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ArQule Announces Acceptance of Clinical Data on ARQ 197, c-Met,Inhibitor, for Oral Presentation at ASCO

are presented or published. Following is a list of the abstracts related to ARQ 197 and ARQ 501 that have been accepted at the ASCO and AACR meetings.

ASCO Abstracts

For oral presentation

-- A Phase 1 dose escalation study of ARQ 197, a selective inhibitor of the c-Met receptor in patients with metastatic solid tumors

For publication in ASCO proceedings

-- A Phase 2 study of ARQ 501 in combination with gemcitabine in adult patients with treatment naive, unresectable pancreatic adenocarcinoma

-- A Phase 2 dose multi-center, open-label study of ARQ 501, a checkpoint activator, in adult patients with persistent, recurrent or metastatic leiomyosarcoma (LMS)

AACR Abstracts

-- Pharmacokinetics of a novel PGA-ARQ 501 conjugate in mouse xenografts

-- Mass balance and characterization of the Metabolites of ARQ 501 ((beta)-lapachone), a checkpoint pathway activator in clinical development

-- Pharmacodynamic biomarkers for checkpoint pathway activator ARQ501 in a human colon xenograft model

-- Selective induction of necrotic cell death in cancer cells by (beta)-lapachone through activation of DNA damage response pathway

-- Evaluation of biomarkers for HGFR/c-Met inhibitor ARQ 197 in a human xenograft model

-- Functional chemogenomics approach to identify checkpoint pathway activators against cancer

-- Selective killing of cancer cells by activation of human checkpoint kinase 2

-- ARQ 197, a highly selective small molecule inhibitor of c-Met, inhibits invasive and metastatic growth of cancer cells

-- ARQ 197, a highly selective small molecule inhibitor of c-Met, with selective antitumor properties in a broad spectrum of human cancer cells

-- Broad spectrum anti-cancer activity of ARQ 197, a highly selective oral c-Met Inhibitor, in multiple xenograft models

-- Anti-metastatic activity of ARQ 197, a highly selective oral small molecule inhibitor of c-Met,
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