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Bentley Reports Positive Results with Nasulin Intranasal Insulin,Spray at the American Diabetes Association Meeting

demonstrating more rapid onset of action than Humalog. When Nasulin was administered to different nostrils in 12 healthy male subjects, no significant differences in absorption were noted, although there was a slight trend in favor of the mildly congested nostril. However, researchers concluded this difference is unlikely to be clinically important, and noted if nostrils are totally blocked, they should be cleared with gentle nose-blowing before administration.

Adverse events reported in the smoking/non-smoking and dominant nostril studies included a total of four episodes of hypoglycemia in subjects receiving the investigational drug. In addition, some volunteers experienced transient, mild nasal irritation and/or watery eyes, which resolved rapidly. These transient findings were not consistently present with each dose, and were generally resolved within 15-20 minutes.

"These trials show favorable results for Nasulin intranasal insulin spray as being equivalent in several key clinical measures when compared to the leading formulations of injectable insulin," said John Sedor, president of Bentley. "For more than two decades, the medical community has been searching for a less painful and easier method for treating diabetes than insulin injections. Nasulin presents a significant opportunity of achieving this goal for many patients and has the potential for significantly better patient compliance than a routine of insulin injections. Nasulin does not require constant refrigeration for use, and the delivery device is small enough to be carried discretely in a pocket or purse. In addition, Nasulin does not enter the lungs, avoiding possible long-term effects on lung function and holding the potential for use in diabetes patients with COPD and asthma. We are excited by the prospects for Nasulin, and Bentley is committed to finding collaboration partners to help conduct the additional clinical studies necessary to make this potentially important diabetes tre
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