Navigation Links
Anti-TNF Golimumab Continues to Show Promise in Phase II Rheumatoid,Arthritis Study

Golimumab Demonstrated Sustained Improvement in Signs and Symptoms Of Moderate to Severe Rheumatoid Arthritis With One-Third of Patients Achieving Disease Remission at One-Year Mark

BARCELONA, Spain, 14 June 2007 – One-year data show nearly 75 percent of patients with moderate to severe rheumatoid arthritis (RA) receiving golimumab (CNTO 148) and methotrexate (MTX) experienced and maintained at least 20 percent improvement in arthritis symptoms (ACR 20). This was according to findings from a double-blind, placebo-controlled, dose-ranging Phase II study presented today at the European League Against Rheumatism (EULAR) Annual Congress of Rheumatology. The same study also showed that, on average, more than one-third of these patients achieved disease remission at one year as evaluated by Disease Activity Score 28 (DAS28) [DAS < 2.6].

Golimumab is a fully-human anti-TNF-alpha monoclonal antibody that targets and neutralizes both the soluble and the membrane-bound form of TNF-alpha. Developed by Centocor, Inc and Schering-Plough Corporation (NYSE: SGP), golimumab is being investigated for administration by both subcutaneous (SC) injection and intravenous (IV) infusion.

“The maintained therapeutic effect demonstrated by these results is very promising,” said Iain B. McInnes, FRCP, Ph.D., Professor of Experimental Medicine at the University of Glasgow; Honorary Consultant Rheumatologist, Centre for Rheumatic Diseases, Glasgow Royal Infirmary in Glasgow, United Kingdom, who serves as a lead investigator in a Phase III study of golimumab. “Physicians treating patients with RA are always looking for advanced medications that offer sustained efficacy to keep this serious, life-altering condition in remission.”

Data from the study showed that significantly greater percentages of patients treated with golimumab plus MTX achieved ACR 20, 50 and 70 responses (mark
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Study Continues to Show Patients With Myelodysplastic Syndromes Treated With Revlimid are Living Longer and Remaining Transfusion Independent
2. MediGene Announces Cancer-Fighting Virus Shows Promise in Early Clinical Trial
3. New Drugs in Multinational Study Show Promise in Fighting Drug-Resistant HIV
4. Beike Biotechnology Study Suggests Adult Stem Cells Show Promise for Peripheral Vascular Disease
5. Ceragenix Compound Shows Promise for Treating Lethal Cystic Fibrosis Infections
6. Trial Results with Intranasal Fentanyl Hold Promise for Treatment of Breakthrough Pain in Cancer
7. Merck at ASCO 2007: Spectrum of Studies Reinforces Promise of Erbitux for Colorectal and Head and Neck Cancer Patients
8. Investigational Drug Cediranib (AZD2171) Shows Promise in Patients With Recurrent Glioblastoma (GBM)
9. RTA 402 Shown to Inhibit STAT3 in Animal Model and Holds Significant Promise for Treating Breast Cancer
10. Alzheimers Drug Shows Promise in Fighting Cancer
11. Data on Telavancin and Micafungin Hold Promise of New Therapeutic Options in Fight Against Serious Infectious Disease

Post Your Comments:
(Date:11/6/2009)...- Caraco Pharmaceutical Laboratories, Ltd. (NYSE A...hthalmic solution, 0.5% following a final approval...r Sun Pharma,s Abbreviated New Drug Application (A...n the first day following patent expiration. This ...t to Acular® Ophthalmic Solution, 0.5%, from ...
(Date:11/5/2009)...tCall/ -- Osteotech, Inc. (Nasdaq: OSTE ), a lead...regenerative healing, today reported financial res...9. ,, "During the third quarter of 2009, our fo...roducts MagniFuse(TM) Bone Graft, FacetLinx(TM) F...fting," said Sam Owusu-Akyaw, President and Chief ...
(Date:11/5/2009)...tCall/ -- Helix BioPharma Corp. (TSX, FSE: "HBP" /...rial of Topical Interferon Alpha-2b for the treatm...nt enrollment, with the required 120th patient ran... and placebo-controlled Phase II trial is underway...nts participating in the trial self-administer act...
Breaking Medicine Technology:Caraco Pharmaceutical Laboratories, Ltd. Markets Generic Acular(R) Opthalmic Solution 2Osteotech Reports Third Quarter 2009 Financial Results 2Osteotech Reports Third Quarter 2009 Financial Results 3Osteotech Reports Third Quarter 2009 Financial Results 4Osteotech Reports Third Quarter 2009 Financial Results 5Osteotech Reports Third Quarter 2009 Financial Results 6Osteotech Reports Third Quarter 2009 Financial Results 7Osteotech Reports Third Quarter 2009 Financial Results 8Helix BioPharma Corp. Completes Enrollment in Its Phase II Trial of Topical Interferon Alpha-2b in Patients With Ano-Genital Warts 2Helix BioPharma Corp. Completes Enrollment in Its Phase II Trial of Topical Interferon Alpha-2b in Patients With Ano-Genital Warts 3Helix BioPharma Corp. Completes Enrollment in Its Phase II Trial of Topical Interferon Alpha-2b in Patients With Ano-Genital Warts 4Helix BioPharma Corp. Completes Enrollment in Its Phase II Trial of Topical Interferon Alpha-2b in Patients With Ano-Genital Warts 5Helix BioPharma Corp. Completes Enrollment in Its Phase II Trial of Topical Interferon Alpha-2b in Patients With Ano-Genital Warts 6Evidence for a New Genetic Link to Therapeutic Efficacy for Alzheimers Disease 13012 1Evidence for a New Genetic Link to Therapeutic Efficacy for Alzheimers Disease 13012 2Evidence for a New Genetic Link to Therapeutic Efficacy for Alzheimers Disease 13012 3Evidence for a New Genetic Link to Therapeutic Efficacy for Alzheimers Disease 13012 4SNICKERS 28R 29 Brand and David Arquette Make a Big Move to Help Feeding America Bar Hunger 51589 1SNICKERS 28R 29 Brand and David Arquette Make a Big Move to Help Feeding America Bar Hunger 51589 2SNICKERS 28R 29 Brand and David Arquette Make a Big Move to Help Feeding America Bar Hunger 51589 3SNICKERS 28R 29 Brand and David Arquette Make a Big Move to Help Feeding America Bar Hunger 51589 4Synthetic Genomics Inc and ExxonMobil Research and Engineering Company Sign Exclusive Multi Year Agreement to Develop Next Generation Biofuels Using 13011 1Synthetic Genomics Inc and ExxonMobil Research and Engineering Company Sign Exclusive Multi Year Agreement to Develop Next Generation Biofuels Using 13011 2Synthetic Genomics Inc and ExxonMobil Research and Engineering Company Sign Exclusive Multi Year Agreement to Develop Next Generation Biofuels Using 13011 3
...t,s actions today changing federal policy on embry... American Policy Roundtable and Dr. Charles McGowe... issued the following statement: , , "The Preside...ht of years of progress in the realm of autologous... is frozen in failure all over the world while aut...
...ty -- an Interventional Radiology Treatment -- Det...SAN DIEGO, March 9 Osteoplasty -- a highly effect...ful effects of metastatic bone disease by injectin...s immediate and substantial pain relief, often pre...h the miraculous so-called "Lazarus effect," accor...
Other Medicine Technology:Metastatic Bone Disease Patients Can Walk in Lazarus' Footsteps 2Metastatic Bone Disease Patients Can Walk in Lazarus' Footsteps 3Metastatic Bone Disease Patients Can Walk in Lazarus' Footsteps 4Metastatic Bone Disease Patients Can Walk in Lazarus' Footsteps 5
(Date:11/8/2009).... 7 Tonight the House o...e for America Act, landmark health reform legislat...quality, affordable, stable and secure health care...ome of the insurance industry,s worst practices, w...ut the deficit by $104 billion over ten years. Gro...
(Date:11/8/2009)... Freeze-drying of biopharmaceuticals to be ava... facility. , Toronto, ON...dent and CEO of Therapure Biopharma Inc. today ann...mmercial scale pharmaceutical grade freeze dryer a...(lyophilization) available for contract manufactur...
(Date:11/8/2009).... 7 Today, the House of... Dahlkemper, Smith, Ellsworth and Lipinski amendme... (H.R. 3962). The amendment maintains the current ...and for benefits packages that include abortion. I...ve affordability credits and those who do not, can...
(Date:11/8/2009).... 7 USAction this eveni...r America Act, which will make health care more af...ccountable and increase access to health care for ..., "Teddy Roosevelt, FDR and Harry Truman would be...ey. "Today,s vote ranks among our country,s proude...
(Date:11/8/2009).... 8 The following was r...n Rescue Insurrecta Nex. ,, Mr. Terry and his ...ing to keep child-killing by abortion out of any h...: "This is a great first step to victory -- a touc... fighting ahead of us. Our rejoicing must be tempe...
Breaking Medicine News(10 mins):Health News:Democratic National Committee Chairman Tim Kaine Issues Statement Praising the House of Representative's Historic Vote to Pass Health Insurance Reform 2Health News:Democratic National Committee Chairman Tim Kaine Issues Statement Praising the House of Representative's Historic Vote to Pass Health Insurance Reform 3Health News:Therapure Biopharma Inc. Announces Delivery of its First Commercial-Scale Lyophilizer 2Health News:Family Research Council Praises Passage of Pro-life Amendment to Health Care Bill 2
...rifying case of blood transfusions probably turnin...4 more persons who had been given blood //transfus... of Jakob Creutz disease (vCJD). This was af...Lancet said blood transfusions appears to be an ef...
...ispensaries will do the rounds of rural areas as p...e needy and marginalized populations. // The... of Rs. 1.5 billion to states to set up mobile med...cheme for 2006-07. The document, tabled in ...
...-positive children were turned out of a school in ...en. // The MDLP School near Pampady district ...atened to withdraw their children from the school ...tes of Asha Kiran, an NGO formed under the aegis o...
...udy by specialists at the Johns Hopkins Children’s...ve inner-city children with chronic asthma //gets ...the disease. The findings, reported in Decemb... asthma attack strikes and to more complications a...
... City's Board of Health in a surprise move went ba... change the sex on their birth //certificates, wit... This proposal was keenly seconded by mental he...opposite' sexuality. Amid growing concerns ...
...ntless efforts of scientists to exploit prevailing...nd their value in impeding cognitive //decline in ...ypertensive agents, now the cynosure of scientists...ted with Alzheimer's. The research spearhead...
Other Medicine News:Health News:City Kids With Asthma Lose Out on Preventive Treatment 2
... foot and ankle or deformity and leg lengthening c...ternal Fixation components are designed to reduce ...lexity of intra-operative and post-operative frame...ractors and hinges eliminate the need to stock lar...
Gold Standard Interference Screw
...g hip surgery. The Stulberg Hip Positioner is use... hip and revision surgery. It is designed to attac...isting table adapters. The upright pads are made ... and are sealed with a washable coating. The coati...
...fixation system for small bone orthopedic osteotom...ion and a superior screw and plating system in one...ag screws used for the fixation of the hand and fo...ed to overdrill the proximal segment while the low...
Medicine Products: