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An Investigational Study Released at ADA Showed that Initial,Combination Therapy with Januvia (sitagliptin) and Metformin Led to,Improvement in Markers of Beta Cell Function in Patients with Type,2 Diabetes

CHICAGO--(BUSINESS WIRE)--Jun 25, 2007 - New data from an investigational study released at the American Diabetes Association (ADA) 67th Annual Scientific Sessions showed that initial combination therapy with Januvia(TM) (sitagliptin) and metformin demonstrated significant improvement in markers of beta cell function in patients with type 2 diabetes. Pancreatic islet beta cell function determines the ability of the body to produce insulin, a hormone which plays a central role in the regulation of blood sugar levels. New data from a separate pharmacologic study reported today in an oral presentation revealed that, when used in combination in healthy adults, the different mechanisms of action of JANUVIA and metformin had a complementary effect on glucagon-like peptide-1 (GLP-1) levels, another hormone that is an important regulator of blood sugar levels. This aspect of the mechanism of action of metformin used in combination with JANUVIA was previously unknown. GLP-1 acts, in part, by enhancing pancreatic beta cell insulin production and secretion.

JANUVIA is a selective, once-daily dipeptidyl peptidase-4 (DPP-4) inhibitor that enhances a natural body system, called the incretin system, which helps to regulate glucose by affecting the beta cells and alpha cells in the pancreas. JANUVIA is the first and only DPP-4 inhibitor to be approved and marketed in the United States for patients with type 2 diabetes. JANUVIA is indicated, as an adjunct to diet and exercise, to improve glycemic control in patients with type 2 diabetes mellitus. JANUVIA is also indicated to improve glycemic control, in combination with metformin or a thiazolidinedione (TZD), in patients with type 2 diabetes when the single agent alone plus diet and exercise do not provide adequate glycemic control. JANUVIA should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis, as it would not be effective in these se
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