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Array BioPharma Reports New Clinical Data on Its Anti-Inflammatory,Drugs

with no serious adverse events. In blood samples taken from these volunteers and stimulated ex vivo, ARRY-797 was shown to inhibit the production of IL-1beta, TNF-alpha and PGE2. This effect was pronounced, with greater than 90 percent inhibition, and long-lasting with greater than 50 percent inhibition at 24 hours at the highest dose. ARRY-797 met its objective in this study and has advanced into MAD studies in both normal volunteers and cancer patients with hematological malignancies.

"We are pleased that both ARRY-162, our first-in-class MEK inhibitor for inflammation, and ARRY-797, our potent p38 inhibitor, have met their initial clinical endpoints," said Kevin Koch, Ph.D., President and Chief Scientific Officer. "We look forward to demonstrating the advantages of using these oral drugs to treat patient populations that would benefit from the suppression of inflammatory cytokines."

About Inflammatory Disease

Inflammation is a natural biologic response to injury or infectious attack to the human body. Unregulated inflammation results in a broad range of conditions, most of which are classified by the tissue or organ where the inflammation occurs. These conditions include rheumatoid arthritis (RA) in the joint, psoriasis in the skin, chronic obstructive pulmonary disease in the lung, fibrotic disease in the liver and kidney, Crohn's disease in the intestine, congestive hear failure and arteriosclerosis in the arteries, among others. Currently, some of the most effective treatments for these diseases are injectable protein therapeutics, which have significant cost and patient compliance issues. Injectable protein therapeutics currently on the market - such as Enbrel(R), Remicade(R), Humira(R) and Kineret(R) - bind to and/or modulate the activity of the inflammatory cytokines TNF-alpha or IL-1 and are utilized for the treatment of RA, psoriasis and Crohn's disease.

About ARRY-162 / Targeting MEK for Inflammation

MEK is an enzyme t
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