( are acompelling factor to drive forth...)Antisense Pharma: Promising Phase IIb Results of Targeted Therapy,with AP 12009 in Recurrent Anaplastic Astrocytoma,Health

are a compelling factor to drive forth the clinical development of AP 12009 in high-grade glioma and in other solid tumors.” The American Society of Clinical Oncology provides an audio version of the poster discussion by Prof. Wong. The virtual meeting presentation can be found following this link: http://www.antisense-pharma.com/publications/f_publications.htm General Background on AP 12009 and TGF-beta 2 AP 12009 is an antisense drug - a phosphorothioate oligodeoxynucleotide - designed to selectively downregulate the production of transforming growth factor-beta 2 (TGF-beta 2) at the translational level. TGF-beta 2 plays a pivotal role as a multimodally acting cytokine by regulating key mechanisms of tumor progression. Immunosuppression, invasion and migration, proliferation and angiogenesis are simultaneously promoted in a variety of malignant tumors.This multiple impact on cancer cells is inhibited by AP 12009 (3, 4).

General Background on High-Grade Glioma Anaplastic astrocytoma and glioblastoma are the two most common forms of primary brain tumor, a diagnosis with high unmet medical need. Adults as well as children can be affected, although the age peak is at 45-65 years. Current therapies comprise surgery, radiation and/or chemotherapy. Despite recent advances the prognosis for these patients is still poor, with 94% dying within two years of initial diagnosis.

About Antisense Pharma GmbH Antisense Pharma is a biopharmaceutical company located in Regensburg, Germany. The company focuses on targeted therapies for malignant tumors and is dedicated to discovering and developing drugs based on antisense technology for worldwide commercialization. The agents specifically block the synthesis of key cancer proteins. Antisense Pharma has been honored with the Bavarian Innovation Award and the German Founders Award.

Literature (1) Bogdahn U., et. a
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