Navigation Links
An Investigational Study Released at ADA Showed that Initial,Combination Therapy with Januvia (sitagliptin) and Metformin Led to,Improvement in Markers of Beta Cell Function in Patients with Type,2 Diabetes

g dose. In patients with type 2 diabetes administered JANUVIA 100 mg (N=81) or JANUVIA 200 mg (N=63) daily, there were no meaningful changes in QTc interval based on ECG data obtained at the time of expected peak plasma concentration. 12.3 Pharmacokinetics The pharmacokinetics of sitagliptin has been extensively characterized in healthy subjects and patients with type 2 diabetes. After oral administration of a 100 mg dose to healthy subjects, sitagliptin was rapidly absorbed, with peak plasma concentrations (median Tmax) occurring 1 to 4 hours postdose. Plasma AUC of sitagliptin increased in a dose-proportional manner. Following a single oral 100 mg dose to healthy volunteers, mean plasma AUC of sitagliptin was 8.52 ?M-hr, Cmax was 950 nM, and apparent terminal half-life (t1/2) was 12.4 hours. Plasma AUC of sitagliptin increased approximately 14% following 100 mg doses at steady-state compared to the first dose. The intra-subject and inter-subject coefficients of variation for sitagliptin AUC were small (5.8% and 15.1%). The pharmacokinetics of sitagliptin was generally similar in healthy subjects and in patients with type 2 diabetes. Absorption The absolute bioavailability of sitagliptin is approximately 87%. Because coadministration of a high-fat meal with JANUVIA had no effect on the pharmacokinetics, JANUVIA may be administered with or without food. Distribution The mean volume of distribution at steady state following a single 100 mg intravenous dose of sitagliptin to healthy subjects is approximately 198 liters. The fraction of sitagliptin reversibly bound to plasma proteins is low (38%). Metabolism Approximately 79% of sitagliptin is excreted unchanged in the urine with metabolism being a minor pathway of elimination. Following a (14C)sitagliptin oral dose, approximately 16% of the radioactivity was excreted as metabolites of sitagliptin. Six metabolites were detected at trac
'"/>




Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32

Related medicine technology :

1. Phase 3 Results for Dabigatran Etexilate, an Investigational Oral Anticoagulant, Presented Today at the XXIst Congress of the International Society on Thrombosis and Haemostasis
2. Late Breaking Data Released at ADA Showed that the Investigational Use of Januvia and Metformin as Initial Combination Therapy Provided Significant Glucose Lowering Efficacy over 54 Weeks in Patients with Type 2 Diabetes
3. Investigational Study Demonstrated a Re-Establishment of Clinical Improvement with Orencia (Abatacept) in Children with Juvenile Idiopathic Arthritis upon Re-Introduction of Therapy
4. Mercks Investigational Migraine Treatment MK-0974 Significantly Improved Migraine Pain on Several Efficacy Measures in a Phase II Study
5. Data Demonstrated Metastatic Melanoma Response to Investigational Immunotherapy Ipilimumab
6. Investigational Drug Cediranib (AZD2171) Shows Promise in Patients With Recurrent Glioblastoma (GBM)
7. Additional New Data from Satraplatin SPARC Phase 3 Investigational Trial Presented at ASCO Annual Meeting
8. Additional New Data from Satraplatin SPARC Phase 3 Investigational Trial Presented at ASCO Annual Meeting
9. Investigational Cancer Drug Pertuzumab Shows Promising Results in Advanced Breast Cancer When Combined with Herceptin
10. Shire Announces Positive Results of Studies With Guanfacine Extended Release, An Investigational Nonstimulant Medication Filed for the Treatment of ADHD in Children and Adolescents
11. Investigational Study Evaluates the Effectiveness of Aripiprazole in Adolescents With Schizophrenia
Post Your Comments:
(Date:11/26/2014)... , Nov. 26, 2014  Perrigo Company plc ... global provider of "Quality Affordable Healthcare Products®," today announced ... relating to the sale of 6,809,210 ordinary shares at ... the full exercise of the option to purchase up ... Securities LLC and Barclays Capital Inc., as representatives of ...
(Date:11/26/2014)... Texas , Nov. 26, 2014 ... today announced the completion of previously announced concurrent ... million.  After fees and estimated offering expenses, Lexicon ... the transactions.  The transactions consisted of: ... common stock, pursuant to a registration statement that ...
(Date:11/26/2014)... Md. , Nov. 26, 2014  Over 100 ... of those suffer from this pain daily. Chronic and ... of pain management is born to fulfill the need ... all types of pain. On October 28th, ... the Cumberland, Maryland community.  This ...
Breaking Medicine Technology:Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 2Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 3Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 4Lexicon Announces Completion Of $280 Million In Financing Transactions 2Lexicon Announces Completion Of $280 Million In Financing Transactions 3New Pain Management Center Opens in Cumberland, Md. 2
... CITY, Calif., Jan. 4, 2011 Arstasis is pleased ... to physicians, nurses, patients, and cath lab technicians across ... of physicians participating in Arstasis clinical trials and select ...  As of today, the company is making the simple-to-use, ...
... 4, 2011 Isis Pharmaceuticals, Inc. (Nasdaq: ... Recent Advances in Isis, Development PipelineWhen: , Thursday, ... 9:00 a.m. PTWhere: , www.isispharm.comHow: , Live on ... listed above. Contacts: , Kristina LemonidisDirector, Investor Relations(760) ...
Cached Medicine Technology:Nationwide Launch of Arstasis One Access Device Provides Cath Labs Across the U.S. an Alternative to Standard Arteriotomies and Vascular Closure Implants 2
(Date:11/28/2014)... An inventor and dental assistant from Kent, Wash., was ... it was almost impossible to reach. "This gave me the ... The patent-pending Access Light allows for easier use of a ... mouth, as well as avoids harm to the lips, tongue ... and clean, it also helps prevent cross-contamination. , The original ...
(Date:11/28/2014)... York, New York (PRWEB) November 28, 2014 ... ( http://www.consumerinjurylawyers.com/stryker-rejuvenate/stryker-hip-lawsuits/ ) have now been filed in ... of recalled metal implants, Bernstein Liebhard LLP reports. ... 18th in Bergen County Superior Court reflects the ... ABG II modular-neck hip stems, which were voluntarily ...
(Date:11/28/2014)... Lice Troopers Lice Removal Service is pleased ... head lice service for moms in Miami-Dade County. Lice Troopers ... Gables on Pone De-leon Blvd in Miami. The company ... service Miami-Dade & Broward. Lice Troopers is the only Lice ... has been treating families for several years. , Lice Troopers ...
(Date:11/28/2014)... November 28, 2014 An inventor from Flint, ... to day. "I got this idea while lying in a ... bathroom," he said. , The Bed Buddy provides a more ... to the bathroom. It eliminates the need to leave the ... comfort and dignity. Easy to use and producible in design ...
(Date:11/28/2014)... (PRWEB) November 28, 2014 ARTAS robotic ... for the first time. PAI Medical Group hair transplant ... be performing a robotic hair transplant procedure in the ... A.M. , The first in Tennessee and one of ... Group now offers ARTAS robotic hair transplantation. Patients benefit ...
Breaking Medicine News(10 mins):Health News:More than 2,100 Stryker Hip Lawsuits Included in New Jersey Litigation after Settlement Announcement, Bernstein Liebhard LLP Reports 2Health News:More than 2,100 Stryker Hip Lawsuits Included in New Jersey Litigation after Settlement Announcement, Bernstein Liebhard LLP Reports 3Health News:Lice Troopers Lice Removal Service Expands in Miami-Dade 2Health News:First in Tennessee - PAI Medical Group Announces ARTAS - The World’s Most Advanced Medical Robot Used for Hair Transplant Surgery 2
... treatments down the road, researchers say , WEDNESDAY, May ... geneticists have identified a genetic mutation that appears to ... most common major birth defect. , Congenital heart disease ... compared to diseases like cancer, according to study author ...
... food industry is ,trying to do the right thing, researcher ... removing harmful trans fats from foods would open the door ... foods seem to be unfounded, a new study finds. , ... reformulated products from supermarkets and restaurants, and found little cause ...
... University Hospitals has been designated as a Neuroscience Center ... Excellence Survey sponsored by NeuStrategy, Inc., Chicago. It ... the Stage 4 Institute designation. The ... in the neurosciences and is the industry standard for ...
... levels of hormone that triggers the need for a night,s ... 26 (HealthDay News) -- Brain injuries can disrupt the body,s ... a new study suggests. , "We,ve known that people often ... haven,t known much about the exact causes of these problems," ...
... under trade name Xenical and over-the-counter as Alli , ... of rare but sometimes severe cases of liver damage, ... a widely used weight-loss drug. , The drug, orlistat, ... and over-the-counter as Alli. , Thirteen cases of severe ...
... of individualized therapies, experts say , WEDNESDAY, May 26 (HealthDay ... two, but potentially tens of thousands of genetic mutations which, ... sample from a lung tumor from a heavy smoker revealed ... issue of Nature . , "People in the field ...
Cached Medicine News:Health News:Gene Mutation Linked to Congenital Heart Disease 2Health News:Healthier Fats Replacing Trans Fats, Study Finds 2Health News:Healthier Fats Replacing Trans Fats, Study Finds 3Health News:University Hospitals Neurological Institute earns Neuroscience Center of Excellence designation 2Health News:Brain Injuries May Lead to Sleep Woes 2Health News:Rare Cases of Liver Damage Tied to Weight-Loss Drug 2Health News:Rare Cases of Liver Damage Tied to Weight-Loss Drug 3Health News:Single Lung Tumor Contains 50,000 Mutations 2
... Features exclusive micro-prism refractive technology that ... distributed light onto the surgical site. ... unmatched combination of cavity illumination, shadow ... representation. The highly maneuverable PrismAlix Series ...
Flat tip, bare fiber, no cooling, polished SMA 905, 3 meters long. Sold in boxes of five. Each part is individually packaged in sterile Tyvek bags....
One piece, 100% fused silica construction offers low scatter and high efficiency...
Stirrups provide a safe system for positioning patients in a variety of lithotomy positions. Power-assisted positioning, as well as abduction, assures proper positioning of the patient. Includes one ...
Medicine Products: