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An Investigational Study Released at ADA Showed that Initial,Combination Therapy with Januvia (sitagliptin) and Metformin Led to,Improvement in Markers of Beta Cell Function in Patients with Type,2 Diabetes

dy, compared to a small reduction in patients given placebo. Table 2 Glycemic Parameters in 18- and 24-Week Placebo-Controlled Studies of JANUVIA in Patients with Type 2 Diabetes+ ---------------------------------------------------------------------- 18-Week Study 24-Week Study ----------------- ----------------- JANUVIA Placebo JANUVIA Placebo 100 mg 100 mg ------------------------------------------- -------- -------- -------- A1C (%) N = 193 N = 103 N = 229 N = 244 ------------------------------------------- -------- -------- -------- Baseline (mean) 8.0 8.1 8.0 8.0 ------------------------------------------- -------- -------- -------- Change from baseline (adjusted mean++) -0.5 0.1 -0.6 0.2 ------------------------------------------- -------- -------- -------- Difference from placebo (adjusted -0.6ss. -0.8ss. mean++) (95% CI) (-0.8, (-1.0, -0.4) -0.6) ------------------------------------------- -------- -------- -------- Patients (%) achieving A1C less than7% 69 (36%) 16 (16%) 93 (41%) 41 (17%) ------------------------------------------- -------- -------- -------- FPG (mg/dL) N = 201 N = 107 N = 234 N = 247 ------------------------------------------- -------- -------- -------- Baseline (mean) 180 184 170 176 ------------------------------------------- -------- -------- -------- Change from baseline (adjusted mean++) -13 7 -12 5 ------------------------------------------- -------- -------
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