Navigation Links
Arrowhead Subsidiary, Insert, Publishes Interim Phase I Data from,Human Clinical Trials for New Cancer Drug

PASADENA, Calif.--(BUSINESS WIRE)--Jun 1, 2007 - Arrowhead Research Corporation (Nasdaq:ARWR) announced today that interim Phase I data has been published in the 2007 American Society for Clinical Oncology Proceedings (ASCO) (Abstract ID 32638). The data are from an ongoing Phase I clinical study designed to evaluate the safety, tolerability, and pharmacokinetics of its lead anti-cancer drug candidate, IT-101, in patients with inoperable or metastatic tumors. IT-101 is a conjugate of the potent anti-cancer drug camptothecin and Insert's proprietary drug delivery technology, Cyclosert(TM).

"The interim IT-101 study results look very promising," stated R. Bruce Stewart, Chairman of Arrowhead. "We were encouraged to see patients who have failed other chemotherapies complete the whole six cycles of treatment without disease progression."

The abstract's authors state that the stable disease rate, although not yet conclusive, is consistent with promising efficacy. In general, IT-101 was well tolerated and pancytopenia was the dose limiting toxicity. Patients that have completed the six cycle treatment regimen and showed stable disease or better are expected to continue to receive treatment on a compassionate care basis. The first person to enter the trial, a pancreatic cancer patient, is stable after 10 months.

"The type of dose limiting toxicity identified is consistent with the expectation for a camptothecin derivative," said Dr. Thomas Schluep, Chief Scientific Officer at Insert. "We are encouraged that, at dose levels that have promising efficacy, we have not seen some of the other deleterious side effects commonly experienced by patients receiving camptothecin class drugs."

Pharmacokinetics data were favorable and consistent with results from preclinical animal studies. In the patients studied, IT-101 showed longer half life, lower clearance and lower volume of distribution than seen in pati
'"/>




Page: 1 2 3

Related medicine technology :

