Navigation Links
Avalon Pharmaceuticals to Present at the American Association for,Cancer Research 2007 Annual Meeting

e monosphospate dehydrogenase (IMPDH), an enzyme that is critical for cells to be able to synthesize guanosine triphosphate (GTP), a molecule required for DNA synthesis and cellular signaling. IMPDH is over expressed in some cancer cells, especially in the case of hematological malignancies. In laboratory experiments, AVN944 has been shown to inhibit IMPDH activity in cells, and suppress pools of GTP. Anticancer activities of IMPDH inhibitors correlate with sustained depletion of GTP pools both in cellular models and in human subjects. AVN944 appears to have a selective effect on cancer cells in that deprivation of GTP in normal cells results in a temporary slowing of cell growth, while GTP deprivation in cancer cells induces cell death, or apoptosis. Results from preclinical studies of AVN944 indicate that AVN944 inhibited the proliferation of lymphoid and myeloid cells, the principal cells involved in the most common types of human leukemias. In a single-dose, dose- escalation phase I clinical trial of AVN944 conducted in the United Kingdom in healthy volunteers, AVN944: (1) was well tolerated at all tested doses with no notable side effects; (2) demonstrated good pharmacokinetic properties; and (3) had a significant inhibitory effect on IMPDH enzyme activity. Avalon filed an IND with the FDA in August 2005 and initiated U.S. phase I clinical trials in January 2006 for the treatment of hematological cancers.

Avalon Pharmaceuticals is a biopharmaceutical company using its proprietary technology, AvalonRx(R), to discover and develop cancer therapeutics. Avalon has a lead product in Phase I clinical development (AVN944 - IMPDH inhibitor), as well as preclinical programs to discover inhibitors for the beta-catenin and aurora pathways now in late stage lead candidate optimization. Avalon also has discovery programs on modulators of survivin function and a drug discovery program targeting the MYC oncoprotein, one of the most important and previously intractable c
'"/>




Page: 1 2 3 4

Related medicine technology :

