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Baxter Presents Phase I Inhaled Insulin Study Results at,Respiratory Drug Delivery Conference

fect (GIR-AUC0-10h of 2,734 vs 2,482 mg/kg) were comparable. Pharmacokinetic results were in accordance with these findings: RHIIP was absorbed faster (time to reach 10 percent of total area under the insulin curves 44 vs 66 min., p<0.0001), and maximum insulin levels were reached earlier (86 vs 141 min., p=0.002). The bioavailability of RHIIP relative to SC was more than 12 percent.

"These encouraging results show the bioavailability of RHIIP compare favorably with that observed for many other inhaled insulin preparations, even though the standard type of inhaler used in this study was not optimized for delivery of insulin to the deep lung," said Dr. Tim Heise, Profil Institut fur Stoffwechselforschung GmbH in Neuss, Germany, and principal investigator for the study. "RHIIP may have the potential to achieve even higher bioavailability through further improvements in the insulin delivery technique, and this will be the subject of further studies."

"We are very excited to share these results that illustrate the strong potential of PROMAXX technology," said Peter J. Arduini, corporate vice president and president of Baxter's Medication Delivery business. "We look forward to working with partners to apply this technology broadly to the formulation of therapeutic proteins and peptides."

About PROMAXX

PROMAXX is a proprietary drug delivery technology that has been developed to solve difficult drug delivery problems. PROMAXX microsphere technology offers narrow control of microsphere size. PROMAXX microspheres can be manufactured to meet formulation requirements for proteins including therapeutic monoclonal antibodies, peptides, low molecular weight drugs and nucleic acids including siRNA.

About Baxter

Baxter Healthcare Corporation is the principal domestic operating subsidiary of Baxter International Inc. . Baxter International Inc., through its subsidiaries, assists healthcare professionals and their patients with the treatment
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