Navigation Links
Amsterdam Molecular Therapeutics BV to present preclinical,proof-of-concept data on its gene therapy AMT-020 to treat acute,intermittent porphyria

The research, done in collaboration with the Centro de Investigación Médica Aplicada (CIMA) at the University of Navarra, Pamplona, Spain, is being presented at Porphyrins and Porphyrias Congress, Rotterdam, the Netherlands.

AMSTERDAM, the Netherlands, May 1st 2007 - Amsterdam Molecular Therapeutics BV (AMT), a leader in the field of human gene therapy, will today present preclinical data on its AMT-020 gene therapy to treat acute intermittent porphyria (AIP) at the Porphyrins and Porphyrias Congress, Rotterdam.

The data suggest that AMT-020 has the potential to protect patients suffering from recurrent porphyria attacks and/or neuropathy.

AMT-020 is comprised of an Adeno-Associated Virus (AAV) vector delivering the gene for porphobilinogen deaminase (PBGD). The aim of this study, which was performed by Dr's Fontanellas, González-Aseguinolaza and Prieto at CIMA, was to investigate the potential of AMT-020 to protect against acute attack induced by phenobarbital (Pb) in a mouse model of AIP. The model reproduces key features of AIP attack after Pb induction, including increased urinary excretion of haem precursors and decreased motor function.

PBGD-deficient female and male mice were intravenously injected with 1x1011 gc/mouse of AMT-020. Control animals received the same AAV vector but carried the luciferase reporter gene.

One month after injection, both groups were treated with an increasing dose of Pb for 4 days to induce a porphyria attack. The results showed that porphyric mice that received AMT-020 had almost normal haem precursors in the urine and normal motor function, indicating that the treatment completely prevented the occurrence of porphyric attacks.

"These results are very encouraging, and show the potential of AMT-020 to treat AIP," said Sander van Deventer, CSO at AMT, who presented the data. "The next stage in the development of the
'"/>




Page: 1 2 3

Related medicine technology :

1. Molecular Target of Bradmers Neuradiab Further Validated by Independent Findings
2. Molecular Insight Pharmaceuticals, Inc. Presents Preclinical Data on Molecular Imaging Pharmaceutical for Prostate Cancer
3. Molecular Insight Pharmaceuticals, Inc. Presents Preclinical Data at Society Of Nuclear Medicine 2007 Annual Meeting
4. DNA Therapeutics Reports a Novel Mechanism of Action and a Biomarker of its Lead Molecule Dbait That Open an Innovative Pathway-Targeting in Molecular Cancer Therapy
5. Avid Announces Results of AV-1 Molecular Imaging Agent for Alzheimers Disease Presented at AD/PD Meeting
6. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
7. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
8. CV Therapeutics Identifies Potential Anti-Diabetic Mechanism of Action for Ranexa
9. Fat Kills Cancer: Turning Stem Cells from Fat Tissue into Personalized, Cancer-Targeted Therapeutics
10. A 4-Week Therapy with Transition Therapeutics E1-I.N.T. Leads to Sustained Reductions in Blood Glucose Levels for 6 Months Post-treatment in Type 2 Diabetes Patients
11. Clinical Trial Suggests Bone Marrow Stem Cells Are Useful for Spinal Cord Injury; PrimeCell Therapeutics Provided Pre-Clinical Study
Post Your Comments:
(Date:9/19/2014)... -- According to the new research ... Hydrotherapy), Accessories (Posture Mirror, Exercise Ball), Applications (Pediatric, Musculoskeletal) ... Forecast to 2019" published by MarketsandMarkets, the global Physiotherapy ... by 2019 from $14,240.0 Million in 2014, at ... Browse 74 market data tables and ...
(Date:9/19/2014)... STATION, N.J. , Sept. 19, 2014 Merck (NYSE: ... United States and Canada , is ... Desafiando La Diabetes: Logra Tus Metas , an educational program ... their blood sugar -- a key treatment goal to help reduce ... United States are at a higher risk for developing ...
(Date:9/19/2014)... 19, 2014 Five MinuteClinic walk-in medical clinics are opening ... metropolitan area. Three clinics opened in Memphis ... clinic will be added in Springfield on ... is expected to open October 22.  MinuteClinic is the largest ... the United States . The Memphis ...
Breaking Medicine Technology:Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 2Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 3Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 4Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 2Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 3Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 4Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 5MinuteClinic Walk-in Medical Clinics Opening in Memphis 2MinuteClinic Walk-in Medical Clinics Opening in Memphis 3
... Md., Oct. 19, 2011 /PRNewswire-iReach/ -- Precision Antibody™ ... Drug Administration (FDA) to develop monoclonal antibodies to influenza virus ... be used for in vitro assays to develop new vaccine ... production contract is for one year with the option of ...
... Oct. 19, 2011 Sharon Ladin, director of ... issued the following statement regarding the bipartisan, bicameral ... by Sen. Richard Blumenthal (D-Conn.) and Sen. Bob ... H.R. 2182 and contains provisions to incentivize the ...
Cached Medicine Technology:FDA Awards Precision Antibody Contract to Develop Monoclonal Antibodies for Influenza Vaccine Potency Assays 2FDA Awards Precision Antibody Contract to Develop Monoclonal Antibodies for Influenza Vaccine Potency Assays 3
(Date:9/19/2014)... In partnership with Raw Beauty NYC, ... of the project’s social media efforts. StudioPMG is honored to ... the perception of beauty as it applies to disabled women. ... by Shelly Baer and Vanessa Silberman, who wanted to create ... beautiful. Ginny Dixon, Wendy Crawford, Susan Solman and Sabrina Cohen ...
(Date:9/19/2014)... violence occurs at least as frequently, and likely ... opposite-sex couples, according to a review of literature ... studies, when analyzed together, indicate that domestic violence ... gay and bisexual individuals. However, a lack of ... incomplete picture of the true landscape, suggesting even ...
(Date:9/19/2014)... Mayo Clinic have discovered a defect in a key ... toxic protein in the brains of Alzheimer,s disease ... neurons both significant contributors to this type of ... Neuron , offers the potential that ... rescue this pathway," says the study,s lead investigator, ...
(Date:9/19/2014)... September 20, 2014 As summer vacations end ... in Queens, NY now reminds area patients about the reality ... of our population affected by gum disease, there is simply ... For over 20 years Dr. Krishnan has treated patients with ... location. “Most patients that come in due to common symptoms ...
(Date:9/19/2014)... 2014 (HealthDay News) -- More states are passing legislation ... to use for any child having a severe allergic ... "anaphylaxis," an allergic reaction that can lead to throat ... and even death. In people with severe ... nuts, insect venom or certain drugs, anaphylaxis can occur ...
Breaking Medicine News(10 mins):Health News:OC Healthcare Agency StudioPMG Partners with The Raw Beauty Project ™ NYC 2014 2Health News:Domestic violence likely more frequent for same-sex couples 2Health News:Mayo researchers reveal pathway that contributes to Alzheimer's disease 2Health News:New York Periodontist Dr. Prabha Krishnan Now Raises Awareness about the Dangers of Untreated Decay, Gingivitis and Gum Disease During Self-Awareness Month 2Health News:New York Periodontist Dr. Prabha Krishnan Now Raises Awareness about the Dangers of Untreated Decay, Gingivitis and Gum Disease During Self-Awareness Month 3Health News:More Schools Stocking Shots That Counter Serious Allergic Reactions 2Health News:More Schools Stocking Shots That Counter Serious Allergic Reactions 3
... SUNDAY, Dec. 4 (HealthDay News) -- Variations in genes ... to attention-deficit/hyperactivity disorder (ADHD), according to a new study. ... these pathways may offer a new treatment option for ... of Philadelphia researchers said. In the study, researchers ...
... (HealthDay News) -- Children who suffer head trauma can experience headaches ... than boys, a new study finds. The researchers also found ... mild traumatic brain injury (TBI) than after a moderate or severe ... Pediatrics , included children aged 5 to 17 who ...
... and non-obese children found that low vitamin D levels are ... risk factors for type 2 diabetes. This study was accepted ... Endocrinology & Metabolism (JCEM). High rates of vitamin ... studies have linked low vitamin D levels to cardiovascular disease ...
... new studies from the University of New Hampshire Crimes against ... be overblown. One study found the percentage of youth who ... pornography is very low. The other found that when teen ... being arrested or treated like sex offenders. The studies ...
... , SUNDAY, Dec. 4 (HealthDay News) --,A region ... responsible for laughter, new research suggests. Researchers from ... with a rare disorder, gelastic epilepsy, which is ... into groups: those with laughing seizures only, those with ...
... By E.J. Mundell HealthDay Reporter , FRIDAY, Dec. ... did actress and health advocate Dana Reeve, wife of the late ... 2006, respectively, both joined the ranks of about 32,000 Americans each ... anyway. In fact, experts say, one in every five cases ...
Cached Medicine News:Health News:More Evidence Links Specific Genes to ADHD 2Health News:Girls More Prone Than Boys to Headaches After Head Injury 2Health News:Low vitamin D levels may contribute to development of Type 2 diabetes 2Health News:Concerns about teen sexting overblown, according to new UNH research 2Health News:Lung Cancer's Hidden Victims: Those Who Never Smoked 2Health News:Lung Cancer's Hidden Victims: Those Who Never Smoked 3
... is a mechanical catheter intended to percutaneously ... access grafts. The disposable catheter requires no ... spiral shaft which extends beyond the 6F ... tip. In use, the tip spins to ...
... HYDROLYSER Percutaneous Thrombectomy Catheter is ... for rapid, effective and easy removal ... shunts. The HYDROLYSER catheter provides an ... thrombolytic therapy. ,Compatible with ...
Introduced more than 30 years ago by Dr. Thomas J. Fogarty, these embolectomy catheters are indicated for the removal of fresh, soft emboli and thrombi from vessels in the arterial system....
... The AVX catheter is designed to ... 12mm. High-pressure saline jets travel backwards ... to create a low pressure zone ... drawn into the catheter where it ...
Medicine Products: