Navigation Links
An Investigational Study Released at ADA Showed that Initial,Combination Therapy with Januvia (sitagliptin) and Metformin Led to,Improvement in Markers of Beta Cell Function in Patients with Type,2 Diabetes

rately, increased overall, post-meal, active concentrations of GLP-1 levels by 1.95- and 1.76-fold, respectively (pless than0.001), compared with placebo. When administered together, JANUVIA and metformin increased active concentrations of GLP-1 by 4.12-fold (pless than0.001) compared with placebo. In contrast to active GLP-1 levels that were increased by both drugs, the levels of total GLP-1 (which includes both active and inactive GLP-1) were increased by metformin only and not by JANUVIA. These observations are consistent with the effect of JANUVIA to raise active GLP-1 levels by reducing the clearance, but suggest that metformin acts in a different manner to increase active GLP-1 levels. This study provides evidence that the two drugs may have complementary effects on GLP-1.

"This is the first study in humans that showed that metformin increases the concentration of the incretin hormone, GLP-1; thus increasing the total GLP-1 available. When used together with JANUVIA, a DPP-4 inhibitor that blocks the degradation of GLP-1 by inhibiting its breakdown, there was an increase in GLP-1 levels greater than what either agent provided alone," said Nir Barzilai, M.D., professor of Medicine and Molecular Genetics and director of the Institute for Aging Research, Albert Einstein College of Medicine. "It appears as though metformin allows for more total GLP-1 to be available, and JANUVIA helps GLP-1 to remain active thus acting in a complementary way."

GLP-1 plays an important role in regulating the body's blood sugar levels. When food is consumed, GLP-1 is released by the gastrointestinal tract to stimulate the pancreatic beta cells to secrete insulin, a hormone that helps the body to use glucose for energy. GLP-1 also suppresses the release of glucagon from the pancreatic alpha cells, which, in turn, tells the liver to reduce its production of sugar.

Dosing of JANUVIA

The recommended dose of JANUVIA is 100 mg once daily, with or without food,
'"/>




Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32

Related medicine technology :

1. Phase 3 Results for Dabigatran Etexilate, an Investigational Oral Anticoagulant, Presented Today at the XXIst Congress of the International Society on Thrombosis and Haemostasis
2. Late Breaking Data Released at ADA Showed that the Investigational Use of Januvia and Metformin as Initial Combination Therapy Provided Significant Glucose Lowering Efficacy over 54 Weeks in Patients with Type 2 Diabetes
3. Investigational Study Demonstrated a Re-Establishment of Clinical Improvement with Orencia (Abatacept) in Children with Juvenile Idiopathic Arthritis upon Re-Introduction of Therapy
4. Mercks Investigational Migraine Treatment MK-0974 Significantly Improved Migraine Pain on Several Efficacy Measures in a Phase II Study
5. Data Demonstrated Metastatic Melanoma Response to Investigational Immunotherapy Ipilimumab
6. Investigational Drug Cediranib (AZD2171) Shows Promise in Patients With Recurrent Glioblastoma (GBM)
7. Additional New Data from Satraplatin SPARC Phase 3 Investigational Trial Presented at ASCO Annual Meeting
8. Additional New Data from Satraplatin SPARC Phase 3 Investigational Trial Presented at ASCO Annual Meeting
9. Investigational Cancer Drug Pertuzumab Shows Promising Results in Advanced Breast Cancer When Combined with Herceptin
10. Shire Announces Positive Results of Studies With Guanfacine Extended Release, An Investigational Nonstimulant Medication Filed for the Treatment of ADHD in Children and Adolescents
11. Investigational Study Evaluates the Effectiveness of Aripiprazole in Adolescents With Schizophrenia
Post Your Comments:
(Date:7/30/2014)... PARIS , July 30, 2014 /PRNewswire/ ... Sanofi (EURONEXT: SAN and NYSE: SNY ) ... of alirocumab in people with hypercholesterolemia met their primary ... in low-density lipoprotein cholesterol (LDL-C) at 24 weeks compared ... monoclonal antibody targeting PCSK9 (proprotein convertase subtilisin/kexin type 9). ...
(Date:7/30/2014)... 2014  DigiPath, Inc. (OTCBB and OTCQB: DIGP), a ... cannabis testing and education markets, announced today that has ... not previously disclosed or, to its knowledge, any other ... "We have noticed unusual price and volume ... days," said Steve Barbee , CEO of DigiPath. ...
(Date:7/30/2014)... Coordinators, Inc. (PCI) is pleased to announce it has ... Limited (Penn Pharma). Penn Pharma is headquartered in Tredegar, ... Kingdom and operates regional offices in ... Tokyo , Japan. Penn Pharma offers both drug development ... manufacturing, as well as Clinical Packaging, Labeling, and global ...
Breaking Medicine Technology:Regeneron and Sanofi Report Positive Top-Line Results from Nine Phase 3 Trials of Alirocumab in People with Hypercholesterolemia 2Regeneron and Sanofi Report Positive Top-Line Results from Nine Phase 3 Trials of Alirocumab in People with Hypercholesterolemia 3Regeneron and Sanofi Report Positive Top-Line Results from Nine Phase 3 Trials of Alirocumab in People with Hypercholesterolemia 4Regeneron and Sanofi Report Positive Top-Line Results from Nine Phase 3 Trials of Alirocumab in People with Hypercholesterolemia 5Regeneron and Sanofi Report Positive Top-Line Results from Nine Phase 3 Trials of Alirocumab in People with Hypercholesterolemia 6Regeneron and Sanofi Report Positive Top-Line Results from Nine Phase 3 Trials of Alirocumab in People with Hypercholesterolemia 7Regeneron and Sanofi Report Positive Top-Line Results from Nine Phase 3 Trials of Alirocumab in People with Hypercholesterolemia 8DigiPath No New Corporate Developments 2PCI Announces Definitive Agreement to Acquire Penn Pharma 2PCI Announces Definitive Agreement to Acquire Penn Pharma 3PCI Announces Definitive Agreement to Acquire Penn Pharma 4PCI Announces Definitive Agreement to Acquire Penn Pharma 5
... FDA approved Makena (hydroxyprogesterone caproate) in February 2011 ... births in women who have had at least one ... approved, a version of the active ingredient of Makena ... drug from a pharmacist who compounded the drug.  In ...
... N.J., Nov. 8, 2011 Covance Inc. (NYSE: ... Credit Suisse Healthcare Conference on Thursday, November 10, 2011 at ... the presentation at www.covance.com .  In order to register ... early. Covance, with headquarters in Princeton, New Jersey, ...
Cached Medicine Technology:FDA Statement on Makena 2Covance to Present at Credit Suisse 2011 Healthcare Conference 2
(Date:7/30/2014)... (HealthDay News) -- Clues to whether a person is at ... a new study suggests. Chemical changes to a gene ... spur suicidal thoughts and behaviors, the study,s authors explained. Spotting ... to a patient,s risk for suicide, they said. "Suicide ... been stymied in our prevention efforts because we have no ...
(Date:7/30/2014)... digital pathology market was valued at an estimated $250.2 million ... of 11.8%, to reach an estimated $437 million by 2018. ... expected to continue to rise in the coming years as ... pathologists to be efficient and this leads to improved quality ... was valued at $128.9 million and accounted for the largest ...
(Date:7/30/2014)... news release is available in French . ... led by Claude Gronfier (Inserm Unit 846: Stem Cell ... a study under real conditions on the body clocks ... The researchers have shown that a particular kind of ... rhythms are correctly synchronised despite the absence of sunlight. ...
(Date:7/30/2014)... with depression as preschoolers are likely to suffer from ... shows. , Depressed preschoolers were 2.5 times more likely ... school than kids who were not depressed at very ... of Medicine in St. Louis. , Their study is ... Journal of Psychiatry . , "It,s the same old ...
(Date:7/30/2014)... have found that a support program administered entirely ... symptoms in informal caregivers, such as family or ... published online in advance of print in the ... caring for people with Alzheimer,s disease or other ... deal of pressure," said principal investigator Geoffrey Tremont, ...
Breaking Medicine News(10 mins):Health News:Could a Blood Test Predict Suicide Risk? 2Health News:Could a Blood Test Predict Suicide Risk? 3Health News:Global Digital Pathology Market To See 11.8% CAGR to 2018 Says a New Research Report Available at ReportsnReports.com 2Health News:Global Digital Pathology Market To See 11.8% CAGR to 2018 Says a New Research Report Available at ReportsnReports.com 3Health News:Global Digital Pathology Market To See 11.8% CAGR to 2018 Says a New Research Report Available at ReportsnReports.com 4Health News:Global Digital Pathology Market To See 11.8% CAGR to 2018 Says a New Research Report Available at ReportsnReports.com 5Health News:Dimly lit working environments: Correcting your body clock is possible! 2Health News:Dimly lit working environments: Correcting your body clock is possible! 3Health News:Dimly lit working environments: Correcting your body clock is possible! 4Health News:Many depressed preschoolers still suffer in later school years 2Health News:Many depressed preschoolers still suffer in later school years 3Health News:Study: Telephone support program beneficial for caregivers of those with dementia 2
... E-coli 0157, which is a stark eye-opener that adequate measures ... fatal food poisoning infection//. Three fresh cases, not connected to ... in South Lanarkshire, were confirmed yesterday. , ,A warning ... its dangers. But this by no means is to instigate ...
... at an IVF clinic almost destroyed their lives. In an interview ... they had to undergo when they came to know that the ... ,The couple had twins and it was quite obvious that ... by Leeds NHS Trust. "I was physically sick. The thought that ...
... says, as smoking, eating poor diets like too little fish, fruit and vegetables puts human ... ... ,Insufficient consumption of ... European Food Safety Authority, Netherland says. ,Dutch National Institute for Public Health and ...
... of exercise results from an increase in a protein ... and cause cell death. ,A study reports ... inhibits the action of another protein called insulin-like growth ... due to which the result appears. ,In ...
... people have died of heat and hundreds of people suffering ... Punjab province// , Daily Times newspaper reported Monday. ,At ... said. ,Most of the deaths were reported from ... in Multan and 48 degrees in Dera Ghazi Khan and ...
... Gurgaon (Haryana). When millions of disabled people are still dreaming ... has etched out// her own identity as a voice and ... the blind community faces a lot of barriers ranging from ... to be different can help them to overcome all of ...
Cached Medicine News:Health News:Unhealthy Diet Reduces Life Expectancy 2Health News:'Being Disabled Is Not a Barrier to Success' 2
The Guidant Fineline II Sterox Atrial J is a steroid-eluting pacing lead designed for permanent implantation for either atrial or ventricular applications....
The Guidant Fineline II Sterox is a steroid-eluting pacing lead designed for permanent implantation for either atrial or ventricular applications....
The Guidant Fineline II Sterox is a steroid-eluting pacing lead designed for permanent implantation for either atrial or ventricular applications....
Steroid eluting pacemaker leads...
Medicine Products: