( dy compared to asmall reduction in p...)An Investigational Study Released at ADA Showed that Initial,Combination Therapy with Januvia (sitagliptin) and Metformin Led to,Improvement in Markers of Beta Cell Function in Patients with Type,2 Diabetes,Health

dy, compared to a small reduction in patients given placebo. Table 2 Glycemic Parameters in 18- and 24-Week Placebo-Controlled Studies of JANUVIA in Patients with Type 2 Diabetes+ ---------------------------------------------------------------------- 18-Week Study 24-Week Study ----------------- ----------------- JANUVIA Placebo JANUVIA Placebo 100 mg 100 mg ------------------------------------------- -------- -------- -------- A1C (%) N = 193 N = 103 N = 229 N = 244 ------------------------------------------- -------- -------- -------- Baseline (mean) 8.0 8.1 8.0 8.0 ------------------------------------------- -------- -------- -------- Change from baseline (adjusted mean++) -0.5 0.1 -0.6 0.2 ------------------------------------------- -------- -------- -------- Difference from placebo (adjusted -0.6ss. -0.8ss. mean++) (95% CI) (-0.8, (-1.0, -0.4) -0.6) ------------------------------------------- -------- -------- -------- Patients (%) achieving A1C less than7% 69 (36%) 16 (16%) 93 (41%) 41 (17%) ------------------------------------------- -------- -------- -------- FPG (mg/dL) N = 201 N = 107 N = 234 N = 247 ------------------------------------------- -------- -------- -------- Baseline (mean) 180 184 170 176 ------------------------------------------- -------- -------- -------- Change from baseline (adjusted mean++) -13 7 -12 5 ------------------------------------------- -------- -------
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