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Avalon Pharmaceuticals Announces Positive Interim Results For,AVN944 Phase I Trial

inties, in particular, related to clinical progress in the development of AVN944. Such statements reflect the current views of Avalon management and are based on certain assumptions. Actual results could differ materially from those currently anticipated as a result of a number of factors, risks and uncertainties including the risk that AVN944 will not progress successfully in its clinical trials, and other risks described in our SEC filings. There can be no assurance that our development efforts will succeed, that AVN944 will receive required regulatory clearance or, even if such regulatory clearance is received, that any subsequent products will ultimately achieve commercial success. The information in this Release should be read in conjunction with the Risk Factors set forth in our 2006 Annual Report on Form 10-K and updates contained in subsequent filings we make with the SEC.

    Contacts:

    Avalon Pharmaceuticals, Inc.                  Russo Partners, LLC

    David D. Muth                                 Wendy Lau (Media)

    Executive Vice President                      Tel: (212) 845-4272

    Chief Business Officer

    Tel: (301) 556-9900                           The Trout Group LLC

    Fax: (301) 556-9910                           Chad Rubin (Investors)

    Email:                       Tel: (646) 378-2947

info@avalonrx.com

CONTACT: David D. Muth, Executive Vice President of AvalonPharmaceuticals, Inc., +1-301-556-9900, or fax, +1-301-556-9910,; or media, Wendy Lau of Russo Partners, LLC,+1-212-845-4272, for Avalon Pharmaceuticals, Inc.; or investors, ChadRubin, Chief Business Officer of The Trout Group LLC, +1-646-378-2947 info@avalonrx.com

Web site: http://www.avalonrx.com/

Ticker Symbol: (NASDAQ-NMS:AVRX)

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