Study on Dapagliflozin Shows Results on Safety, Tolerability and Glycemic Markers in Subjects With Type 2 Diabetes
11. New Poll Shows Men, Women Incorrectly Blame Symptoms of Low Testosterone on Normal Aging
Post Your Comments:
(Date:12/1/2008)...Dec. 1 Vical Incorporate... a $1.0 million milestone payment from Merck &...a Phase I clinical trial of an investigational pla...ine is based on Vical,s DNA gene delivery technolo...ase (hTERT). hTERT is the subject of separate lice...
(Date:11/28/2008)...Z, Germany, November 28 German bio...rship in specialized HIV monitoring and,AIDS pati...ing countries. In,the year 2008, 2.5 million pati...robust and highly affordable "CyFlow" system, supp...with HIV/AIDS. Due to introduction of the,Partec ...
(Date:11/26/2008)...Minn., Nov. 26 Children...t significantly increased risk of developing menta...s of a Mayo Clinic study published this month in ...Academy of Pediatrics. , , The retrospectiv...ts with strabismus (misaligned eyes) and compared ...
(Date:11/25/2008)...reness can improve recovery , , Audio and W...ilable on the Mayo Clinic News Blog. Please see th..., ROCHESTER, Minn., Nov. 25 /PRNewswire-USNewswi...oke patients don,t think they,re having a stroke -... their condition worsens. The findings appear in t...
Breaking Medicine Technology:Vical Receives Milestone Payment from Merck & Co., Inc. Triggered by Planned Initiation of Investigational Cancer DNA Vaccine Trial 2German Innovation for HIV/AIDS Diagnostics has Been Used 2.5 Million Times in 2008 2Eye Divergence in Children Triples Risk of Mental Illness 2Do You Know You're Having a Stroke? 2Do You Know You're Having a Stroke? 3IOS Press congratulates IPCC with Nobel Peace Prize 1518 1Group Seeks Refinement of Knee Arthritis Treatment Guidelines 7942 1Group Seeks Refinement of Knee Arthritis Treatment Guidelines 7942 2DelSite Nasal Powder Technology Could Reduce Recently Reported Waste in Federal Vaccine Program 2116 1DelSite Nasal Powder Technology Could Reduce Recently Reported Waste in Federal Vaccine Program 2116 2DelSite Nasal Powder Technology Could Reduce Recently Reported Waste in Federal Vaccine Program 2116 3Pharmos Corporation to Present at the 2007 RBC Capital Markets Healthcare Conference 2114 1Pharmos Corporation to Present at the 2007 RBC Capital Markets Healthcare Conference 2114 2
...2, 2007 - Ceragenix Pharmaceuticals,Inc. (OTCBB:C...tious disease and dermatology, today announced tha...onstrated virtually no biofilm,formation in a 21 d...eated with Ceragenins,were soaked daily in a phosp...heter. At day 21, the catheters were challenged wi...
..., 2007: Progen Industries Limited,(ASX: PGL; NASDA...se II liver cancer data has been accepted for late...ation for the Study of the Liver,(EASL). Progen wi...ncer trial at the American Association for Cancer ...ation of having final data fully analysed and read...
Other Medicine Technology:Ceragenix Announces Ceragenins Virtually Prevent Catheter Biofilm,Formation in 21 Day Study 2Ceragenix Announces Ceragenins Virtually Prevent Catheter Biofilm,Formation in 21 Day Study 3PI-88 Data to be Presented at Key International Conferences 2PI-88 Data to be Presented at Key International Conferences 3
(Date:12/2/2008)...Resilient, Cost and Energy Efficient Information I... EMC Corporation (NYSE: EMC ), th...ions, today announced that the Daughters of Charit...ospitals spanning the California coast, has consol...s continuity functions to deliver new online clini...
(Date:12/2/2008)...valuate Efficacy of Commercially Available Hypomet...Dec. 2 Eisai Corporation of North ...the first clinical trial evaluating the activity o...o Vidaza(R) (azacitidine) in adult patients with i...splastic syndromes (MDS), a potentially life-threa...
(Date:12/2/2008)...arotz Dental is now one of only two dental,practi...ew Attachment,Procedure). This is the only laser...approved for new attachment of gum and bone tissue...sue, without removing healthy tissue, maintains,t...in and discomfort to the,patient, closes the peri...
(Date:12/2/2008)...Call/ -- Global Med Technologies(R), Inc.,("Globa...), an international,e-Health, medical information...opean subsidiary, Inlog S.A., has licensed its Edg...rveur" in France, to 21 Assistance Publique -,Hop...3,000 patient beds. For,Global Med, this project ...
Breaking Medicine News(10 mins):Health News:Daughters of Charity Health System Improves IT Efficiency and Accelerates Time-to-Treatment with EMC 2Health News:Daughters of Charity Health System Improves IT Efficiency and Accelerates Time-to-Treatment with EMC 3Health News:Daughters of Charity Health System Improves IT Efficiency and Accelerates Time-to-Treatment with EMC 4Health News:Eisai Will Initiate First Head-to-Head Study Comparing Dacogen(R) (decitabine for injection) and Vidaza(R) (azacitidine) in Patients with Myelodysplastic Syndromes 2Health News:Eisai Will Initiate First Head-to-Head Study Comparing Dacogen(R) (decitabine for injection) and Vidaza(R) (azacitidine) in Patients with Myelodysplastic Syndromes 3Health News:Barotz Dental Now Offering Laser Gum Therapy 2Health News:Global Med Technologies(R)' European Subsidiary to Provide Strategic Blood Transfusion Software for 21 Paris Hospitals 2Health News:Global Med Technologies(R)' European Subsidiary to Provide Strategic Blood Transfusion Software for 21 Paris Hospitals 3Health News:Global Med Technologies(R)' European Subsidiary to Provide Strategic Blood Transfusion Software for 21 Paris Hospitals 4
...armaceuticals Inc (RPI) has received a tentative a...sinopril is recommended for hypertension, either a...anti-hypertenive agents. It is also used as adjunc...t failure and patients who do not respond to diure...
...s of drugs based on a widely used anticancer drug,...fects in the laboratory and in mice, according to ...eresting for the treatment of these tumors. // Pr...were extremely active in blocking the same cell ta...
...ro, Cipro. That's been the mantra of the media as ...ds who weren't -- clamor for the potent antibiotic...eaper and widely available medications can be used... penicillin. Although alternatives exist, Cipro is...
...ental anti-cancer drug has shown effectiveness in ...o a new report. Researchers say the drug probably ...seful for treating other types of cancer. Dr. Anto...esda, Maryland, and colleagues tested the drug, de...
Other Medicine News:
Portable - Battery Powered (6 size AA required). Fast, Lightweight Strain Gage Mechanism. Unit conversion (g, ct, oz, ozt, GN, dwt, mom, dwt, tael), Specific Gravity calculation, Piece Counting and P
Portable - Battery Powered (6 size AA required). Fast, Lightweight Strain Gage Mechanism. Unit conversion (g, ct, oz, ozt, GN, dwt, mom, dwt, tael), Specific Gravity calculation, Piece Counting and P
Small, comes in a compact carrying case, carrying pouch included.
60 month warranty, constructed entirely of aluminum alloy, allows the selection of 11 units of measure.
Medicine Products: