Navigation Links
Anacor Identifies a Novel Mechanism for Its Lead Anti-Fungal Drug,,AN2690; Findings Published in Science

e European Molecular Biology Laboratory (EMBL) in Grenoble, France, led by Stephen Cusack, Ph.D., then determined how the drug worked at the molecular level.

By examining fungal strains resistant to the drug, scientists determined that the drug blocks protein synthesis by inhibiting a protein called leucyl-tRNA synthetase, or LeuRS. LeuRS plays a key role in translating the genetic code in both fungus and bacteria, and blocking its action keeps those organisms from growing, effectively stopping the infection. Researchers found that replacing the boron atom in AN2690 with a carbon atom inactivated the drug, underscoring the importance of the boron chemistry.

While the anti-fungal effect of the LeuRS protein inhibition by boron-containing compounds has been established by the clinical results seen for AN2690, other proteins from the same family, known as aminoacyl-tRNA synthetases, are well-validated targets for antibiotic drug development.

"Now that we know how AN2690 works, the same approach could be adapted to target other aminoacyl-tRNA synthetases with editing sites, which are also excellent targets for anti-microbial drugs," said Cusack, whose group performed the X-ray crystallography which revealed how AN2690 binds to LeuRS.

Anacor is now leveraging that knowledge to create new boron-containing drugs designed to target systemic bacterial infections.

"Drug-resistant bacteria are a large and growing problem in the hospital and in the community, which makes the discovery of novel antibiotics a public health necessity," said David Perry, Anacor's chief executive officer. "We believe that our approach may hold great promise in the development of these needed therapies."

Boron is a naturally occurring element found in the soil and in water supplies. It is an essential micronutrient for plants, and the chemical is commonly present in its elemental form in the human bloodstream. Despite the ubiquity of the element, little work
'"/>




Page: 1 2 3

Related medicine technology :

