Navigation Links
Anthrax Monoclonal Antibody Valortim(tm) Demonstrates Therapeutic,Effect in New Primate Model of Established Anthrax Infection

or saline (control) by intravenous injection. In the study, 50% of the Valortim-treated animals survived compared to none of the saline-treated animals.

"While post-exposure models of inhalation anthrax infection are relatively straight-forward, demonstrating efficacy in a therapeutic model for inhalation anthrax infection has proven somewhat challenging," remarked Valerie Riddle, M.D., Vice President and Medical Director for PharmAthene. "In most animal species in which anthrax has been studied, the disease course and time to death is markedly shorter than that seen in humans, making it challenging to evaluate the potential therapeutic efficacy of promising products. The model being developed by USAMRIID uses a rapidly detectable surrogate marker for the development of symptomatic disease to provide a consistent window in which to determine the therapeutic efficacy of Valortim in animals confirmed to have active disease. We believe this will be an important consideration for the licensure of novel anthrax therapeutics under the Food and Drug Administration's proposed Animal Rule."

Dr. Riddle continued, "This is a very encouraging survival result when one considers that these animals had bacteria multiplying in their blood and were poised to manifest severe symptoms and death at the time they were treated with Valortim. We plan to continue to collaborate with USAMRIID to further refine the model and determine the optimal therapeutic dose for Valortim."

"Previous studies in the rabbit animal model had suggested the capacity of Valortim to successfully treat symptomatic animals," noted Israel Lowy, M.D., Ph.D., Senior Director of Infectious Disease for Medarex. "The current studies in a non-human primate model, that may be more relevant to human disease, provide additional confirmation for those results. The methodological advances of the group at USAMRIID may help to better define the therapeutic potency of Valortim and other agents in this chall
'"/>




Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Targanta Study Shows Oritavancin Treatment Effective in a Mouse Model of Anthrax
2. Cethromycin Shown Effective Against Anthrax in Study
3. Anthrax Monoclonal Antibody Valortim Demonstrates Therapeutic Effect in New Primate Model of Established Anthrax Infection
4. Phase I Results for ImClone Pipeline Anti-IGF-1R Monoclonal Antibody IMC-A12 Presented at ASCO
5. Vicals Vaxfectin Adjuvant With Needle-free Delivery Enhances DNA Vaccine Performance; Yields Antibody Responses Comparable to Electroporation Without Tolerability Issues
6. Positive Results Using Affitech-Identified Human Antibody That Blocks VEGF Binding to VEGF Receptor 2 in Preclinical Cancer Model Reported by Peregrine
7. Seattle Genetics Highlights Data on its Proprietary Antibody-Drug Conjugate Technology at AACR
8. Medarex Presents Preclinical Data Demonstrating Potent Anti-Tumor Activity of Anti-CD19 and Anti-CD70 Antibody-Drug Conjugates in Cancer Animal Models
9. Cell Genesys Reports GVAX Immunotherapy for Prostate Cancer Induces a Broad, Patient-Specific Antibody Response
10. Mymetics HIV Vaccine Achieves Research Breakthrough, Eliciting Protective Antibody Response in Mucosal Tissues of Non-Human Primate Model
11. La Jolla Pharmaceutical Provides Update on Interim Antibody Results From Riquent Lupus Phase 3 Trial
Post Your Comments:
(Date:8/28/2014)... Aug. 28, 2014  Decision Resources Group finds that the ... around $7.7 billion by 2023 in the United ... Germany , Italy , ... and Japan . The biosimilar erosion of ... balanced out by the launch of Eli Lilly,s Cyramza, Taiho ...
(Date:8/28/2014)... 2014 Levi & Korsinsky announces that a ... States District Court for the District of ... Galectin Therapeutics Inc. ("Galectin" or the "Company") (NasdaqCM: GALT) ... For more information, click here: http://zlk.9nl.com/galectin-therapeutics-galt ... Class Period the Company violated federal securities laws by ...
(Date:8/28/2014)... Nonin Medical, Inc., the inventor of finger pulse oximetry ... that the Food and Drug Administration (FDA) has cleared ... use in the United States . ... or kiosk through a USB connector and measures oxygen ... The Model 3231 received EU certification last year. ...
Breaking Medicine Technology:The Colorectal Cancer Market Will Remain Steady at $7.7 Billion by 2023, With Biosimilar Erosion Of Key Agents Being Balanced Out By the Launch Of Premium-Priced Therapies 2SHAREHOLDER ALERT: Levi & Korsinsky, LLP Reminds Investors of Class Action Against Galectin Therapeutics Inc. and Its Board of Directors and a Lead Plaintiff Deadline of September 29, 2014 -- GALT 2Nonin Medical Announces FDA Clearance of Nonin Model 3231 USB Pulse Oximeter 2
... 15, 2012 Senior representatives from leading pharmaceutical ... Novartis MIT will meet at the Pharma Qbd Forum in ... to share their expert knowledge on how Quality by Design ... the main points of discussion will be the findings of ...
... Feb. 14, 2012  At a meeting held today, the Directors ... per share. The dividend is payable on March 15, 2012 ... About Sigma-Aldrich :  Sigma-Aldrich ... High Technology company whose biochemical, organic ...
Cached Medicine Technology:Understand the Lessons Learned from the FDA QbD Pilot Programme - Case Study Merck Serono 2
(Date:8/28/2014)... Toronto, Ontario (PRWEB) August 28, 2014 ... and supply company in North America, today announced the ... that makes doing business with Canadian Linen even ... tool allows customers to access account information online and ... new customer portal include the ability to:, ...
(Date:8/28/2014)... Parker Waichman LLP, a national personal ... to ensure that the heroes of 9/11 are never ... WTC victims who developed 9/11-related cancer was reaffirmed by ... (GAO). According to a statement issued by 9/11 ... entitled “World Trade Center Health Program: Approach Used to ...
(Date:8/28/2014)... Watertown, MA (PRWEB) August 28, 2014 ... , is delighted to present its new Kids’ Share, which ... Share will encourage kids (and their parents) to get into ... their very own vegetable share. Each week the Kids’ Share ... fabulous veggies, shares will include activities for kids, recipes from ...
(Date:8/28/2014)... 2014 Clarity PSO , an ... as a federal Patient Safety Organization (PSO) for another ... Healthcare Research and Quality (AHRQ). Clarity PSO will continue ... services following the true intentions of the Patient Safety ... are proud and eager to continue our journey as ...
(Date:8/28/2014)... 2014 (HealthDay News) -- Having greater amounts of yellow ... see distant objects in hazy conditions, a new study ... researchers simulated hazy conditions in order to test the ... pigment (also called macular pigment) in their eyes. ... which represents accumulations of the nutrients lutein and zeaxanthin, ...
Breaking Medicine News(10 mins):Health News:Canadian Linen and Uniform Service Launches New Customer Portal 2Health News:Canadian Linen and Uniform Service Launches New Customer Portal 3Health News:GAO Report Reaffirms Decision to Add Cancers to List of Illnesses Covered under the Zadroga Act, Parker Waichman LLP Comments 2Health News:GAO Report Reaffirms Decision to Add Cancers to List of Illnesses Covered under the Zadroga Act, Parker Waichman LLP Comments 3Health News:Kids Don't Have to Share Their Vegetables, Thanks to Siena Farms, ChopChop Magazine & Chef Ana Sortun 2Health News:Kids Don't Have to Share Their Vegetables, Thanks to Siena Farms, ChopChop Magazine & Chef Ana Sortun 3Health News:Kids Don't Have to Share Their Vegetables, Thanks to Siena Farms, ChopChop Magazine & Chef Ana Sortun 4Health News:Clarity PSO Re-lists as a Patient Safety Organization and Continues to Advance Patient Safety 2Health News:Clarity PSO Re-lists as a Patient Safety Organization and Continues to Advance Patient Safety 3Health News:Eye Pigment May Help Vision in Hazy Conditions 2
... 18 One year ago today, the,American people ... and outpatient facilities treating wounded soldiers returning,from Iraq ... those,reports, John McCain saw an opportunity to bolster ... blamed the scandal on former,Secretary of Defense Don ...
... Rep. Jason Altmire,(D-PA) will experience the vital and expanding ... of the clinical laboratory facilities,at Magee-Womens Hospital Tuesday, Feb. ... the 5:30 P.M. tour for,Rep. Altmire, who will view ... "Magee-Womens Hospital,s ongoing leadership in improving health care,for ...
... ALAMOS, N.M., Feb. 18 Meat & Livestock ... techniques for,high-speed CT scans of livestock carcasses. Using ... will begin Phase 1 of a,multi-year, 6 phase ... production CT applications include the potential to scan ...
... be,prepared and take action., That,s the advice ... tragedies like the one recently at Northern Illinois ... of K-State,s College of,Human Ecology and associate professor ... Research, Education and Consultation at K-State, or TRECK,Team., ...
... Spanish . , ANN ARBOR, Mich. People taking ... their symptoms during the first few months, but lagging behind ... research from the University of Michigan Health System. , That ... hopelessness even while their condition is improving, which could lead ...
... Feb. 18 Darwin,Professional Underwriters, Inc. (Darwin), ... its lawyers professional liability policy. Limits of ... from one to one hundred attorneys. All,areas ... maintains a particular,focus on plaintiff,s personal injury ...
Cached Medicine News:Health News:Walter Reed Anniversary Exposes More McCain Double Talk 2Health News:Walter Reed Anniversary Exposes More McCain Double Talk 3Health News:Congressman Altmire Tours Women's Health Clinical Laboratory; Learns Vital Role in Patient Care 2Health News:IMTEC to Become Technology Solutions Provider for Meat & Livestock Australia 2Health News:K-State Trauma Researcher Says Being Prepared, Taking Action Are Vital in Preventing Tragedies Like the One at NIU 2Health News:As depression symptoms improve with antidepressants, hopelessness can linger 2Health News:Darwin Introduces Enhancements to its Lawyers Professional Liability Insurance Policy Including Privacy Wrongful Acts and More 2Health News:Darwin Introduces Enhancements to its Lawyers Professional Liability Insurance Policy Including Privacy Wrongful Acts and More 3
... mechanism for speed, stability and durability. ... display modes, multiple units of measure, ... auto print, and GLP/GMP/ISO output including ... clock. Built-in, motor-driven internal calibration ...
TOPLOAD 3200/0.01G, BL3200H. Touch-key external calibration only. Requires calibration weights (either 2000g or 3000g). 120/240V A/C adapter, Lock-down Ring, In-use Protective Cover....
... Portable - Battery Powered (6 size AA ... conversion (g, ct, oz, ozt, GN, dwt, ... Counting and Percent Measure functions, Auto Print. ... Optional AC adapter may be ordered for ...
... BX620S. Digital stability control, analog display ... counting and percent measure functions, auto ... and time data from built-in clock. ... (selectable from 200g to 600g). Built-in ...
Medicine Products: