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Avexa Reports Positive Phase IIb Result

1, patients continue to receive either ATC or 3TC up to week 24, but can also change their other background HIV medicines. After week 24, all patients openly receive ATC unblinded to week 48. After week 48, patients may elect to enter an extension study (AVX-201E) in which they continue to receive ATC in addition to their other HIV medicines.

47 patients were analysed after 21 days of treatment. Approximately one third were female, and approximately half had the highest levels of drug resistance. The majority of the patients were recruited in Argentina, with patient ages ranging from 22 to 59.

Safety data

No ATC drug-related serious adverse events have been observed to date. No patients have been withdrawn from the trial because of side effects related to ATC treatment. In particular there has been no significant incidence of hyperlipasaemia (an indicator of pancreatitis) or elevated liver enzymes (suggestive of liver toxicity) related to ATC. These are two serious and undesired side-effects associated with some other NRTIs. These data demonstrate the good safety profile for ATC in the clinical setting.

Full scientific data from the Phase IIb trial will be presented at an upcoming international scientific conference.

Contact

Avexa Limited
Dr. Julian Chick, +61 (03) 9208 4300
Chief Executive Officer
or
Bourse Communications
Mr. Rod North, + 61 (03) 9510 8309


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