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Auxilium Announces New Data That Show Total Testosterone Blood,Levels Increase Significantly Following Switch from AndroGel(R) to,Testim(R)

estosterone (FT), and the presence of hypogonadal symptoms (libido, energy levels, and erectile function) were compared pre-and post-substitution for each form of therapy.

Prior to gel substitution, patients initially treated with AndroGel had mean T and FT levels of 314ng/dl and 10.2pg/ml, respectively, and total testosterone levels were below 300ng/dl in 57 percent of patients. Among patients who were initially treated on Testim, the mean T and FT levels were 444ng/dl and 14.6pg/ml, respectively, and total testosterone levels were below 300ng/dl in 18 percent of men.

    Following testosterone gel substitution:


    -- Total testosterone levels increased significantly following a switch

       from AndroGel to Testim, but not from Testim to AndroGel.


    -- The mean increase in T and FT was 174ng/dl (p=0.003) and 3.3pg/ml

       (p=0.14), respectively, among men switched to Testim, and 1.0ng/dl

       (p=0.9) and 0.3pg/ml (p=0.9), respectively, among men switched to

       AndroGel.


    -- Hypogonadal symptoms improved in 76 percent of men who underwent a

       brand substitution following an initial inadequate response.

About Hypogonadism

Low testosterone ("Low T"), or hypogonadism, is a medical condition caused by disease or damage to the testicles, hypothalamus, or pituitary gland that inhibits hormone secretion and testosterone production. Physical signs of hypogonadism can include incomplete sexual development, body hair loss, reduced muscle bulk and increased body fat, height loss, low bone density and impaired sperm production. Symptoms associated with hypogonadism can include reduced sexual desire, depression, changes in mood, poor concentration, decreased energy and motivation, and increased sleepiness. A study in The International Journal of Clinical Practice was published in 2006 that showed 39% of men over 45 years of age have low testosterone (total testosterone levels below 300 ng / dL). We estimate that
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