1. Arrowhead Subsidiaries Insert & Calando Present Data on Cyclosert Drug Delivery System at AACR Meeting
2. Arrowhead Subsidiary Calando Pharmaceuticals Publishes Study Showing Anti-Cancer Effect with Lead RNAi Candidate
3. Arrowhead Subsidiary, Calando Pharmaceuticals Publishes Study on Targeted, Systemic Delivery of siRNA
4. CytRx Announces RNAi Delivery Nanoparticle Technology Exclusively Licensed to Subsidiary, RXi Pharmaceuticals, Described in Peer-Reviewed Journal
5. Trophos Publishes ALS Article in Journal of Pharmacology and Experimental Therapeutics
6. New England Journal of Medicine Publishes New Data on Gardasil, Mercks Cervical Cancer Vaccine
7. The Lancet Publishes PREVAIL Study Results Showing Lovenox Superiority Over Unfractionated Heparin for Reducing the Risk of Venous ThromboEmbolism in Patients With Acute Ischemic Stroke
8. MedImmune Publishes New Data in Nature Immunology Demonstrating The Role HMGB1 May Play in Systemic Autoimmune Diseases
9. Calando Pharmaceuticals Publishes Study Showing Anti-Cancer Effect with Lead RNAi Candidate
10. Medical Journal Publishes First Large-Scale Survey Revealing Experiences of IPF Patients
11. Calando Pharmaceuticals Publishes the First Non-Human Primate Study on Targeted, Systemic Delivery of siRNA in National Academy of Sciences Journal
Post Your Comments:
(Date:9/3/2015)... 2015 About cardiovascular implants ... narrowing or blockage of blood vessels. Cardiac disease ... high cholesterol, and high blood pressure. Coronary artery ... heart failure are some of the major cardiac ... especially coronary arteries, is one of the most ...
(Date:9/3/2015)... , Sept. 3, 2015 About dry eye syndrome ... eyes due to deficient tear production or quick tear ... of two types: aqueous tear deficient dry eye and ... lacrimal glands do not produce enough tears, whereas meibomian ... secrete lipids to slow tear evaporation and maintain tear ...
(Date:9/3/2015)... 2015  WellCare Health Plans, Inc. (NYSE: WCG ... vice president and chief financial officer, is scheduled to ... on Wednesday, September 9, 2015, at 9:25 a.m. Eastern ... In addition, a replay of the webcast will be ... the live broadcast and the replay will be available ...
Breaking Medicine Technology:Global Cardiovascular Implants Market 2015-2019 2Global Dry Eye Syndrome Market 2015-2019 2
... 2012 QRxPharma (ASX: QRX and OTCQX: QRXPY) announced ... healthy volunteers for MoxDuo® CR, a controlled-release Dual-Opioid® utilising ... MoxDuo CR formulation, encompassing both sustained delivery technology as ... designed to provide at least 12 hours of analgesia ...
... ® and Lung Cancer Alliance hailed the ... conducted by Milliman Inc., an internationally recognized actuarial ... olds at high risk for lung cancer with ... lives, and at lower cost than commonly used screening ...
Cached Medicine Technology:QRxPharma Successfully Completes Phase 1 Studies for MoxDuo® CR 2QRxPharma Successfully Completes Phase 1 Studies for MoxDuo® CR 3QRxPharma Successfully Completes Phase 1 Studies for MoxDuo® CR 4Legacy® and Lung Cancer Alliance Hail the Release of New Study Showing Lung Cancer Screening is Cost Effective 2Legacy® and Lung Cancer Alliance Hail the Release of New Study Showing Lung Cancer Screening is Cost Effective 3
(Date:9/3/2015)... ... September 03, 2015 , ... ... Amerinet Inc., a leading national healthcare solutions organization, to provide electronic medical record ... Through this agreement, Amerinet members will receive negotiated pricing on E-Volve Health’s Epic ...
(Date:9/3/2015)... ... September 03, 2015 , ... DriButts, a ... partnered with Slingshot® Product Development Group to manufacture a long-lasting reusable diaper for ... with DriButts plans to bring 600 DriButts Diapers to rural areas of Haiti ...
(Date:9/3/2015)... , ... September 03, 2015 , ... ... community to be situated at 4400 Columbine Drive in Bellingham, Washington. Silverado Bellingham, ... and has been carefully designed to serve up to 80 people living with ...
(Date:9/3/2015)... ... 03, 2015 , ... Today, Splashtop announced availability of its ... of the LANDESK One Partner program. Splashtop remote desktop solutions complement ... experience in remote access and control:, , LANDESK customers ...
(Date:9/3/2015)... ... September 03, 2015 , ... Girl’s Night Out to benefit Core Compassion Project ... 6205 Kate Road in Monroe, North Carolina. The event food will be ... function, Kate Clyde’s offers off-premise catering and event services from casual to elegant. They ...
Breaking Medicine News(10 mins):Health News:E-Volve Health to Offer EMR Consulting Solutions to Amerinet Members 2Health News:DriButts Diapers Rely on Slingshot Help in Haiti 2Health News:DriButts Diapers Rely on Slingshot Help in Haiti 3Health News:Site Dedication Ceremony to Celebrate New Silverado Memory Care Community 2Health News:Splashtop Partners with LANDESK to Deliver High Performance Remote Access and Remote Support to and from Mobile Devices and Chromebook 2Health News:Splashtop Partners with LANDESK to Deliver High Performance Remote Access and Remote Support to and from Mobile Devices and Chromebook 3Health News:Splashtop Partners with LANDESK to Deliver High Performance Remote Access and Remote Support to and from Mobile Devices and Chromebook 4Health News:Girl’s Night Out, with Food From Kate Clyde's Catered Creations, to Benefit Core Compassion Project 2
... CHICAGO, Nov. 30 Today at the Radiological ... Systems USA announced,that it has expanded its Synapse ... tele-RIS capabilities.(1) The company has also established a,partnership ... will,provide hosted RIS and off site archiving to ...
... new batch of video iPod repairs just announced at the website ipodjuice.com ... ... San Antonio, TX (PRWEB) November 30, 2008 -- With the 5th Generation ... LTD has added several new repair products and services to their website ...
... Siemens Healthcare,( www.siemens.com/healthcare ) will highlight workflow enhancements ... at the 94th Scientific Assembly and Annual Meeting ... November 30 to December 5 at,McCormick Place (Booth ... (Logo: ...
... those with fewer resources , , FRIDAY, Nov. 28 (HealthDay News) ... likely to donate a liver or kidney for transplant than ... national study by Harvard University researchers found that almost 17 ... the time of hospitalization. , In contrast, less than one ...
... Nov. 28 Streamline Health Solutions,Inc. (Nasdaq: STRM ... quarter of fiscal year 2008 ended October 31, 2008 on ... and webcast to discuss,the results on Monday, December 15, at ... conference call to provide additional time for,completion of the necessary ...
... unfit for kids, report claims , , FRIDAY, Nov. 28 ... ponies containing the controversial compounds called phthalates. , Toy ... pet animals that pose a choking hazard. , Consumers ... all these toys are in stores this holiday season, ...
Cached Medicine News:Health News:Fujifilm Sees Significant Growth of Managed Services Business 2Health News:Fujifilm Sees Significant Growth of Managed Services Business 3Health News:Several New 5th Generation iPod Video Repairs Announced Today 2Health News:Siemens Focuses on Role-Based, Context-Sensitive and Knowledge-Driven Solutions 2Health News:Siemens Focuses on Role-Based, Context-Sensitive and Knowledge-Driven Solutions 3Health News:Siemens Focuses on Role-Based, Context-Sensitive and Knowledge-Driven Solutions 4Health News:Siemens Focuses on Role-Based, Context-Sensitive and Knowledge-Driven Solutions 5Health News:Uninsured Likely Organ Donors, But Not Recipients 2Health News:Streamline Health Reschedules Q3 Financial Results Release and Conference Call for Monday, December 15, 2008 2Health News:Beware of Toxic Toys This Holiday Season 2Health News:Beware of Toxic Toys This Holiday Season 3
Specimen-ID™, a Positive Specimen Identification System, assures the permanent link at the bedside between patient and laboratory specimen to prevent sample identification errors....
wCareMed™ utilizes barcode scanning technology to support medication administration. It is a simple to use point of care application that provides access to patient information on a lightweight,...
... Korchek Technologies CareChek Rx ... barcode technology, Windows CE ... integrated scanners (to perform ... the bedside) and an ...
... conjunction with the AutoPPI barcoded wristband, manages ... a specific patient. The system ensures that ... correct patient and provides printed medication delivery ... keeps a record of the caregiver, location ...
Medicine Products: