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ArQule Announces Acceptance of Clinical Data on ARQ 197, c-Met,Inhibitor, for Oral Presentation at ASCO

WOBURN, Mass.--(BUSINESS WIRE)--Mar 14, 2007 - ArQule, Inc. (NASDAQ: ARQL) today announced that the American Society of Clinical Oncology (ASCO) has accepted for oral presentation the Company's abstract for ARQ 197 (A Phase 1 Dose Escalation Study of ARQ 197, a Selective Inhibitor of the c-Met Receptor in Patients with Metastatic Solid Tumors) at the 43rd ASCO Annual Meeting, June 1-5, 2007, in Chicago. This presentation will describe findings from a Phase 1 trial with ARQ 197, a selective, small molecule inhibitor of the c-Met receptor tyrosine kinase, in cancer patients with a broad range of metastatic solid tumor types who had failed prior treatment regimens.

In addition, abstracts describing protocol design and patient recruitment as of January, 2007 in the Company's ongoing Phase 2 trials with ARQ 501 in leiomyosarcoma and pancreatic cancer have been accepted for publication in the ASCO Proceedings. The Company expects to announce further results from these trials, as well as from a Phase 2 trial in head and neck cancer, in mid-2007. ARQ 501 is an activator of the DNA damage response/checkpoint pathway regulated by the E2F-1 regulatory protein and is the lead product from the Company's Activated Checkpoint Therapy (ACT) platform.

The American Association for Cancer Research (AACR) has accepted eleven abstracts submitted by the Company in connection with AACR's 2007 Annual Meeting, April 14-18, 2007, in Los Angeles. The AACR abstracts are based on pre-clinical studies that cumulatively provide a rationale for the company's approaches to cancer therapy as embodied in its c-Met inhibition and DNA damage response/checkpoint activation platforms. They represent a broad scope of findings from in vitro (cell line) and in vivo (animal) experiments.

Consistent with the disclosure policies mandated by ASCO and AACR, ArQule will summarize the contents of these studies at the time the complete abstracts
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