Navigation Links
Anthrax Monoclonal Antibody Valortim Demonstrates Therapeutic,Effect in New Primate Model of Established Anthrax Infection

other agents in this challenging setting."

Preclinical studies suggest that Valortim has the potential to provide significant protection against anthrax infection when administered prophylactically (prior to the emergence of symptoms of anthrax infection) and also may increase survival when administered therapeutically (once symptoms become evident). In these studies, Valortim has been shown to protect both rabbits and monkeys against the lethal effects of anthrax infection when administered at the time of exposure, at doses as low as 1.0 mg/kg. When administered to rabbits after the development of symptoms, Valortim also improved survival as late as 48 hours post-exposure as compared to controls.

"We believe that there are distinct characteristics of Valortim that make it an ideal choice for military and civilian protection against an anthrax bioterrorist attack," commented David P. Wright, President and Chief Executive Officer of PharmAthene. "As our Phase I results have demonstrated, a single intramuscular dose of Valortim produces levels of antibodies in humans that correspond to protective levels in animal models and is well tolerated. Based on the impressive human safety and animal efficacy data collected to date, we believe that Valortim could meet the needs of the U.S. Government and could ultimately be selected for inclusion in the Strategic National Stockpile to provide protection to the American public."

About Valortim

Valortim (MDX-1303) is a fully human antibody designed to protect against anthrax infection, including inhalation anthrax, the most lethal form of illness in humans caused by the Bacillus anthracis bacterium. The investigational antibody is designed to target a protein component known as the anthrax protective antigen (PA) of the lethal toxin complex produced by the bacterium. The anthrax protective antigen is believed to initiate the onset of the illness by attaching to cells in the infected person, and then is
'"/>




Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Targanta Study Shows Oritavancin Treatment Effective in a Mouse Model of Anthrax
2. Cethromycin Shown Effective Against Anthrax in Study
3. Anthrax Monoclonal Antibody Valortim(tm) Demonstrates Therapeutic Effect in New Primate Model of Established Anthrax Infection
4. Phase I Results for ImClone Pipeline Anti-IGF-1R Monoclonal Antibody IMC-A12 Presented at ASCO
5. Vicals Vaxfectin Adjuvant With Needle-free Delivery Enhances DNA Vaccine Performance; Yields Antibody Responses Comparable to Electroporation Without Tolerability Issues
6. Positive Results Using Affitech-Identified Human Antibody That Blocks VEGF Binding to VEGF Receptor 2 in Preclinical Cancer Model Reported by Peregrine
7. Seattle Genetics Highlights Data on its Proprietary Antibody-Drug Conjugate Technology at AACR
8. Medarex Presents Preclinical Data Demonstrating Potent Anti-Tumor Activity of Anti-CD19 and Anti-CD70 Antibody-Drug Conjugates in Cancer Animal Models
9. Cell Genesys Reports GVAX Immunotherapy for Prostate Cancer Induces a Broad, Patient-Specific Antibody Response
10. Mymetics HIV Vaccine Achieves Research Breakthrough, Eliciting Protective Antibody Response in Mucosal Tissues of Non-Human Primate Model
11. La Jolla Pharmaceutical Provides Update on Interim Antibody Results From Riquent Lupus Phase 3 Trial
Post Your Comments:
(Date:10/12/2008)...tures thin struts designed for more uniform drug ...ass., and WASHINGTON, Oct. 12 /PRNewswire-FirstCal...today announced comprehensive data from,the TAXUS ...ctive,multi-center, single-arm, historically cont...(R) Paclitaxel-Eluting Stent System in a variety o...
(Date:10/10/2008)...phylaxis Treatment with Kogenate FS Reduces the,Ri... with No Pre-Existing,Joint Damage, BERKELEY, Cal...announced today that the U.S. Food and Drug Admini...th Kogenate(R) FS Antihemophilic Factor,(Recombina...nd the risk of,joint damage in patients aged 0-16 ...
(Date:10/9/2008)...gn to Spread Awareness and Bring Hope to Millions,...re-USNewswire/ -- 133 million children,across the ... as natural,disaster, civil war, and disease. SOS ...ld Orphan Week by calling attention to the needs o... Release, go to:, http://www.prnewswire.com/mnr/...
(Date:10/9/2008)... Science Institute, Navigenics, Affymetrix and,Mic...IEGO, Oct. 9 /- A consortium of healt...d forces in a first-of-its-kind,research study to ...esting,on people who choose to receive such screen...ng certain diseases., Sponsored by Scripps Transl...
Breaking Medicine Technology:Taxus Atlas Studies Reinforce Safety and Efficacy of Boston Scientific's Next-Generation Taxus Liberte Stent 2Taxus Atlas Studies Reinforce Safety and Efficacy of Boston Scientific's Next-Generation Taxus Liberte Stent 3Taxus Atlas Studies Reinforce Safety and Efficacy of Boston Scientific's Next-Generation Taxus Liberte Stent 4Taxus Atlas Studies Reinforce Safety and Efficacy of Boston Scientific's Next-Generation Taxus Liberte Stent 5Taxus Atlas Studies Reinforce Safety and Efficacy of Boston Scientific's Next-Generation Taxus Liberte Stent 6FDA Approves Bayer HealthCare's Kogenate(R) FS Treatment for Routine Prophylaxis in Children with Hemophilia A 2FDA Approves Bayer HealthCare's Kogenate(R) FS Treatment for Routine Prophylaxis in Children with Hemophilia A 3FDA Approves Bayer HealthCare's Kogenate(R) FS Treatment for Routine Prophylaxis in Children with Hemophilia A 4FDA Approves Bayer HealthCare's Kogenate(R) FS Treatment for Routine Prophylaxis in Children with Hemophilia A 5Photos: SOS Children's Villages Observes World Orphan Week, October 5-11, 2008 2Landmark Research Study is Launched to Assess Impact of Personal Genetic Testing 2Landmark Research Study is Launched to Assess Impact of Personal Genetic Testing 3Landmark Research Study is Launched to Assess Impact of Personal Genetic Testing 4Landmark Research Study is Launched to Assess Impact of Personal Genetic Testing 5Worlds only captive hairy nosed otter gets new home 3679 1Worlds only captive hairy nosed otter gets new home 3679 2Worlds only captive hairy nosed otter gets new home 3679 3 24100 million supercomputing program boosts Australian medical research capacity 22167 1 24100 million supercomputing program boosts Australian medical research capacity 22167 2Non Surgical Approach Can Treat Lung Cancers 22162 1Non Surgical Approach Can Treat Lung Cancers 22162 2Nuvelo to Present at Jefferies 2nd Annual Healthcare Conference 22157 1
...tients With Improved Potential,to Battle Their Dis...-FirstCall/ --,Arrowhead Research Corporation anno...aries, Insert Therapeutics Inc. and Calando,Pharma...erican,Association for Cancer Research (AACR) Annu... research findings on two,anticancer therapies cur...
...6, 2007 - Introgen Therapeutics,Inc. (NASDAQ:INGN...the weekend in Los Angeles, California at the Annu...Research., Abnormality of the p53 tumor suppressor...ar defects in cancer. ADVEXIN,s,mechanism of actio...nction and the detection of abnormal p53 is a logi...
Other Medicine Technology:Arrowhead Subsidiaries Insert & Calando Present Data on,Cyclosert Drug Delivery System at AACR Meeting 2Arrowhead Subsidiaries Insert & Calando Present Data on,Cyclosert Drug Delivery System at AACR Meeting 3Arrowhead Subsidiaries Insert & Calando Present Data on,Cyclosert Drug Delivery System at AACR Meeting 4Introgen Presents ADVEXIN Biomarker Data at Major Cancer Conference 2Introgen Presents ADVEXIN Biomarker Data at Major Cancer Conference 3Introgen Presents ADVEXIN Biomarker Data at Major Cancer Conference 4
(Date:10/10/2008)...Coach Holly Warlick Teams Up with Legal and Medica...Ever Cancer and Careers Seminar in,Knoxville, KNO...ion of National,Breast Cancer Awareness Month, Can...e joined forces with YWCA Knoxville, The Wellness ...e Holly Warlick, University of Tennessee,women,s b...
(Date:10/10/2008)... The Healthcare Technology Ev... , Exton, PA (PRWEB) Sept...ey Chapters of the national Healthcare Information...forces to bring regional health information techno... conference entitled The Healthcare Technology Evo...
(Date:10/10/2008)...ston, MABoston Medical Center (BMC) has received a...l Institute on Aging (NIA) to fund the Boston Clau...BMC,s Pepper Center is one of only 11 Pepper Cente... Americans Independence Center Program was establi...enator from Florida. During his five decades of pu...
(Date:10/10/2008)...olecular CT adds metabolic information from PET to...gnostic imaging for maximized workflow ...ICH, Germany, Oct. 10 /PRNewswire/ -- Siemens Heal...duces molecular CT, a new concept in,integrated im...d is a,practical solution for today,s shrinking he...
Breaking Medicine News(10 mins):Health News:Local Experts Help Women Living and Working with Cancer Even the Score 2Health News:Local Experts Help Women Living and Working with Cancer Even the Score 3Health News:Local Experts Help Women Living and Working with Cancer Even the Score 4Health News:HIMSS New Jersey and Delaware Valley Chapters Sponsor Regional Conference 2Health News:Boston Medical Center receives $5.8m grant 2Health News:Siemens Shapes the Future of Integrated Diagnostic Imaging 2Health News:Siemens Shapes the Future of Integrated Diagnostic Imaging 3Health News:Siemens Shapes the Future of Integrated Diagnostic Imaging 4
...ous for being extra conscious in front of the came...g her pins looking far from perfect . The usually...h above and below her knee, making her legs look h...irl was photographed while going for a shoot in ha...
...has sacked her kids' nanny for not turning up on t...hat the babysitter lied to her about visiting her ... the Algarve. The model had to take care of her s...did not turn up, and was delayed for Radio One sho...
... that kids ability to describe past incidences dev...m of researchers led by Yael Orbach at the Nationa...and the University of Cambridge. As part of the s...yzed forensic interviews of 250, 4 to 10-year-old ...
...ss has finally realised the true persona of her ex...e house and getting rid of his belongings, the sup...Slug. According to pals, Moss chose the nickname ...e junkie rockers habit of leaving a trail of nasty...
Other Medicine News:
...erence laboratory and a worldwide leader in innova...ers an extensive test menu of highly complex and u...logy. Owned by the University of Utah, ARUP Labora...on's university teaching hospitals and children's ...
...erence laboratory and a worldwide leader in innova...ers an extensive test menu of highly complex and u...logy. Owned by the University of Utah, ARUP Labora...on's university teaching hospitals and children's ...
...erence laboratory and a worldwide leader in innova...ers an extensive test menu of highly complex and u...logy. Owned by the University of Utah, ARUP Labora...on's university teaching hospitals and children's ...
...erence laboratory and a worldwide leader in innova...ers an extensive test menu of highly complex and u...logy. Owned by the University of Utah, ARUP Labora...on's university teaching hospitals and children's ...
Medicine Products: