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An Investigational Study Released at ADA Showed that Initial,Combination Therapy with Januvia (sitagliptin) and Metformin Led to,Improvement in Markers of Beta Cell Function in Patients with Type,2 Diabetes

N = 453 N = 224 ----------------------------------------------------------- --------- Baseline (mean) 8.0 8.0 ----------------------------------------------------------- --------- Change from baseline (adjusted mean++) -0.7 -0.0 ----------------------------------------------------------- --------- Difference from placebo + metformin (adjusted -0.7ss. mean++) (95% CI) (-0.8, -0.5) ----------------------------------------------------------- --------- Patients (%) achieving A1C less than7% 213 (47%) 41 (18%) ----------------------------------------------------------- --------- FPG (mg/dL) N = 454 N = 226 ----------------------------------------------------------- --------- Baseline (mean) 170 174 ----------------------------------------------------------- --------- Change from baseline (adjusted mean++) -17 9 ----------------------------------------------------------- --------- Difference from placebo + metformin (adjusted -25ss. mean++) (95% CI) (-31, -20) ----------------------------------------------------------- --------- 2-hour PPG (mg/dL) N = 387 N = 182 ----------------------------------------------------------- --------- Baseline (mean) 275 272 ----------------------------------------------------------- --------- Change from baseline (adjusted mean++) -62 -11 ----------------------------------------------------------- --------- Difference from placebo + metformin (adjusted -51ss. mean++) (95% CI) (-61, -41) ----------------
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