Navigation Links
Aspreva and Roche Announce Preliminary Results for Phase III Study,Evaluating CellCept in Lupus Nephritis

VICTORIA, BC, Canada and BASEL, Switzerland, June 27 /CNW/ - Aspreva Pharmaceuticals Corporation (NASDAQ: ASPV; TSX: ASV) and Roche today released preliminary results for a clinical trial comparing CellCept (oral mycophenolate mofetil, MMF) to intravenous cyclophosphamide (IVC), which is the current standard of care, for inducing treatment response in the induction phase of patients suffering from lupus nephritis.

Although response rates were similar in both arms, the trial did not meet its primary objective of demonstrating that MMF was superior to IVC in inducing treatment response in this disease. The results relate to the induction phase of this study, which was designed to measure treatment response in patients after 24 weeks of induction therapy with 185 patients in the MMF arm and 185 in the IVC arm. The results indicate similar treatment responses with 56.2% in the MMF arm and 53% in the IVC arm were observed. Additional analyses are ongoing to determine the potential for a regulatory submission and Aspreva plans to present the final results at an appropriate scientific forum.

Based on preliminary analysis, it appears that, in general, the adverse events experienced by patients in both arms of the study are consistent with those observed in lupus nephritis patients receiving immunosuppressive therapy. Overall incidence of adverse events was comparable in both treatment arms. Aspreva will host a conference call today at 9:30 a.m. ET (6:30 a.m. PT) to discuss these preliminary results.

About Lupus Nephritis

Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disease that causes the body to attack its own tissues and joints. Lupus nephritis, considered life-threatening, but rare, is the most serious manifestation of SLE. If left untreated, it can lead to kidney failure, need of dialysis, and potentially death. It is a complicated disease as patients typic
'"/>




Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Lupus Foundation of America Statement on Results for Clinical Study of CellCept Released by Aspreva Pharmaceutical Company
2. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
3. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
4. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
5. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
6. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
7. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
8. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
9. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
10. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
11. Protox Announces Positive Clinical Data from Prostate Cancer Study
Post Your Comments:
(Date:8/29/2014)... , Aug. 29, 2014 Diseases largely eradicated ... generation ago are returning. Measles was declared eliminated in ... 2014 as of August 15—the highest incidence in 20 ... health department declared whooping cough a problem of ... getting sick and dying from these preventable diseases—in part ...
(Date:8/29/2014)... , Aug. 29, 2014  Abaxis, Inc. (NasdaqGS: ... point-of-care blood instrumentation and consumables to the medical, research ... , Chairman and Chief Executive Officer, will present at ... Conference 2014 on Tuesday, September 9, 2014 at 12:30 ... Omni Berkshire Place Hotel in New York ...
(Date:8/29/2014)... 29, 2014 , Industry ... the inaugural Tweetchat taking place in real-time at ... organised by UBM Live , announces the ... a first of its kind global industry-wide Tweetchat ... supply chain, aimed to stimulate conversations on key ...
Breaking Medicine Technology:Vaccines at the Crossroads: Outbreaks On the Rise Across America 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 3Abaxis, Inc. to Present at CL King's 12th Annual Best Ideas Conference 2014 2CPhI Worldwide to Host #CPhIChat Provoking Debate on the Future of Pharma 2CPhI Worldwide to Host #CPhIChat Provoking Debate on the Future of Pharma 3
(Date:8/30/2014)... India (PRWEB) August 30, 2014 Removecomplaints.net, ... reputation management industry, has announced to offer guarantee of ... decided to offer this guarantee because of its tremendous ... than 200 clients from all over the world and ... extremely good job. , On being asked about ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 LiveStreamingFitness.com, a company ... as other healthy lifestyle resources, is proud to announce it ... resources for at home fitness solutions by ABC’s Good Morning ... featured story on ABC’s Good Morning America, “Live Streaming Fitness ... can streamline your day by streamlining your workout…to boot camp ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 Jake W., 18, ... while in the Back2Basics Outdoor Adventures transition program ... finish high school so I can actually start on a ... and math, and I'm done.” , He has six months ... Back2Basics program. Most clients choose to continue on to the ...
(Date:8/30/2014)... McLeod's Sunset Park Auto Service , ... with strong ties to the community celebrates sixty years in ... they have been chosen by The Tampa Tribune’s ... , Tim McLeod’s father, Norris (most know him as ... Although his son, Tim runs the day to day, taking ...
(Date:8/30/2014)... Final Cut Pro X plugin ... plugin from Pixel Film Studios. , “The TrasGhost plugin ... to tell their scary story in a suspenseful way.” ... will make their audience scream with this bone chilling ... users can awaken evil spirits with over 40 action ...
Breaking Medicine News(10 mins):Health News:Removecomplaints.net Announces Guaranteed Complaints Removal Services 2Health News:LiveStreamingFitness.com is New Trend In Fitness 2Health News:McLeod's Sunset Park Auto Service Celebrates 60 Years Honored with Best of South Tampa 2Health News:Pixel Film Studios Released TransGhost Plugin for Final Cut Pro X Today 2Health News:Pixel Film Studios Released TransGhost Plugin for Final Cut Pro X Today 3
... OH (May 29, 2012) A great deal has been ... Women,s Health Initiative (WHI) were published on July 9, 2002. ... women using hormone therapy (HT). The 27,000 women were prescribed ... 7 years, respectively. Researchers expected to find that hormones ...
... the death toll is relatively low for people who ... severe, life-long consequences for brain function. TBI can impair ... lead to dramatic personality changes. And long-term medical treatment ... commissioned by the United States Air Force, Prof. Chaim ...
... Seoul, South Korea, May 29, 2012 -- The discovery ... an Israeli-South Korean scientific team to conduct a genetic analysis ... virus (HBV) genotype C2 sequence common in Southeast Asia. ... used as a model to study the evolution of chronic ...
... May 29, 2012 -- The American College of Physicians (ACP), ... Million Hearts, a public-private sector initiative that aims to prevent ... Hearts has two primary goals: Empowering Americans ... reducing sodium and trans fat consumption. This can reduce the ...
... There is a correlation between high levels of the environmental ... abdomen. This is shown in a new study published today ... already known to increase the risk of diabetes and high ... (visceral fat) is considerably more dangerous that fat near the ...
... HealthDay Reporter , MONDAY, May 28 (HealthDay News) -- Women ... might be increasing their risk for breast cancer, Danish researchers ... highest among women who describe themselves as "morning" people rather ... 20 percent of women in modern societies have night shift ...
Cached Medicine News:Health News:Diabetes drug could be a promising therapy for traumatic brain injury 2Health News:Diabetes drug could be a promising therapy for traumatic brain injury 3Health News:16th-century Korean mummy provides clue to hepatitis B virus genetic code 2Health News:ACP joins Million Hearts to help save lives from preventable heart attacks and strokes 2Health News:PCB can increase risk of abdominal fat 2Health News:Night Shift Might Boost Women's Breast Cancer Risk: Study 2Health News:Night Shift Might Boost Women's Breast Cancer Risk: Study 3Health News:Night Shift Might Boost Women's Breast Cancer Risk: Study 4
This popular post op shoe provides quality care at an outstanding value. The semi-rigid outsole provides stability and minimizes flexure....
... Bird and Cronin, ... manufacturer of Patient Footwear, ... Patient Care Products. Our ... highest quality and available ...
... The AirHeel™ is specifically designed to treat Achilles ... located under the foot arch and in back ... with every step to help reduce swelling and ... neoprene fabric and is simple to apply ...
... An excellent preventative/thera-peutic device for ... Helps dampen vibration and shock ... motion. Provides relief from painful ... pad is easily detachable from the ...
Medicine Products: