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BioLineRx Presents Data From Successful Phase I Trial for BL-1020,in Schizophrenia at American Psychiatric Association Conference

SAN DIEGO--(BUSINESS WIRE)--May 22, 2007 - BioLineRx Ltd. (TASE:BLRX), Israel's leading drug development company, reported today data from its Phase I trial of BL-1020, the first GABA enhanced antipsychotic clinical candidate for the treatment of schizophrenia. The trial demonstrated that the compound was well tolerated and demonstrated biochemical evidence of dopamine blockade which is indicative of efficacy. BioLineRx presented the data in a poster (Abstract 235 XX) at the 2007 American Psychiatric Association (APA) Annual Meeting, which is being held May 19-24 in San-Diego, CA. A Phase II clinical trial for BL-1020 to determine the maximum tolerated dose in schizophrenic patients is expected to begin in the end of June, 2007.

"We are pleased to be presenting these promising results for BL-1020 at the APA Annual Meeting and look forward to the imminent initiation of the Phase II trial for this compound," commented Morris C. Laster, M.D., chief executive officer of BioLineRx.

The results of this trial were as follows:

1. BL-1020 demonstrated dopamine blockade by dose dependant elevation in serum prolactin levels which serves as a surrogate marker for dopamine antagonism. Dopamine hyperactivity is implicated in schizophrenia, and is the mechanism of action for various antipsychotic drugs.

2. In this trial BL-1020 appeared to be protective against extrapyramidal symptoms, a severe side effect of many antipsychotic medications. BL-1020 was extremely well tolerated in that no ECG psychiatric or neurological abnormalities were seen at any of the doses tested.

About the BL-1020 Phase I Clinical Trial

The Phase 1 trial of BL-1020 was a randomized, double blind, placebo-controlled, dose-escalation, single center study in healthy adult males (ages 21-45). The primary objective was to evaluate the safety and tolerability of escalating doses of BL-1020. The secondary objectives were to
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