1. Avalon Pharmaceuticals Announces Positive Interim Results For AVN944 Phase I Trial
2. Avalon Updates the AVN944 Phase I Hematologic Malignancies Trial
3. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
4. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
5. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
6. Auxilium Pharmaceuticals to Present at the 2007 CEUT Emerging Growth Opportunities Conference
7. Sunesis Pharmaceuticals to Present at the C. E. Unterberg, Towbin Emerging Growth Conference
8. EPIX Pharmaceuticals to Present at the C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
9. Pro-Pharmaceuticals Updates Progress of Clinical Trials & Davanat 505 (b)(2) Filings
10. Cosmo Pharmaceuticals Reports Positive Preliminary Phase II/III Data with Rifamycin MMX in Infectious Diarrhea
11. Portola Pharmaceuticals Announces Positive Phase II EXPERT Results and Additional Oral and Poster Presentations at the XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH)
Post Your Comments:
(Date:7/28/2015)... , July 28, 2015 Transparency ... report, titled " Cancer Diagnostics Market - Global ... 2020 " . According to this report, the global ... of 7.6% during the forecast period of 2014 to 2020. ... US$100,994.5 million and is expected to be worth US$168,649.3 million ...
(Date:7/28/2015)... Pa. , July 28, 2015 Mike ... keynote address at Good Neighbor Pharmacy,s 2015 ... to Aug. 1 in Las Vegas, Nev. ... CNN,s television-show, "Somebody,s Gotta Do It," and Discovery Channel,s, "Dirty ... to celebrate the nation,s  "unsung heroes" – people whose hard ...
(Date:7/28/2015)... N.Y. , July 28, 2015 VirtualScopics, ... clinical trial imaging solutions, today announced that it will ... 4:00 p.m. ET market close on Tuesday, August 11, ... executive officer, and Jim Groff , chief financial ... discuss the company,s financial results and provide a business ...
Breaking Medicine Technology:Cancer Diagnostics Market is Expected to Grow at CAGR of 7.6% From 2014 to 2020, to be Worth US$168,649.3 Million by 2020: Transparency Market Research 2Cancer Diagnostics Market is Expected to Grow at CAGR of 7.6% From 2014 to 2020, to be Worth US$168,649.3 Million by 2020: Transparency Market Research 3Cancer Diagnostics Market is Expected to Grow at CAGR of 7.6% From 2014 to 2020, to be Worth US$168,649.3 Million by 2020: Transparency Market Research 4Mike Rowe to Address Community Pharmacists at ThoughtSpot 2015 2VirtualScopics, Inc. Schedules Second Quarter 2015 Financial Results Press Release, Conference Call And Webcast 2VirtualScopics, Inc. Schedules Second Quarter 2015 Financial Results Press Release, Conference Call And Webcast 3
... Actavis Group, the international generic pharmaceuticals company, ... US Food & Drug Administration to market Losartan Potassium ... 25 mg, 50 mg and 100 mg strength.  Losartan ... Iceland. Losartan Potassium Tablets, USP had US ...
... 12 WPI Holdings d/b/a Woodbury Health Products ("Woodbury"), ... announced today that it has completed the acquisition of ... Wilmington, North Carolina and founded in 1993, WMS is ... focused on urological catheters and sterile kits.  With a ...
Cached Medicine Technology:Actavis Receives Approval of Losartan Potassium Tablets, USP in the U.S. 2WPI Holdings Acquires Wilmington Medical Supply Inc. 2
(Date:7/29/2015)... Carolina (PRWEB) , ... July 29, 2015 , ... One ... nails in an assisted nursing facility, but that’s exactly what was happening on the ... to the facility are 3- and 4-year-olds from Kids Only , a five-star ...
(Date:7/28/2015)... (PRWEB) , ... July 29, 2015 , ... ... Susan Bentley as a 2015-2016 inductee into its VIP Woman of ... healthcare. NAPW is the nation's leading networking organization exclusively for professional women, boasting ...
(Date:7/28/2015)... ... July 28, 2015 , ... ProFont is back with a whole ... With ProFont: Cursive users can generate a hand drawn feel all with a click ... Users can select from either the upper and lowercase alphabet, special characters, numbers, and ...
(Date:7/28/2015)... MA (PRWEB) , ... July 28, 2015 , ... ... look, user-friendly navigation, portal to access industry practices, consumer education, resource library, floor ... has visitors from around the globe and offers regular posts with valuable links ...
(Date:7/28/2015)... ... July 28, 2015 , ... Darryl Worley’s Annual Tennessee ... the 14th year of raising money for the Darryl Worley Foundation. Worley will ... year’s main concert Saturday, Oct. 3. , This year’s concert will have a ...
Breaking Medicine News(10 mins):Health News:North Carolina Retirement Community Re-Launches Intergenerational Programming with Onsite Daycare Center 2Health News:North Carolina Retirement Community Re-Launches Intergenerational Programming with Onsite Daycare Center 3Health News:North Carolina Retirement Community Re-Launches Intergenerational Programming with Onsite Daycare Center 4Health News:National Association of Professional Women Inducts Susan Bentley, Owner of Women's Wellness Options, Into its VIP Woman of the Year Circle 2Health News:Announcing ProFont Cursive from FCPX Effects developer Pixel Film Studios 2Health News:Triumph Modular Launches Refreshed Modular Building Industry Website 2Health News:Worley’s 14th Tennessee River Run Will Host Wade Hayes, Lorrie Morgan, Tracy Lawrence and Others 2Health News:Worley’s 14th Tennessee River Run Will Host Wade Hayes, Lorrie Morgan, Tracy Lawrence and Others 3
... losing the battle against senility since a group of ... effective drug to retard the aging process. ,Li ... scientists, said he and his colleagues have detected the existence, ... grape-stones, which cannot be produced by the human body.// ...
... reports from the US suggest that acupuncture is at ... of hard evidence on the safety of complementary and ... provide one of the first serious safety assessments on ... out acupuncture agreed to record any adverse events occurring ...
... it robs individuals of their bone strength without showing any ... and break easily, affects women and men, nearly half of ... eight men over age 50 will have an osteoporotic fracture ... can lead to chronic pain, loss of independence and, in ...
... goes - you are what you eat! Experts have now ... - they may be diet and vitamin-related. ,A ... E and folic acid, is detrimental to skin. One of ... the most common: C.// As one of three anti-oxidants, Vitamin ...
... new study suggests that flaxseed lowers female hormone levels and ... used for thousands of years - the fibres to make ... are rich in lignans, which resemble the female hormone oestrogen.// ... cancer and lignans may lower levels by blocking oestrogen synthesis. ...
... from the Mayo Clinic in Rochester, Minnesota Vitamin E is ... with hot flashes. Estrogen relieves hot flashes in most ... survivors because the hormone may stimulate breast cancer growth.// ... flashes and other symptoms of menopause, and is approved for ...
Cached Medicine News:
Irrigating Cystotome, Straight, 25 g. Overall length 15 mm. 5/box....
Irrigating Cystotome, formed, 25 g., 12 mm curved tip. Overall length 14 mm. 5/box....
Scleral Blade tip 5700 style, straight. Dimensions: 15.2 mm (L) x 3.4 mm (W). Cut: 2.7 mm....
Needle Knife, straight, full handle, non-reflective, 0.74 mm width....
Medicine Products: