Navigation Links
Bionovo's MF101 Shows Positive Safety, Tolerability and Efficacy in,Phase 2 Trial

EMERYVILLE, Calif., June 04, 2007 /PRNewswire-FirstCall/ -- Bionovo, Inc.'s lead drug candidate, MF101, showed positive Phase 2 results for the treatment of hot flashes associated with menopause. Two hundred and seventeen women were enrolled in the company's double-blind, placebo- controlled, randomized Phase 2 trial. Postmenopausal women with 50 or more moderate to severe hot flashes per week were randomized to one of three treatment groups receiving MF101 (5 grams/day), MF101 (10 grams/day), or placebo for twelve weeks. The trial was led by Dr. Deborah Grady at the University of California, San Francisco and was conducted at six medical centers in the United States: University of California, San Francisco, University of Minnesota, Minneapolis, University of Pittsburgh, University of Tennessee, Memphis, University of Alabama, Birmingham and the San Diego Medical Center for Clinical Research.

Bionovo's primary objectives in the Phase 2 clinical trial were to assess the safety, tolerability and the potential efficacy of two doses of MF101 to reduce the frequency and severity of hot flashes. Both doses of MF101 were more effective than placebo at reducing the frequency and severity of hot flashes from the start of the trial until the end of the treatment period 12 weeks later. In a paired t-test, comparing the number of hot flashes per day after 12 weeks of treatment, MF101 5 gm was better than placebo at 12 weeks but did not reach statistical significance (p=0.06). The higher dose was statistically superior to placebo with a p value of 0.05 and both doses combined were superior to placebo with a p value of 0.04. MF101 showed a trend for improvement in severity of hot flashes compared to placebo with the higher dose showing greater improvement (p=0.1) than the lower dose (p=0.12) and with both doses combined superior to placebo (p=0.08). There was a dose response trend suggesting that the higher dose of MF101 was more effective at reducing both frequency and
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
2. International ENDORSE Study Shows That the Majority of Hospitalized Patients Surveyed are at Risk for VTE and Many do not Receive Recommended VTE prophylaxis
3. New Study Shows That Extending Prophylaxis With Clexane / Lovenox (enoxaparin Sodium Injection) to 5 Weeks is More Effective Than 10 Days for Reducing the Risk of Venous Thromboembolism (VTE) in Acutely ill Medical Patients With Reduced Mobility
4. MediGene Announces Cancer-Fighting Virus Shows Promise in Early Clinical Trial
5. Study Shows Ixabepilone Demonstrated Clear Activity in Patients with Metastatic Breast Cancer Resistant to Anthracycline, Taxane, and Capecitabine
6. Ceragenix Compound Shows Promise for Treating Lethal Cystic Fibrosis Infections
7. Largest Cervical Cancer Vaccine Efficacy Trial Shows Cervarix Provides Excellent Protection Against Lesions Caused by Most Common Cancer-Causing Virus Types
8. CombinatoRx Product Candidate CRx-150 Shows Activity on DAS28 and Pain, but Not CRP
9. New Study Shows A1c Reduced Safely By Patients With Type 2 Diabetes Using Self-Adjusted Dosing Starting With Once-Daily Insulin Treatment Levemir
10. First Phase II Short-Term Study on Dapagliflozin Shows Results on Safety, Tolerability and Glycemic Markers in Subjects With Type 2 Diabetes
11. New Poll Shows Men, Women Incorrectly Blame Symptoms of Low Testosterone on Normal Aging
Post Your Comments:
(Date:7/30/2014)... , July 30, 2014 The Board ... Pharmacy (AMCP) last evening expressed support for the ... Joint Commission of Pharmacy Practitioners (JCPP).  As a ... over a two-year period to develop a scalable, ... "Pharmacists are fast becoming one ...
(Date:7/30/2014)... July 30, 2014  Today the US Surgeon General issued ... sun tanning or sun burns stating they can lead directly ... Boris Lushniak , says that "skin cancer is a ... too much exposure to indoor and outdoor ultraviolet light is ... Aesthetic Medicine, in Boca Raton, Florida , ...
(Date:7/30/2014)... -- Research and Markets has announced the ... Industry Report 2014" report to their offering. ... Global and Chinese Aseptic Packaging Industry Report is a ... the global Aseptic Packaging industry with a focus on ... overview of the industry including definitions, classifications, applications and ...
Breaking Medicine Technology:AMCP Endorses JCPP "Pharmacists' Patient Care Process" 2Indoor and Outdoor Sun Tanning or Sun Burns Directly Linked to Deadly Melanoma Skin Cancer 2Global and Chinese Aseptic Packaging Industry Report 2014 2
... According to Millennium Research Group (MRG), the global ... light-emitting diode (LED) surgical lights will represent 100% of ... lights with significantly longer lasting LED lights. MRG,s ... report finds that adoption will be ...
... Ind. and FRANKLIN, Mass., Oct. 8 Chris Jensen ... has received the Safe Lifting Award presented by the ... pro bono health care injury prevention website. The award ... in safe patient handling, safe lifting and caregiver injury ...
Cached Medicine Technology:LEDs To Completely Replace Halogen Lights in the European Surgical Market By 2014 2LEDs To Completely Replace Halogen Lights in the European Surgical Market By 2014 3Chris Jensen Medical Center Saves Estimated $600,000 in First Year of Safe Patient Handling 2Chris Jensen Medical Center Saves Estimated $600,000 in First Year of Safe Patient Handling 3
(Date:7/31/2014)... Healthpointe Medical Group, one of ... the highest standards in health and safety for ... offering Occupational Medicine Services at their ... They also accept workers’ compensation cases and referrals ... services include, but are not limited to, return-to-work ...
(Date:7/31/2014)... Healthinsurancefacts.org has released a new blog post explaining how ... , In order to find affordable individual health ... can do this by visiting an insurance brokerage website ... should do proper research when looking for health insurance. ... of them can be advantageous in the appropriate context. ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 Dallas Fit ... Street, Dallas, Texas to 3821 Ross Avenue, also in Dallas, ... current and potential members to burn fat and get in ... this move because he believes that the new space will ... and fitness results they want as well as accommodate new ...
(Date:7/31/2014)... New York, NY (PRWEB) July 31, 2014 ... will host its first-ever event in New York on ... Eventi Hotel in Manhattan. , Featuring keynotes by ... Assemblyman Steve Katz (R-Yorktown), the event will include lunch ... Compassionate Care Act and the work NCIA is doing ...
(Date:7/31/2014)... CA (PRWEB) July 31, 2014 With a busy ... to not only live a healthy lifestyle but to ensure their ... can easily improve their mental health. “Eating right is key to ... of their day and have a completely healthy lifestyle,” expressed Chef ... or visit the blog here . , ", 1. Stop ...
Breaking Medicine News(10 mins):Health News:Occupational Medicine Services Available at Healthpointe’s Perris Facility 2Health News:Comparing Health Insurance Quotes Can Help Clients Find Affordable Plans 2Health News:Dallas Fit Body Boot Camp Moves to New Location, Announces Grand Opening Set for Saturday August 9th 2Health News:THURSDAY, AUG 7: First-Ever National Cannabis Industry Association Event in New York Will Feature Senator Savino, Assemblyman Katz, & Industry Leaders 2Health News:World Garden’s Cafe Launches ‘16 Simple Ways to Feel Connected to the World’ 2Health News:World Garden’s Cafe Launches ‘16 Simple Ways to Feel Connected to the World’ 3Health News:World Garden’s Cafe Launches ‘16 Simple Ways to Feel Connected to the World’ 4
... Synovics,Pharmaceuticals, Inc. (OTC Bulletin Board: SYVC), a ... Gange, has been,appointed Principal Executive Officer of ... responsibility of overseeing all executive functions. Mr. ... of directors and is the Chief,Financial Officer ...
... Nationwide,Health Properties, Inc. (NYSE: NHP ) today ... President, Tax. Mr. Laty had previously been the,Vice President, ... had,over eight years experience with a "Big 4" accounting ... Estate Investment Trusts. Mr. Laty is,a graduate of California ...
... do find 11 anti-seizure drugs heighten suicide risk, and ... 10 (HealthDay News) -- Anti-seizure drugs can cause ... warrant the government,s strongest warning label on them, a ... 20-member panel voted unanimously, with one abstention, to back ...
... of Mental Health estimates that in any given year, ... from some form of anxiety disorder, including debilitating conditions ... (PTSD). It is estimated that nearly 15 percent ... PTSD, underscoring the urgency to develop better treatment strategies ...
... trials, design may also mask risk of HIV drug resistance ... study questions whether vaginal microbicides being developed to help protect ... from the virus that causes AIDS. , The study, ... of the National Academy of Sciences , also shows that, ...
... anti-seizure drugs that showed double the risk , , THURSDAY, ... cause increased suicidal tendencies in patients, a U.S. health ... experts voted unanimously to back the findings on 11 ... Administration, the Associated Press reported. , In ...
Cached Medicine News:Health News:Synovics Pharmaceuticals Announces the Appointment of Jyotindra Gange as Principal Executive Officer 2Health News:Synovics Pharmaceuticals Announces the Appointment of Jyotindra Gange as Principal Executive Officer 3Health News:Synovics Pharmaceuticals Announces the Appointment of Jyotindra Gange as Principal Executive Officer 4Health News:Synovics Pharmaceuticals Announces the Appointment of Jyotindra Gange as Principal Executive Officer 5Health News:FDA Advisers Don't Back Epilepsy Drug Warnings 2Health News:Rutgers research identifies brain cells related to fear 2Health News:Rutgers research identifies brain cells related to fear 3Health News:Vaginal Microbicides Might Help More Men Than Women 2Health News:Epilepsy Drugs Can Cause Suicidal Tendencies, FDA Panel Finds 2Health News:Epilepsy Drugs Can Cause Suicidal Tendencies, FDA Panel Finds 3
Printed with large 20/200 E on one side and a series of five 20/20 tumbling Es on the other- calibrated to a 20 ft. distance. May be used to test and train peripheral awareness....
... 2/25 is an economically priced 2-channel ... and research use in the fields ... neurophysiology, biology, zoology, biochemistry and biomedical ... ADInstruments signal conditioners and transducers. Two ...
... The PowerLab/4SP is a high-performance data ... of research applications including human and animal ... biomedical engineering. The unit is capable of ... speeds (up to 200 000 samples per ...
... Worth 4 Dot with 955R Red/Green ... the presence of binocular vision. Consists ... illuminated discs: two green, one red ... at any distance. Patient wears red/green ...
Medicine Products: