Navigation Links
Arrowhead Subsidiaries Insert & Calando Present Data on,Cyclosert Drug Delivery System at AACR Meeting

Novel Systems May Provide Cancer Patients With Improved Potential to Battle Their Disease

PASADENA, Calif., April 16, 2007 /PRNewswire-FirstCall/ -- Arrowhead Research Corporation announced today that two of its majority-owned subsidiaries, Insert Therapeutics Inc. and Calando Pharmaceuticals Inc., are presenting data at the 2007 American Association for Cancer Research (AACR) Annual Meeting. The presentations summarize the latest research findings on two anticancer therapies currently under development. Both therapies employ a novel delivery system called Cyclosert(TM), developed at the and exclusively licensed to Insert Therapeutics and, through Insert, to Calando.

"We are pleased that our companies have outstanding data to present at this prestigious conference," said R. Bruce Stewart, Chairman and Chief Executive Officer of Arrowhead. "We see great promise going forward for the treatment of cancer using our delivery system."

Cyclosert is the first nanoparticle drug transport platform to be designed de novo and synthesized specifically to overcome limitations in existing technologies used for the systemic transport of therapeutics to targeted sites within the body. Based on small cyclic repeating molecules of glucose called cyclodextrins, Cyclosert promotes the ability of cytotoxic drugs to inhibit the growth of human cancer cells while reducing toxicity and remaining non-immunogenic at therapeutic doses. In particular, the system is designed to reduce the toxicity of the drugs until they actually reach the targeted tumor cells where the active drug is released in a controlled fashion.

Insert's Chief Scientific Officer, Thomas Schluep, Sc.D., will present data from in vitro and animal studies using the Cyclosert system to deliver tubulysin A, a potent, but highly toxic, antitumor agent. In vitro studies have shown the tubulysin-Cyclosert conjugate to be effective against multiple human c
'"/>




Page: 1 2 3 4

Related medicine technology :

1. Arrowhead Subsidiary, Insert, Publishes Interim Phase I Data from Human Clinical Trials for New Cancer Drug
2. Arrowhead Subsidiary Calando Pharmaceuticals Publishes Study Showing Anti-Cancer Effect with Lead RNAi Candidate
3. Arrowhead Subsidiary, Calando Pharmaceuticals Publishes Study on Targeted, Systemic Delivery of siRNA
4. Dharma Therapeutics Shows IDDS Is Effective in Reducing Pain Associated With Insertion of an Intravenous Catheter in Their Phase 2 Clinical Trial
5. Pro-Pharmaceuticals Updates Progress of Clinical Trials & Davanat 505 (b)(2) Filings
6. Positive Clinical Results for DG041 Lead Product Development Highlights at deCODE R&D Event
7. Vastox Awarded £400,000 Grant to Support R&D at Carbohydrate Chemistry Facility
8. Modigene Announces Successful Completion of Pharmacokinetic & Pharmacodynamic Pre-Clinical Experiments for Proprietary Long-Acting Human Growth Hormone, Long-acting Interferon Beta and Long-acting Erythropoietin
9. Inovio Biomedicals DNA Delivery Technology Shows Safety and Enhances Gene Expression & Tumor Responses in Interim Melanoma Clinical Study Results
10. Cervarix, GSK Cervical Cancer Candidate Vaccine, Demonstrates 100 Percent Protection Against Precancerous Lesions Caused By Cancer-Causing Human Papillomavirus Types 16 & 18 for More Than Five Years
11. Calando Pharmaceuticals Announces Preclinical Efficacy and Safety Data of Targeted, Systemic Delivery of siRNA at AACR Annual Meeting
Post Your Comments:
(Date:7/2/2015)... BGI a annoncé aujourd,hui que son ... situé à Hong Kong ... Pathologists  (Collège des pathologistes américains, ou CAP). Les ... constituent le premier laboratoire clinique de ... du CAP en Chine, car il satisfait les ...
(Date:7/2/2015)... FORT LAUDERDALE, Fla. , July 2, 2015 ... & Co., is pleased to announce that its ... Inc. ("Insight Beverages") to Kerry Group plc (ISE: ... focused on taste and nutrition systems, as well ... food, beverage and pharmaceutical markets. Farlie Turner served ...
(Date:7/2/2015)... 26, 2015 Research and Markets( ... D Market by Analog, Application, End-User & by Region - ... offering. This market is projected to reach about ... in different applications and rising opportunities in countries such as ... Italy , and Brazil ...
Breaking Medicine Technology:BGI obtient la certification du Collège des pathologistes américains (CAP) 2Farlie Turner's Consumer Group Completes Sale of Insight Beverages to Kerry 2Vitamin D Market by Analog, Application, End-User & by Region - Global Trends & Forecast to 2020: Increasing Recommendation By Doctors & Associations 2Vitamin D Market by Analog, Application, End-User & by Region - Global Trends & Forecast to 2020: Increasing Recommendation By Doctors & Associations 3
(Date:7/3/2015)... ... July 03, 2015 , ... ... healthcare providers, has been retained to lead a national chief nursing officer ... top-ranked executive search firms in the healthcare industry, B. E. Smith has recently ...
(Date:7/3/2015)... ... 2015 , ... First Choice Emergency Room , the largest network of ... the new Medical Director of its Frisco facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:7/2/2015)... ... July 02, 2015 , ... sweetFrog Enterprises, LLC. is pleased to ... the first sweetFrog store located in Mississippi. The premium frozen yogurt chain was listed ... The store, located at 104 Railroad Avenue, New Albany, MS 38652, will have a ...
(Date:7/2/2015)... ... July 02, 2015 , ... When Walker ... at the University of Minnesota, they knew it would save the university energy ... an award-winning choice: the total energy savings after installation was an impressive 89 ...
(Date:7/2/2015)... ... July 02, 2015 , ... As Americans celebrate the Fourth of July ... cancer is on the rise. July is UV Safety Month, and physicians at American ... importance of getting skin checks. Experts say most skin cancers can be found early ...
Breaking Medicine News(10 mins):Health News:Jane Phillips Medical Center Retains B. E. Smith to Recruit New Chief Nursing Officer 2Health News:Jane Phillips Medical Center Retains B. E. Smith to Recruit New Chief Nursing Officer 3Health News:First Choice Emergency Room Announces Dr. Mariah N. Manzanares as Medical Director of Frisco, TX Facility 2Health News:First Choice Emergency Room Announces Dr. Mariah N. Manzanares as Medical Director of Frisco, TX Facility 3Health News:sweetfrog Opens First Location in Mississippi 2Health News:Kenall’s TekDek™ Helps University Achieve Award-Winning Energy Savings in Parking Structure Lighting Retrofit 2Health News:Local Physicians Warn of Holiday Health Hazards 2Health News:Local Physicians Warn of Holiday Health Hazards 3Health News:Local Physicians Warn of Holiday Health Hazards 4
... WINSTON-SALEM, N.C. Sept. 16, 2011 A study ... colleagues suggests that a high intake of calcium causes ... absorbers of the mineral. "High dietary intake of ... the explanation for this observation has been elusive," said ...
... THURSDAY, Sept. 15 (HealthDay News) -- The rate of new lung ... as it has for men in for years, a new U.S. ... 2.2 percent per year on average for women between 2006 and ... 2006, according to the U.S. Centers for Disease Control and Prevention. ...
... speaking on Capitol Hill today demonstrated that the Great ... older workers, although programs such as the federal Senior ... some valuable benefits to this disadvantaged demographic group. ... of National Employ Older Workers Week was titled, ...
... of young children admitted to hospitals or seen in ... dose of medication has risen dramatically in recent years, ... study. The rise in exposure to ... for Disease Control and Prevention has established the PROTECT ...
... Alzheimer,s diagnosis presents new challenges to the public, physicians and ... you want to know? How should doctors tell you your ... diagnosed Americans still in the workplace? Despite the ... effective interventions have been identified to stop the progression of ...
... , THURSDAY, Sept. 15 (HealthDay News) -- Men and women ... their eyelids appear to face a higher risk of heart ... new Danish research suggests. The link between the skin ... rather than a clear case of "cause and effect." ...
Cached Medicine News:Health News:Genetics may explain why calcium increases risk for prostate cancer 2Health News:Lung Cancer Rates Begin to Decline for U.S. Women 2Health News:Congressional briefing sheds light on poor seniors' employment struggles 2Health News:Congressional briefing sheds light on poor seniors' employment struggles 3Health News:Number of children poisoned by medication rising dramatically, study says 2Health News:Safeguards needed to prevent discrimination of early Alzheimer's patients in the workplace 2Health News:Cholesterol Deposits Around Eyes Linked to Heart Risk 2
... Complete procedure information to facilitate diagnostic ... monitor is a sterile, disposable device used ... nucleus during discography procedures. The device will ... display it in a digital format. The ...
Smith & Nephew's CDS System is developed exclusively for discography., Developed exclusively for discography, it is the first system designed to measure true disc pressure and record real-time proce...
The ACCU-DISC™ pressure monitoring system offers the advantage of accurate delivery of fluids to the body with the ability to monitor the pressure of those fluids in discography interpretation....
The °CureWrap is one-piece garment offers maximum available surface coverage, while avoiding the sterilized fields of operation....
Medicine Products: