Navigation Links
Alnylam and Stanford University Scientists Discover New Role for,microRNAs (miRNAs) in T Cell Biology and Immunity

i, is a naturally occurring mechanism within cells for selectively silencing and regulating specific genes. The discovery of RNAi has been widely acknowledged as a major breakthrough in biology, and the technology was recognized for its potential broad impact in medicine with the award of the 2006 Nobel Prize for Physiology or Medicine. Since many diseases are caused by the inappropriate activity of specific genes, the ability to silence genes selectively through RNAi could provide a new way to treat a wide range of human diseases. RNAi is induced by small, double-stranded RNA molecules. One method to activate RNAi is with chemically synthesized small interfering RNAs, or siRNAs, which are double-stranded RNAs that are targeted to a specific disease-associated gene. The siRNA molecules are used by the natural RNAi machinery in cells to cause targeted gene silencing.

About microRNA (miRNA)

RNAi can also be induced by microRNAs, or miRNAs, that occur naturally within all mammalian cells. The miRNA molecules are encoded by the cell's own genes, giving rise to small RNA molecules that are similar in structure to siRNAs. There are believed to be over 250 confirmed miRNA genes in the human genome and there are many other predicted miRNAs. miRNAs are thought to work through RNAi to regulate the activity of an estimated one-third of genes in the genome. The inappropriate absence or presence of specific miRNA molecules in various cells has been shown to be associated with specific human diseases, including cancer and viral infections.

About Alnylam

Alnylam is a biopharmaceutical company developing novel therapeutics based on RNA interference, or RNAi. The company is applying its therapeutic expertise in RNAi to address significant medical needs, many of which cannot effectively be addressed with small molecules or antibodies, the current major classes of drugs. Alnylam is building a pipeline of RNAi therapeutics; its lead program is in Phase I hum
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Alnylam Reports Results of Human Experimental Infection Model with Respiratory Syncytial Virus
2. Alnylam Announces Advancement of a New RNAi Therapeutic Development Program for the Treatment of Liver Cancer
3. Stanford Researchers Find Brain Pathway of Depression in Rats
4. Common Preterm Labor Drug Has More Side Effects Than Alternative, Finds Study from Packard Childrens Hospital and Stanford
5. Stanford Researchers Track Human Stem Cells Transplanted Into Rat Brain
6. Once-Fatal Metabolic Disorders Treatable, Says Stanford/Packard Researcher
7. Limiting Eligibility for Medical Studies Can Omit Women, African-Americans, Stanford Study Finds
8. Fragile X, Down Syndromes Linked to Faulty Brain Communication, Stanford Researcher Finds
9. Stanford Study Finds No Conclusive Benefit From Treating Kleptomania With Medication
10. Study of Drug Therapy for Compulsive Buying Yields a Puzzle, Stanford Researcher Says
11. Bio-Matrix Scientifics Dr. ONeill Sees University of Pittsburghs Published Study on Culture Blood-Forming Stem Cells from Human Fat Tissue as Supporting Near Term Benefits of Banking Adipose (Fat) Derived Stem Cells
Post Your Comments:
(Date:7/11/2014)... , July 11, 2014  Kindred Hospital Houston ... announce the opening of its new outpatient wound ... services to people with chronic, hard to heal ... can lead to amputation, lower leg wounds related ... delayed closure, and traumatic injury wounds which are ...
(Date:7/11/2014)... ST. LOUIS , July 11, 2014 ... medical device company, announced today the positive, ... of its innovative SPiNPerc™ procedure. The SPiNPerc ... use of a percutaneous approach to biopsy ... possible.  Hospitals, patients and physicians experience positive ...
(Date:7/10/2014)... CLEVELAND , July 10, 2014  The U.S. ... a three-year grant to University Hospitals (UH) Case Medical ... a new national model aimed at improving care for ... Oncology Care," the project will test a unique model ... patients with late-stage disease, significant comorbidities, or demonstrated need ...
Breaking Medicine Technology:Kindred Hospital Houston Northwest, With Wound Care Specialists, Opens Outpatient Wound Healing And Hyperbaric Center 2Veran Medical Publishes Lung Cancer Patient Management Study 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 3University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 4
... N.J., Oct. 27 Savient Pharmaceuticals, Inc. (Nasdaq: ... results for the third quarter 2010 following the close of ... Paul Hamelin, President, and David Gionco, Group Vice President, Chief ... call beginning at 9:00 a.m. Eastern Time on Friday, November ...
... 27 Express Scripts, Inc. (Nasdaq: ESRX ) announced ... or $0.57 per diluted share.  Third quarter adjusted earnings per share, ... increase of 55% over 2009. Third Quarter ... Tables 2 and 3) Total adjusted claims of ...
Cached Medicine Technology:Savient Pharmaceuticals to Hold Third Quarter 2010 Financial Results Conference Call on Friday, November 5, 2010 2Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 2Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 3Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 4Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 5Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 6Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 7Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 8Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 9Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 10Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 11Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 12Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 13Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 14Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 15Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 16
(Date:7/14/2014)... 14, 2014 Carepoint has been ... caregiving by combining an intuitive interface for recording, ... robust service tracking and reporting features. , Hall ... has teamed up with Rebecca de Witte to ... healthcare organizations. , Carepoint provides seamless, ...
(Date:7/14/2014)... 2014 Reha Technology today announced ... portable and full-featured upper extremity robotic trainer that ... interactive games and challenges in a lightweight and ... , Armotion combines a variety of ... maximize the therapy effect for patients with severe ...
(Date:7/14/2014)... Green Bay, WI (PRWEB) July 14, 2014 ... recently announced the launch of their new company ... to gather valuable free information on chiropractic marketing. It's ... the services that Inception has to offer. , When ... to release the newest version of our main website. ...
(Date:7/14/2014)... Beach, Calif. (PRWEB) July 14, 2014 ... protein bar and powder company Permalean for ... reputation. , Permalean, which markets its products ... Bars is now a part of EnergyFirst’s lineup ... integrated into EnergyFirst over the coming year. , Founded ...
(Date:7/14/2014)... 2014 Townsend Security, a leading ... new IBM i (AS/400, iSeries) Two Factor Authentication ... security threats evolve and make passwords ineffective for ... modernize their applications and implement two factor authentication ... easy for ISVs on the IBM i platform ...
Breaking Medicine News(10 mins):Health News:Home Health Care Professional and Marketing Firm Team Up to Create New Homecare Communication App 2Health News:Reha Technology Launches the Armotion™, a Device for the Rehabilitation of the Upper Extremity 2Health News:Doctor Mike Hamilton From Inception Chiropractic Websites Announces the Launch of Their New Website 2Health News:EnergyFirst Acquires Permalean - Manufacturer of All Natural Protein Bars and Powders 2Health News:EnergyFirst Acquires Permalean - Manufacturer of All Natural Protein Bars and Powders 3Health News:IBM i ISVs Can Now Easily Integrate Mobile-Based Two Factor Authentication to Increase Security of Solutions 2Health News:IBM i ISVs Can Now Easily Integrate Mobile-Based Two Factor Authentication to Increase Security of Solutions 3
... in halving the number of relapses experienced by people ... accounts for 12 per cent of suicides each year ... , With funding from the MBF Foundation and Beyond ... Institute of Victoria has developed an innovative structured group ...
... related costs increased 57% from 1999 to 2004, analysis shows ... been progress in the prevention and treatment of kidney failure ... a new analysis shows. , In 2004, the most recent ... 0.03 percent of the population) started dialysis or received a ...
... specializing in laparoscopic procedures at UT Southwestern Medical Center ... unique nephrectomy entirely through the belly button. , ... performed the single keyhole access surgery, the first of ... completed with only one incision and will leave the ...
... right up to the early 70s , , WEDNESDAY, Aug. 22 ... down their sex lives, a new study shows. , The ... problems of U.S. adults age 57 and older finds many ... sexual activity dropped only slightly between the late 50s up ...
... no coverage meant tumors were spotted later, study found , ... with no health insurance are more likely than those with ... cancer, a U.S. study finds. , Each year, about 10,000 ... laryngeal cancer. The stage of cancer at the time of ...
... of its kind, researchers have discovered that in autistic ... single regions, and not just between regions, as was ... assistant professor of neurology at Wake Forest University School ... lead to earlier diagnosis and more targeted medications for ...
Cached Medicine News:Health News:Bipolar disorder relapses halved by Melbourne researchers 2Health News:Expenses Overshadow Optimism for Kidney Failure Patients 2Health News:Single-incision belly-button surgery to remove kidney performed first at UT Southwestern 2Health News:Many Older Americans Have Active Sex Lives 2Health News:Many Older Americans Have Active Sex Lives 3Health News:Many Older Americans Have Active Sex Lives 4Health News:Insurance Impacts Laryngeal Cancer Detection 2Health News:Research may unlock mystery of autism's origin in the brain 2
... from DePuy offers a comprehensive combination of ... OSHA recommendations regarding occupational exposure to blood ... standard for comfort. , ,The Nighthawk, a ... from DePuy, is a personal protection system ...
... setup, try Cadwell paired disc electrodes. They ... custom-molded contacts are 10 mm (0.4 in) ... stainless steel with a locator pin on ... coded and available in twisted pairs. Shielded ...
... Headlight Video Camera System (NTSC)With Maxenon ... Provides surgeon's eye view of any ... tapes or digital files for later ... from 8" to 36". Automatic Iris ...
... Wrap-around, silver/silver chloride ring electrodes ... For use with minicrocodile clip ... 10 cm (4 in) long, ... Each 100-count package contains 50 ...
Medicine Products: