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An Investigational Study Released at ADA Showed that Initial,Combination Therapy with Januvia (sitagliptin) and Metformin Led to,Improvement in Markers of Beta Cell Function in Patients with Type,2 Diabetes

eactions Reported in Greater than or equal to 5% of Patients and More Commonly than in Patients Given Placebo, Regardless of Investigator Assessment of Causality+ ---------------------------------------------------------------------- Number of Patients (%) ---------------------------------------------------------------------- Monotherapy JANUVIA 100 mg Placebo ---------------------------------------------------------------------- N = 443 N = 363 ---------------------------------------------------------------------- Nasopharyngitis 23 (5.2) 12 (3.3) ---------------------------------------------------------------------- Combination with Pioglitazone JANUVIA 100 mg + Placebo + Pioglitazone Pioglitazone ---------------------------------------------------------------------- N = 175 N = 178 ---------------------------------------------------------------------- Upper Respiratory Tract Infection 11 (6.3) 6 (3.4) ---------------------------------------------------------------------- Headache 9 (5.1) 7 (3.9) ---------------------------------------------------------------------- + Intent to treat population In patients receiving JANUVIA in combination with metformin, there were no adverse reactions reported regardless of investigator assessment of causality in greater than or equal to 5% of patients and more commonly than in patients given placebo. The overall incidence of hypoglycemia in patients treated with JANUVIA 100 mg was similar to placebo (1.2% vs 0.9%). The incidence of selected gastrointestinal adverse reactions in patients treated with JANUVIA was as follows: abdominal pain (JANUVIA 10
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