Navigation Links
An Investigational Study Released at ADA Showed that Initial,Combination Therapy with Januvia (sitagliptin) and Metformin Led to,Improvement in Markers of Beta Cell Function in Patients with Type,2 Diabetes

ary creatinine clearance measurements or estimated from serum creatinine based on the Cockcroft-Gault formula: CrCl = (140 - age (years)) x weight (kg) {x 0.85 for female patients} --------------------------------- (72 x serum creatinine (mg/dL)) Compared to normal healthy control subjects, an approximate 1.1- to 1.6-fold increase in plasma AUC of sitagliptin was observed in patients with mild renal insufficiency. Because increases of this magnitude are not clinically relevant, dosage adjustment in patients with mild renal insufficiency is not necessary. Plasma AUC levels of sitagliptin were increased approximately 2-fold and 4-fold in patients with moderate renal insufficiency and in patients with severe renal insufficiency, including patients with ESRD on hemodialysis, respectively. Sitagliptin was modestly removed by hemodialysis (13.5% over a 3- to 4-hour hemodialysis session starting 4 hours postdose). To achieve plasma concentrations of sitagliptin similar to those in patients with normal renal function, lower dosages are recommended in patients with moderate and severe renal insufficiency, as well as in ESRD patients requiring hemodialysis. (See Dosage and Administration (2.2).) Hepatic Insufficiency In patients with moderate hepatic insufficiency (Child-Pugh score 7 to 9), mean AUC and Cmax of sitagliptin increased approximately 21% and 13%, respectively, compared to healthy matched controls following administration of a single 100 mg dose of JANUVIA. These differences are not considered to be clinically meaningful. No dosage adjustment for JANUVIA is necessary for patients with mild or moderate hepatic insufficiency. There is no clinical experience in patients with severe hepatic insufficiency (Child-Pugh score greater than9). Body Mass Index (BMI) No dosage adjustment is necessary based on BMI. Body mass index had no clinically meaningful effect on the pharmacokinetics of sita
'"/>




Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32

Related medicine technology :

1. Phase 3 Results for Dabigatran Etexilate, an Investigational Oral Anticoagulant, Presented Today at the XXIst Congress of the International Society on Thrombosis and Haemostasis
2. Late Breaking Data Released at ADA Showed that the Investigational Use of Januvia and Metformin as Initial Combination Therapy Provided Significant Glucose Lowering Efficacy over 54 Weeks in Patients with Type 2 Diabetes
3. Investigational Study Demonstrated a Re-Establishment of Clinical Improvement with Orencia (Abatacept) in Children with Juvenile Idiopathic Arthritis upon Re-Introduction of Therapy
4. Mercks Investigational Migraine Treatment MK-0974 Significantly Improved Migraine Pain on Several Efficacy Measures in a Phase II Study
5. Data Demonstrated Metastatic Melanoma Response to Investigational Immunotherapy Ipilimumab
6. Investigational Drug Cediranib (AZD2171) Shows Promise in Patients With Recurrent Glioblastoma (GBM)
7. Additional New Data from Satraplatin SPARC Phase 3 Investigational Trial Presented at ASCO Annual Meeting
8. Additional New Data from Satraplatin SPARC Phase 3 Investigational Trial Presented at ASCO Annual Meeting
9. Investigational Cancer Drug Pertuzumab Shows Promising Results in Advanced Breast Cancer When Combined with Herceptin
10. Shire Announces Positive Results of Studies With Guanfacine Extended Release, An Investigational Nonstimulant Medication Filed for the Treatment of ADHD in Children and Adolescents
11. Investigational Study Evaluates the Effectiveness of Aripiprazole in Adolescents With Schizophrenia
Post Your Comments:
(Date:11/24/2014)... DIEGO , Nov. 24, 2014  GlySens Incorporated ... two million dollar grant from the National Institute of ... of the National Institutes of Health (NIH).  The grant ... GlySens second generation ICGM™ long term implantable glucose monitoring ... underway, and enrollment is expected to begin before the ...
(Date:11/24/2014)... Pa. , Nov. 24, 2014  Inovio Pharmaceuticals, Inc. ... J. Joseph Kim , President and CEO of Inovio Pharmaceuticals, ... management team to ring the Nasdaq Opening Bell tomorrow, Tuesday ... Inovio,s September 15 th listing on the Nasdaq Global ... ceremony, Dr. Kim said, "We are honored to ring the ...
(Date:11/22/2014)... 2014  New data demonstrates that flibanserin, a novel, ... of female sexual dysfunction, Hypoactive Sexual Desire Disorder (HSDD), ... in premenopausal women when taken at bedtime. The data ... North America,s (SMSNA) 20th Annual Fall ... SMSNA accepted this study as a late ...
Breaking Medicine Technology:GlySens Incorporated Awarded $2 Million Grant from the National Institutes of Health 2Inovio Pharmaceuticals to Ring Opening Bell Nov 25th on the Nasdaq Stock Market 2Inovio Pharmaceuticals to Ring Opening Bell Nov 25th on the Nasdaq Stock Market 3Study on Efficacy and Sedation-Related Safety of Flibanserin in Premenopausal Women Released Today at Sexual Medicine Society of North America Meeting 2Study on Efficacy and Sedation-Related Safety of Flibanserin in Premenopausal Women Released Today at Sexual Medicine Society of North America Meeting 3
... The National,Comprehensive Cancer Network (NCCN) announces updates to ... Cancer,and Gastric Cancer. The NCCN Guidelines are updated ... recognized and,applied as the standard of care in ... and the academic practice settings., In response to ...
... of the Most Challenging Patient Populations,Studied of Any ... PARK, Calif., May 22, 2007,/PRNewswire-FirstCall/ -- XTENT, Inc. ... clinical trial, which assessed,the safety and efficacy of ... for the treatment of long and,multiple lesions in ...
Cached Medicine Technology:NCCN Updates Esophageal and Gastric Cancer Guidelines 2NCCN Updates Esophageal and Gastric Cancer Guidelines 3XTENT Announces Promising Six-Month Custom II Trial Data Presented,at EuroPCR Meeting 2XTENT Announces Promising Six-Month Custom II Trial Data Presented,at EuroPCR Meeting 3XTENT Announces Promising Six-Month Custom II Trial Data Presented,at EuroPCR Meeting 4
(Date:11/24/2014)... 24, 2014 Gersowitz Libo & Korek, P.C., ... received national Tier recognition in the 2015 Edition of U.S. ... ranking signals a unique combination of quality law practice and ... receive this honor and especially grateful to our clients whose ... and ranking possible,” said Jeff S. Korek, senior partner at ...
(Date:11/23/2014)... iFitDress.com, a well-known wedding dress manufacturer, has unveiled ... They are now offered at deeply discounted prices, up ... now to Dec. 15. The main purpose of the promotion ... high quality items are ideal options for ladies who are ... money. All its new mint cocktail dresses are very beautiful; ...
(Date:11/23/2014)... November 23, 2014 Pro Ace Care, a ... it will now be providing an 8 year warranty on ... water tank installations went up due to the impending winter ... its customers of the premium service that the company provides. ... year warranty on John Wood and Bradford hot water tanks. ...
(Date:11/23/2014)... 2014 Locks-Magnetic.com, a notable magnetic locks ... all the new products are available at low rates ... is proud of the new emergency doors. The emergency ... customers can choose from several colors. All of the ... emergency door release is not as easy as many ...
(Date:11/23/2014)... More than two dozen new claims ... litigation involving Byetta lawsuits ( http://www.byettalawsuit2013.com/ ), as well ... reports. , A Case List updated on November ... Type 2 diabetes medications referred to as incretin mimetics ... Southern District of California, where a federal proceeding continues ...
Breaking Medicine News(10 mins):Health News:U.S. News-Best Lawyers “Best Law Firms” Names Gersowitz Libo & Korek P.C. a 2015 Tier 1 Ranking Firm 2Health News:Trendy Long Black Evening Gowns Now Provided By iFitDress.com 2Health News:Pro Ace Care Now Gives 8 Year Guarantee on Selected Vancouver Hot Water Tanks 2Health News:California Federal Court Overseeing Byetta Lawsuits, Other Incretin Mimetic Claims Adds New Cases in November, Bernstein Liebhard LLP Reports 2Health News:California Federal Court Overseeing Byetta Lawsuits, Other Incretin Mimetic Claims Adds New Cases in November, Bernstein Liebhard LLP Reports 3Health News:California Federal Court Overseeing Byetta Lawsuits, Other Incretin Mimetic Claims Adds New Cases in November, Bernstein Liebhard LLP Reports 4
... after women have separated from an abusive partner, the violence still ... at the University of British Columbia. Led by UBC Nursing ... of Canadian Public Policy is the first in ... used by women who leave a violent partner. Overall, ...
... and Reinvestment Act award from the Agency for Healthcare ... Indiana Network for Patient Care (INPC), the nation,s largest ... simultaneously supports a groundbreaking comparative effectiveness research study using ... harms of three drugs commonly used to treat Alzheimer,s ...
... A pioneering international collaboration forged by Fred Hutchinson ... with the Uganda Cancer Institute in Kampala, Uganda, ... a state-of-the-art cancer training and outpatient treatment facility ... comprehensive cancer center jointly constructed by U.S. and ...
... by University of Cincinnati (UC) faculty members shows that ... clinical experience helps internal medicine residents improve their scores ... findings, published in the advance online edition of the ... print in November, validate the benefit of this and ...
... of 606 Canadian physicians were disciplined by their provincial ... St. Michael,s Hospital found. The majority of disciplined ... practicing medicine for a long time (an average of ... according to Dr. Chaim Bell. The most frequent ...
... wild, poisonous mushroom growing in a Southwest China forest appears ... report. , The compound, verticillin A, sensitizes cancer cells to ... said Dr. Kebin Liu, cancer immunologist at the Georgia Health ... in the journal Cancer Research . , The compound ...
Cached Medicine News:Health News:Annual cost of violence pegged at $6.9 billion after women leave abusive partners, UBC research 2Health News:$8.4 million grant supports health information exchange and research on Alzheimer's drugs 2Health News:Hutchinson Center breaks ground for first collaborative cancer center in sub-Saharan Africa 2Health News:Hutchinson Center breaks ground for first collaborative cancer center in sub-Saharan Africa 3Health News:Hutchinson Center breaks ground for first collaborative cancer center in sub-Saharan Africa 4Health News:Hutchinson Center breaks ground for first collaborative cancer center in sub-Saharan Africa 5Health News:New testing program improves scores, knowledge retention for third-year internal medicine residents 2Health News:New testing program improves scores, knowledge retention for third-year internal medicine residents 3Health News:Researchers track number of doctors disciplined and why 2Health News:Mushroom compound appears to improve effectiveness of cancer drugs 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: