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Auxilium Announces New Data That Show Total Testosterone Blood,Levels Increase Significantly Following Switch from AndroGel(R) to,Testim(R)

MALVERN, Pa., May 22, 2007 /PRNewswire-FirstCall/ -- Auxilium Pharmaceuticals, Inc. today announced that new data show improvements in symptoms of decreased libido, energy levels and erectile function in 76 percent of hypogonadal men after switching brands of testosterone replacement gel therapy. Total testosterone levels increased significantly in patients who switched to Auxilium's Testim(R) 1% (testosterone gel) following suboptimal response to Solvay S.A.'s Androgel(R) (testosterone gel) 1%, according to research presented today at the annual meeting of the American Urological Association, the largest meeting in the world of urology health care professionals, in Anaheim, California.

In a retrospective study conducted at , records of 370 hypogonadal men on once-daily testosterone gel replacement therapy (Testim or AndroGel) were reviewed to identify patients who could be evaluated for the efficacy of substitution to the alternate brand of therapy due to an initial suboptimal biochemical or symptomatic response, adverse effect or patient preference.

"Patients using testosterone replacement gel therapy sometimes will fail to respond to their current treatment, resulting in persistent hypogonadal symptoms and a sub-optimal increase in testosterone blood levels," said Larry I. Lipshultz, M.D., Professor of Urology and Chief of the Division of Male Reproductive Medicine and Surgery at . "These data support changing testosterone gel preparations among initially unresponsive patients prior to abandoning or considering more invasive testosterone replacement therapy."

Study Design and Key Findings

Of the 370 records of hypogonadal men that were identified on testosterone gel therapy, 70 (19%) underwent a brand substitution in testosterone gel treatment. Eighty-one percent switched from Androgel to Testim, and 19 percent switched from Testim to Androgel. Total serum testosterone (T), free t
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