Navigation Links
Bionovo's MF101 Shows Positive Safety, Tolerability and Efficacy in,Phase 2 Trial

EMERYVILLE, Calif., June 04, 2007 /PRNewswire-FirstCall/ -- Bionovo, Inc.'s lead drug candidate, MF101, showed positive Phase 2 results for the treatment of hot flashes associated with menopause. Two hundred and seventeen women were enrolled in the company's double-blind, placebo- controlled, randomized Phase 2 trial. Postmenopausal women with 50 or more moderate to severe hot flashes per week were randomized to one of three treatment groups receiving MF101 (5 grams/day), MF101 (10 grams/day), or placebo for twelve weeks. The trial was led by Dr. Deborah Grady at the University of California, San Francisco and was conducted at six medical centers in the United States: University of California, San Francisco, University of Minnesota, Minneapolis, University of Pittsburgh, University of Tennessee, Memphis, University of Alabama, Birmingham and the San Diego Medical Center for Clinical Research.

Bionovo's primary objectives in the Phase 2 clinical trial were to assess the safety, tolerability and the potential efficacy of two doses of MF101 to reduce the frequency and severity of hot flashes. Both doses of MF101 were more effective than placebo at reducing the frequency and severity of hot flashes from the start of the trial until the end of the treatment period 12 weeks later. In a paired t-test, comparing the number of hot flashes per day after 12 weeks of treatment, MF101 5 gm was better than placebo at 12 weeks but did not reach statistical significance (p=0.06). The higher dose was statistically superior to placebo with a p value of 0.05 and both doses combined were superior to placebo with a p value of 0.04. MF101 showed a trend for improvement in severity of hot flashes compared to placebo with the higher dose showing greater improvement (p=0.1) than the lower dose (p=0.12) and with both doses combined superior to placebo (p=0.08). There was a dose response trend suggesting that the higher dose of MF101 was more effective at reducing both frequency and
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
2. International ENDORSE Study Shows That the Majority of Hospitalized Patients Surveyed are at Risk for VTE and Many do not Receive Recommended VTE prophylaxis
3. New Study Shows That Extending Prophylaxis With Clexane / Lovenox (enoxaparin Sodium Injection) to 5 Weeks is More Effective Than 10 Days for Reducing the Risk of Venous Thromboembolism (VTE) in Acutely ill Medical Patients With Reduced Mobility
4. MediGene Announces Cancer-Fighting Virus Shows Promise in Early Clinical Trial
5. Study Shows Ixabepilone Demonstrated Clear Activity in Patients with Metastatic Breast Cancer Resistant to Anthracycline, Taxane, and Capecitabine
6. Ceragenix Compound Shows Promise for Treating Lethal Cystic Fibrosis Infections
7. Largest Cervical Cancer Vaccine Efficacy Trial Shows Cervarix Provides Excellent Protection Against Lesions Caused by Most Common Cancer-Causing Virus Types
8. CombinatoRx Product Candidate CRx-150 Shows Activity on DAS28 and Pain, but Not CRP
9. New Study Shows A1c Reduced Safely By Patients With Type 2 Diabetes Using Self-Adjusted Dosing Starting With Once-Daily Insulin Treatment Levemir
10. First Phase II Short-Term Study on Dapagliflozin Shows Results on Safety, Tolerability and Glycemic Markers in Subjects With Type 2 Diabetes
11. New Poll Shows Men, Women Incorrectly Blame Symptoms of Low Testosterone on Normal Aging
Post Your Comments:
(Date:5/22/2013)... LAKE CITY , May 22, 2013 /PRNewswire/ ... ) today announced it received 510(k) clearance from ... Varian,s diagnostic X-ray image processing workstation that combines ... on one platform.  Varian,s Nexus DRF Digital X-Ray ... a variety of image receptors, including CCD cameras ...
