( eachdrug to 26 different target recept...)Avanir Pharmaceuticals Presents IEED Prevalence and Updated Zenvia,Long-Term Safety Data at AAN Annual Meeting,Health

each drug to 26 different target receptor binding sites in the brain. Of the 26 potential target sites screened, dextromethorphan bound to the fewest suggesting a lower risk for side effects than the other drugs tested. The authors concluded that treatment effects with dextromethorphan in Involuntary Emotional Expression Disorder (IEED) may be related to the selectivity and affinity of dextromethorphan at Sigma1 receptor sites concentrated in the brainstem and cerebellum.

All three studies were sponsored by the Company.

About Zenvia

Zenvia is a combination of two well-characterized compounds, the therapeutically active ingredient dextromethorphan, and the enzyme inhibitor quinidine, which serves to increase the bioavailability of dextromethorphan. The first-in-class drug candidate is believed to help regulate excitatory neurotransmission in two ways, through pre-synaptic inhibition of glutamate release via sigma-1 receptor agonist activity, and through postsynaptic glutamate response modulation via uncompetitive, low-affinity NMDA antagonist activity. Zenvia is currently in development for the treatment of Involuntary Emotional Expression Disorder (IEED) and diabetic peripheral neuropathic pain.

In October 2006, the Company received an approvable letter for the treatment of Zenvia in IEED. To address safety concerns raised in the FDA's approvable letter for Zenvia for the treatment of IEED, the company intends to initiate a confirmatory phase III study with a new lower quinidine dose formulation of Zenvia. In April 2007 Avanir completed the first of two planned phase III studies in diabetic peripheral neuropathic pain where all primary endpoints were successfully met. The Company is considering whether it would be necessary or advisable to study a similar lower dose of quinidine in the second phase III trial being planned for diabetic peripheral neuropathic pain.

About Avanir

Avanir Pharmaceuticals is focused on developing,
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