Navigation Links
Arterial Plaque Significantly Reduced in Women Age 50-59 Taking,Hormones, Says New Analysis of Women's Health Initiative Data

Fourth Study to Indicate that Early Use of Estrogen May be Cardio-Protective

PHOENIX, June 20, 2007 /PRNewswire-USNewswire/ -- A new analysis of Women's Health Initiative data published in the New England Journal of Medicine, shows significant reduction in calcified plaque for women aged 50 to 59 using hormone therapy (HT) compared with women taking a placebo. This is the first time the relationship between estrogen therapy and coronary artery calcium (CAC) has been evaluated in a randomized trial.

The amount of CAC is now well-recognized as a strong predictor of future heart attacks and other coronary events. Using cardiac CT scans, CAC was measured in 1064 WHI women. After adjustment for other coronary risk factors, the risks of having mild-to-moderate CAC were 20 to 30 percent lower and the risks of severe CAC were 40 percent lower in the group of women assigned to the active HT group compared to those receiving placebo. Even more impressive was the finding that mild-to-moderate CAC scores were 40 to 50 percent lower and severe CAC was 60 percent lower in those women who were actually taking their study medications regularly.

"This is the fourth peer-reviewed re-analysis of WHI data to suggest that estrogen may be cardio-protective for younger women," said Dr. S. Mitchell Harman, Director of the Kronos Longevity Research Institute (KLRI). The Institute is conducting the Kronos Early Estrogen Prevention Study (KEEPS), a randomized, controlled, double-blinded trial of 720 recently menopausal women at nine study centers across the United States. The KEEPS is designed to provide prospective data on the risks and benefits of early menopausal HT, particularly as it relates to the progression of atherosclerosis. "The new findings from the WHI continue to support the KEEPS hypothesis that hormones may be good early, but bad late," Dr. Harman said.

This latest study follows an April article in th e Journal of the American Medical Association, which found a 24 percent reduction in risk for coronary heart disease in women starting hormone therapy less than ten years after menopause. The JAMA study also found a 30 percent reduction in over-all deaths among women aged 50-59 using HT.

An earlier re-analysis of WHI data, summarized in articles in the Journal of Women's Health and the Archives of Internal Medicine in early 2006, also indicated that estrogen may be cardio-protective for younger women. The Women's Health Initiative was halted in July 2002 due to over-all elevated risks.

"These findings lend further support to the theory that estrogen may slow early stages of plaque build-up and lead to less 'hardening' of the arteries supplying blood flow to the heart," said Dr. JoAnn Manson, from Brigham and Women's Hospital in Boston. Dr. Manson is the lead physician who contributed to the "Estrogen Therapy and Coronary Artery Calcification" study. She is also the lead investigator for the KEEPS trial at the study center in Boston.

Interviews are available by the investigators at all nine KEEPS study centers:

    -- Albert Einstein College of Medicine of Yeshiva University/Montefiore

       Medical Center, Bronx, NY

    --  College of Physicians and Surgeons, New York, NY

    -- Harvard Medical School/Brigham and Women's Hospital, Boston, MA

    -- Kronos Longevity Research Institute, Phoenix, AZ

    -- Mayo Clinic College of Medicine, Rochester, MN

    -- University of California-San Francisco/Center for Reproductive Health,

       San Francisco, CA

    -- University of Utah School of Medicine, Salt Lake City, UT

    -- University of Washington School of Medicine, Seattle, WA

    -- Yale University College of Medicine, New Haven, CT

CONTACT: Lisa Hanna, +1-202-466-9633, , forKronos Longevity Research Institute lisa@turnerstrategies.com

Terms and conditions of use apply
Copyright © 2007 PR Newswire Association LLC. All rights reserved.
A United Business Media Company


'"/>




Related medicine technology :

1. Gilead Announces Presentation of Long-Term Data for Ambrisentan, a Potential Treatment for Patients With Pulmonary Arterial Hypertension
2. REACH Registry Demonstrates That Multiple Arterial Disease Locations Sharply Increase the Risk of Major CV Events in Outpatients With Atherothrombosis
3. Evidence of Nanoparticles Found in Plaque-Filled Arteries
4. CSL Therapy That Mimics “Good” Cholesterol May Reduce Plaque Volume in Coronary Arteries
5. CSL Therapy That Mimics Good Cholesterol May Reduce Plaque Volume in Coronary Arteries
6. Calcium Plaque Build-up in the Arteries Leads to Coronary Heart Disease in Multi-Ethnic Groups
7. Prexige Study Shows Significantly Less Impact on Blood Pressure Than Ibuprofen in Osteoarthritis Patients with Controlled Hypertension
8. Lumiracoxib Study Showed Significantly Less Impact on Blood Pressure Than Ibuprofen in Osteoarthritis Patients with Controlled Hypertension
9. Actemra (tocilizumab) Significantly Improves Symptoms of Rheumatoid Arthritis Compared to a Current Standard of Care
10. Next Safety, Inc.s Innovative Drug Delivery System Will Replace Cigarettes and Significantly Advance Pulmonary Medication Delivery
11. Ivivis PEMF Technology Significantly Improves Neuron Survival in Parkinsons Disease Model, Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/27/2017)... for their devotion to personalized service, SMP Pharmacy Solutions announces ... the South Florida Business Journal,s 50 Fastest-Growing Companies, and listed ... national specialty pharmacy has found its niche.  To that end, ... honored by SFBJ as the 2017 Power Leader in Health ... his award in October, Bardisa said of the three achievements, ...
(Date:9/23/2017)... , Sept. 22, 2017 Janssen Biotech, ... complete response letter from the U.S. Food and Drug ... approval of sirukumab for the treatment of moderately to ... indicates additional clinical data are needed to further evaluate ... to severely active RA. ...
(Date:9/19/2017)... 19, 2017   ZirMed Inc ., a recognized leader ... that it has been ranked #1 by its users for ... Rankings 2017 User Survey. ZirMed was recognized as the top-ranked ... and medical centers over 200 beds and holds one of ... user survey history. ...
Breaking Medicine Technology:
(Date:10/13/2017)... , ... October 13, 2017 , ... ... throughout Arkansas that offers insurance and financial preparation services, is providing an update ... City Rescue organization. , Rock City Rescue is a locally recognized nonprofit that ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... established the certification process to promote standards of excellence for the field of ... scheduled for March 22 – 25, 2018 in Orlando, Florida at the Omni ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes ... a mock evacuation of the facility as part of a disaster drill on October ... Hose EMS and Shelton City Emergency Manager, as well as the Connecticut Long ...
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids ... sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited ... all ages; it is a non-competitive, non-timed event, which is all about having fun ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to ... to save lost souls in the Philippines. “The Journey: From the Mountains to the ... teacher of the Bible. She has taught all ages and currently teaches a class ...
Breaking Medicine News(10 mins):