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Arrowhead Subsidiary Calando Pharmaceuticals Publishes Study,Showing Anti-Cancer Effect with Lead RNAi Candidate

PASADENA, Calif.--(BUSINESS WIRE)--Apr 3, 2007 - Arrowhead Research Corporation (NASDAQ: ARWR) announced the publication by its majority-owned subsidiary Calando Pharmaceuticals, Inc. of a study demonstrating the anti-proliferative effect of the siRNA sequence selected as the therapeutic component of its lead anti-cancer compound, CALAA-01.

The paper, entitled "Potent siRNA Inhibitors of Ribonucleotide Reductase Subunit RRM2 Reduce Cell Proliferation In vitro and In vivo", was published in Clinical Cancer Research, a journal published by the American Association of Cancer Research (AACR). This paper describes how Calando's proprietary siRNA duplex demonstrated silencing of the target gene, RRM2, and reduced cell proliferation across multiple species and cancer types, both in cell culture and in whole animals. These findings confirm that this duplex is a promising candidate for therapeutic development.

"The paper reports some of the great progress being made at Calando," said R. Bruce Stewart, Chairman and CEO of Arrowhead. "We believe that siRNA will be one of the corner stones of cancer treatment in the future".

"These studies demonstrate the potential for this siRNA duplex to have a strong anti-tumor effect," said John Petrovich, Calando's Chief Executive Officer. He further added that Calando has filed for patent protection on several siRNA duplexes against the RRM2 target and has licensed patents from Alnylam Pharmaceuticals to enable it to develop and commercialize an RNAi therapeutic against this target.

Further information about Calando can be found at www.calandopharma.com.

About Arrowhead Research Corporation

Arrowhead Research Corporation (www.arrowheadresearch.com) is a publicly-traded nanotechnology company commercializing new technologies in the areas of life sciences, electronics, and energy. Arrowhead is building value for shareholders through the progress of ma
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