(Date:5/22/2013)... Ambit Biosciences Corporation (Nasdaq: AMBI ... quizartinib (AC220), a potent and selective FLT3 inhibitor, will ... Society of Clinical Oncology, held May 31 through June ... . Information about the abstracts, ... can be viewed online at http://abstracts2.asco.org/ . Abstract ...
(Date:5/22/2013)... -- While many parents may think that allowing their ... under adult supervision keeps kids safe and leads to ... are serious negative consequences for both parents and teens. ... Treatment Research Institute (TRI) today announced the launch ... caregivers to help inform them about one of those ...
Breaking Medicine Technology:Varian Medical Systems Receives FDA 510(k) Clearance of its Nexus DRF Digital X-Ray Imaging System 2Ambit Biosciences Announces Presentations of Data from Clinical Investigations of Quizartinib at the Annual Meeting of the American Society of Clinical Oncology 2Ambit Biosciences Announces Presentations of Data from Clinical Investigations of Quizartinib at the Annual Meeting of the American Society of Clinical Oncology 3Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 2Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 3Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 4Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 5Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 6Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 7
... 14, 2011 Awarepoint Corporation,s CTO and SVP of Engineering, ... on trends driving location-based services (LBS), a market projected to ... Diego , the "Challenges and Opportunities of Indoor Location" ... 5:30 p.m. – 7:30 p.m. PDT in San Diego.  Panel ...
... April 14, 2011 Reportlinker.com announces that a ... catalogue: ENT Devices Market Outlook ... Devices and Implants and Diagnostic Devices ... Devices Market Outlook in United States to 2017 ...
Cached Medicine Technology:Awarepoint CTO, Matt Perkins, to Serve as Panelist at CommNexus San Diego Event 2Reportlinker Adds ENT Devices Market Outlook in United States to 2017 - Hearing Aid Devices and Implants and Diagnostic Devices 2Reportlinker Adds ENT Devices Market Outlook in United States to 2017 - Hearing Aid Devices and Implants and Diagnostic Devices 3Reportlinker Adds ENT Devices Market Outlook in United States to 2017 - Hearing Aid Devices and Implants and Diagnostic Devices 4Reportlinker Adds ENT Devices Market Outlook in United States to 2017 - Hearing Aid Devices and Implants and Diagnostic Devices 5Reportlinker Adds ENT Devices Market Outlook in United States to 2017 - Hearing Aid Devices and Implants and Diagnostic Devices 6Reportlinker Adds ENT Devices Market Outlook in United States to 2017 - Hearing Aid Devices and Implants and Diagnostic Devices 7Reportlinker Adds ENT Devices Market Outlook in United States to 2017 - Hearing Aid Devices and Implants and Diagnostic Devices 8Reportlinker Adds ENT Devices Market Outlook in United States to 2017 - Hearing Aid Devices and Implants and Diagnostic Devices 9Reportlinker Adds ENT Devices Market Outlook in United States to 2017 - Hearing Aid Devices and Implants and Diagnostic Devices 10Reportlinker Adds ENT Devices Market Outlook in United States to 2017 - Hearing Aid Devices and Implants and Diagnostic Devices 11Reportlinker Adds ENT Devices Market Outlook in United States to 2017 - Hearing Aid Devices and Implants and Diagnostic Devices 12
(Date:5/21/2013)... 22, 2013 Spring is the perfect ... farmers' markets filled with whole foods to weather perfect ... of the season the nutrition experts at Brilliant Nutrition ... to miss. , 1. Eating Locally, With the abundance ... to linger and explore, spring is a great time ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 Heritage Woods ... a BMA affordable assisted living community, is hosting a Quality ... Arthritis at 2 p.m. on Tuesday, May 28. , The ... Illinois, serves older adults of all incomes, including those on ... The Arthritis program is open to the public. There ...
(Date:5/21/2013)... MI (PRWEB) May 21, 2013 Standard ... showroom test-drive and little else. However given industry’s less ... available to shoppers via the internet, Consumer Mattress Reports ... guide, “ Choosing The Best Mattress .” , This ... insider tips and suggestions that may not be readily ...
(Date:5/21/2013)... Daily Gossip Magazine published well-documented articles that are ... people informed on the latest weight loss methods by publishing ... in-depth review of Kyle Leon’s Customized Fat ... want to lose weight or stay in shape with the ... was created by a popular fitness trainer, Kyle Leon, who ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 Patients of Dr. ... who have lost teeth due to gum disease and would ... for gum disease treatment with laser gum surgery. ... have the highest success rate out of all tooth replacement ... is a relatively new procedure cleared by the Food and ...
Breaking Medicine News(10 mins):Health News:Brilliant Nutrition Offers 5 Ways to Live Healthier and Inspired this Spring 2Health News:Brilliant Nutrition Offers 5 Ways to Live Healthier and Inspired this Spring 3Health News:Heritage Woods of Dwight Affordable Assisted Living to Host Informational Program on the Do's and Don'ts of Arthritis 2Health News:Choosing the Best Mattress Simplified in Consumer Mattress Reports’ Latest Article 2Health News:Customized Fat Loss Plan Review and Diet Secrets Revealed By Daily Gossip Magazine 2Health News:Shenk Dental Care Stimulates Bone Growth for Gum Disease Patients Seeking Dental Implants with Laser Gum Surgery in Atlanta, GA 2
... Calif., March 20 Nordic Naturals was,recently ... 2008 ConsumerLab.com,Survey of Vitamin and Supplement Users. ... Consumer Satisfaction and #1 Rated Health Food,Store ... the highest,customer satisfaction ratings of all brands ...
... Year, BREA, Calif., March 20 In the ... disaster. Veterinary Pet Insurance (VPI),the nation,s oldest and largest ... data to determine the most commonly ingested,household toxins and ... claims received in 2007 for each type. Shockingly, the ...
... when you are,out in the community serving the elderly ... not being met?, That is the question that ... ask, and the M.J. Murdock Charitable Trust has helped,to ... (CPI), a,three-year program that both CDM and the Murdock ...
... executive chairman of Aon Corporation, today announced he intends ... the world,s largest,insurance and reinsurance intermediary, and a global ... to a new management team under the,sound leadership of ... growth and success. After 41 years as CEO and ...
... partners face difficult decisions regarding treatment, and accurate information ... to results of a multi-center study published Wednesday in ... after prostate surgery, external radiation or brachytherapy (radioactive seeds) ... but also on factors that have been previously overlooked, ...
... day last spring, fossil hunter and anatomy professor Kenneth Rose, ... part of a seminar at the Johns Hopkins University School ... looked oddly familiar. , That unanticipated eureka moment has led ... known record of rabbits. The fossil evidence in hand, found ...
Cached Medicine News:Health News:Nordic Naturals Named Top-Rated Supplement Brand in ConsumerLab.com Survey of Vitamin and Supplement Users! 2Health News:Veterinary Pet Insurance Data Reveals Well-Intended Pet Owners Unknowingly Poisoning Their Pets 2Health News:Veterinary Pet Insurance Data Reveals Well-Intended Pet Owners Unknowingly Poisoning Their Pets 3Health News:Veterinary Pet Insurance Data Reveals Well-Intended Pet Owners Unknowingly Poisoning Their Pets 4Health News:Local Non Profit Provides Solutions for Elderly and Disabled 2Health News:Local Non Profit Provides Solutions for Elderly and Disabled 3Health News:Patrick G. Ryan Announces Intention to Retire from Aon 2Health News:Patrick G. Ryan Announces Intention to Retire from Aon 3Health News:Prostate size and other neglected factors influence prostate cancer treatment satisfaction 2Health News:Prostate size and other neglected factors influence prostate cancer treatment satisfaction 3Health News:Good luck indeed: 53 million-year-old rabbit's foot bones found 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: