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An Investigational Study Released at ADA Showed that Initial,Combination Therapy with Januvia (sitagliptin) and Metformin Led to,Improvement in Markers of Beta Cell Function in Patients with Type,2 Diabetes

clinical illness should be evaluated promptly for evidence of ketoacidosis or lactic acidosis. The reported incidence of lactic acidosis in patients receiving metformin hydrochloride is very low (approximately 0.03 cases/1000 patient-years, with approximately 0.015 fatal cases/1000 patient-years). When lactic acidosis occurs, it is fatal in approximately 50 percent of cases.

Expanding clinical development program for sitagliptin family

Merck's clinical development program for sitagliptin is robust and continues to expand with 47 studies completed or under way, and nine more studies set to begin this year. There have been more than 7,600 patients in the Company's clinical studies with about 4,700 of these patients, being treated with sitagliptin. Additionally, about 1,900 patients have been treated with sitagliptin for more than a year.

Merck's Commitment to Type 2 Diabetes

Journey for Control(TM) is Merck's comprehensive educational initiative designed to enlighten, inspire, and empower patients with diabetes by helping them make the necessary lifestyle modifications that lead to improved self-management. The program includes resources for physicians, diabetes educators, patients and health plans; all created with a focus on improving diabetes education. The Merck Journey for Control Program is proud to sponsor the U.S. Diabetes Conversation Maps, an interactive program that combines visual learning techniques and active dialogue between patients and healthcare professional to engage patients in sustainable behavior change.

The U.S. Diabetes Conversation Maps will provide physicians and diabetes educators with a uniquely powerful way to engage patients in conversations to help support behavior changes that can make a critical difference in treatment outcomes. Content for the U.S. Diabetes Conversation Map was developed and reviewed by the ADA and the program was launched in June at the ADA 67th Annual Scientific Sessions in Chicago
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