1. Anacor Clinical Study of AN2728, a Novel Anti-Inflammatory Compound, Shows Efficacy in Psoriasis
2. CV Therapeutics Identifies Potential Anti-Diabetic Mechanism of Action for Ranexa
3. ARRIVE Registry Analysis Identifies Predictors of Stent Thrombosis in Real-World Use of Drug-Eluting Stents
4. Pharmacyclics Identifies Functional Biomarkers for its Novel HDAC Inhibitor and Demonstrates Preclinical Anti-Tumor Activity with Brutons Tyrosine Kinase Inhibitors
5. NIDA Study Identifies Genes That Might Help Some People Abstain from Smoking
6. Rigel Ubiquitin Ligase Program Identifies Molecules With Anti-HIV Activity
7. Study in Cell by Magen BioSciences Co-Founder David E. Fisher Identifies New Roles in Skin Cancer Prevention for Key Tumor Suppressor Protein
8. Tranzyme Pharma Presents Initial Phase IIa Data for its Novel Ghrelin Agonist, TZP-101, in Patients with Diabetic Gastroparesis
9. Novelos Therapeutics Announces Encouraging Results in Ongoing Phase 2 Ovarian Cancer Trial at Dana-Farber/Partners Cancer Care
10. Prolexys Pharmaceuticals and Columbia University Researchers Publish Study on Anti-Tumor Properties of a Selective Small Molecule Anti-Tumor Agent With Novel Mechanism of Action
11. Algeta Demonstrates Targeted Cancer-killing Potential of Novel Alpha Particle Linked Antibodies in Leading Medical Journal Blood
Post Your Comments:
(Date:9/19/2014)... 19, 2014 The Parenteral Drug Association (PDA) ... post-approval changes protocols. The new initiative ... expressed by industry participants and regulatory authority representatives at ... in Washington, DC . Representatives of ... for the workshop. Attendees indicated openness to engaging regulators ...
(Date:9/19/2014)... DALLAS , Sept. 19, 2014 ... Market Outlook to 2020″, provides key ... General Surgery devices market. The report ... dollars, and volume (in units) within ... Cystoscopes, Colonoscopes, Sigmoidoscopes, Esophagoscopes & Gastroscopes, ...
(Date:9/19/2014)...  The board of directors of AbbVie Inc. (NYSE: ... of $0.42 per share.  The cash ... record at the close of business on Oct. 15, ... research-based biopharmaceutical company formed in 2013 following separation from ... dedicated people and unique approach to innovation to develop ...
Breaking Medicine Technology:PDA Launches Effort to Harmonize Global Post-Approval Changes Protocols 2United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 2United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 3United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 4United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 5
... BRUNSWICK, N.J., Dec. 15, 2010 Johnson & Johnson ... Gorsky, currently Worldwide Chairman, Medical Devices & Diagnostics (MD&D) ... appointed Vice Chairmen of the Executive Committee and join ... Executive Officer, in an expanded Office of the Chairman. ...
... Control Risks , one of the world,s leading ... its annual review and forecast of business risk for the ... and security risk in 173 countries. 2011 will ... both politically and economically, as the world,s emerging economies use ...
Cached Medicine Technology:Johnson & Johnson Announces Executive Appointments: Alex Gorsky, Vice Chairman, Executive Committee Sheri McCoy, Vice Chairman, Executive Committee 2Johnson & Johnson Announces Executive Appointments: Alex Gorsky, Vice Chairman, Executive Committee Sheri McCoy, Vice Chairman, Executive Committee 3Control Risks Forecasts New Reality for Business in 2011 Brought by Emerging Markets, Legislation 2
(Date:9/20/2014)... RBSEO Services, which has occupied a ... announced it provides an affordable website SEO (Search Engine ... announcement would benefit those new and old businesses struggling ... afford to pay a big amount for their website ... websites in top search results for their business keywords ...
(Date:9/20/2014)... 20, 2014 The Arizona Advanced ... is celebrating National Manufacturing Day by opening its doors ... processing and additive manufacturing labs will be offered between ... at MCC’s Southern and Dobson campus (1833 W. Southern ... Lot D. , The AzAMI at MCC was established ...
(Date:9/20/2014)... “Motherhood is a wonderful gift and a huge responsibility,” ... article , “We know that you want to care for ... want to do as well.” , The article explains to ... their Family Physicians who practice obstetrics while pregnant, during delivery, ... To learn more about Community Health Center of Snohomish County ...
(Date:9/20/2014)... Miami, FL (PRWEB) September 20, 2014 ... to get the balanced and active play they need. ... Family Branches Center - Lakeview Campus was transformed into ... the help of 150+ volunteers from Branches (@BranchesFL), ESPN ... (@kaboom). , KaBOOM! believes a playground is more ...
(Date:9/19/2014)... Consistent premium price increases have ... Insurance industry in recent years; however, costs have ... margins. From 2009 to 2014, industry revenue is ... for routine eye exams and other procedures, as ... and refractive surgery. According to IBISWorld Industry Analyst ...
Breaking Medicine News(10 mins):Health News:RBSEO Services Announces Affordable Website SEO Service at Only $175 2Health News:National Manufacturing Day Open House at Mesa Community College Oct. 3 2Health News:Newest Article from Community Health Center of Snohomish County Highlights The Importance of Proper Health Care for Expectant Mothers 2Health News:Volunteers Improve Miami Kids’ Lives and Futures with Play 2Health News:Volunteers Improve Miami Kids’ Lives and Futures with Play 3Health News:Volunteers Improve Miami Kids’ Lives and Futures with Play 4Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 4
... dysfunction due to obesity may be reversible with weight ... results will be presented Saturday at The Endocrine Society,s ... have a high prevalence of hypotestosteronenemia, or low testosterone, ... MD, PhD, a professor at the University of Louvain ...
... 2011 - Additional radiation treatment improves disease free survival ... early breast cancer who have had breast conserving surgery ... results will be presented Monday, June 6 at the ... "These results are potentially practice-changing," said Dr. ...
... study examining disparities in physical fitness levels between ... community health centers (CHC) and those who are ... producing stunning results. NiCole Keith, associate professor ... University-Purdue University Indianapolis, said she expected the study ...
... Reporter , FRIDAY, June 3 (HealthDay News) -- Early ... the cancer,s return drop by 32 percent when the ... for three years after surgery, Austrian researchers report. ... to develop osteoporosis, so they are usually given a ...
... , FRIDAY, June 3 (HealthDay News) -- College ... memory, researchers have found. A concussion is a ... changes, vomiting, changes in vision and hearing, as well ... effect of concussion on brain functioning in student-athletes," study ...
... News) -- Providing children with more toys to play with ... The new study also found that having more active toys ... particularly girls. In the study, led by ... New York, researchers offered three different quantities of toys to ...
Cached Medicine News:Health News:Breast cancer surgery patients benefit from adding radiation therapy 2Health News:Indiana U. study points to health disparities in physical fitness 2Health News:Bone Drug Reduces Odds for Breast Cancer's Return: Study 2Health News:Bone Drug Reduces Odds for Breast Cancer's Return: Study 3Health News:Concussions Tied to Verbal Memory Loss in Young Athletes 2Health News:Having More Toys May Boost Exercise Levels in Kids 2
30 Degree Angle Shaft with 1.0mm 90 Degree Angle Tip; in stainless steel....
0.5mm "K" hook. Rounded knurled handle; shaft angled 11mm from tip; overall length 120mm, in Titanium....
Lightly Curved-Blunt Tips Rounded Blades; 1mm Eye in Blades; 27mm from mid screw to tip. Matte finish; Stainless Steel, overall length 120mm...
... Catheter is indicated for balloon ... of a coronary artery or ... purpose of improving myocardial perfusion. ... also designed to provide distal ...
Medicine Products: