Navigation Links
Alnylam and Stanford University Scientists Discover New Role for,microRNAs (miRNAs) in T Cell Biology and Immunity

at Alnylam. "Moreover, this new paper in Cell continues Alnylam's commitment to scientific excellence and our broad leadership in RNAi research and its translation toward therapeutics."

T cells play a central and coordinating role in cell-mediated and acquired immunity. Recognition of both "self" and foreign molecules by T cells occurs through activation of a cell surface receptor called the T cell receptor. Activation of T cells through the T cell receptor involves the complex regulation of multiple biological pathways inside the cell. miRNAs are a broad class of small RNAs that have been shown to regulate the expression of a large number of genes in the human genome through the RNAi pathway, and many of these miRNAs are believed to be involved in disease processes. Certain miRNAs, including miR-181a, are known to play a role in B and T cell development, but their function in antigen recognition is poorly understood. Recently, Alnylam scientists and collaborators have discovered a new class of oligonucleotide therapeutics, called antagomirs, that inhibit the function of specific miRNAs in vitro and in vivo (Krutzfeldt et al. (2005) Nature 438, 685-689; Esau et al. (2006) Cell Metab., 3, 87-98).

In the current study, increasing expression of miR-181a was found to increase T cell sensitivity to antigens, while inhibiting miR-181a was found to decrease the immune response. miR-181a was found to regulate the responsiveness of the T cell receptor to antigens by the coordinated down-regulation of a set of phosphatase genes. Inhibiting miR-181a function with a selective antagomir, antagomir-181a, resulted in efficient reduction in T cell receptor sensitivity to antigens. Since abnormal T cell activity toward "self" antigens underscores the pathology in many autoimmune disorders, antagomirs selective for miR-181a could define a future therapeutic strategy for the treatment of these diseases.

About RNA Interference (RNAi)

RNA interference, or RNA
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Alnylam Reports Results of Human Experimental Infection Model with Respiratory Syncytial Virus
2. Alnylam Announces Advancement of a New RNAi Therapeutic Development Program for the Treatment of Liver Cancer
3. Stanford Researchers Find Brain Pathway of Depression in Rats
4. Common Preterm Labor Drug Has More Side Effects Than Alternative, Finds Study from Packard Childrens Hospital and Stanford
5. Stanford Researchers Track Human Stem Cells Transplanted Into Rat Brain
6. Once-Fatal Metabolic Disorders Treatable, Says Stanford/Packard Researcher
7. Limiting Eligibility for Medical Studies Can Omit Women, African-Americans, Stanford Study Finds
8. Fragile X, Down Syndromes Linked to Faulty Brain Communication, Stanford Researcher Finds
9. Stanford Study Finds No Conclusive Benefit From Treating Kleptomania With Medication
10. Study of Drug Therapy for Compulsive Buying Yields a Puzzle, Stanford Researcher Says
11. Bio-Matrix Scientifics Dr. ONeill Sees University of Pittsburghs Published Study on Culture Blood-Forming Stem Cells from Human Fat Tissue as Supporting Near Term Benefits of Banking Adipose (Fat) Derived Stem Cells
Post Your Comments:
(Date:8/27/2015)... According to a new market research report ... Standing, Bariatric ), Material (Nylon, Padded, Canvas), Usage Type (Disposable, Reusable), ... MarketsandMarkets, the Medical Lifting Sling Market is poised to reach USD ... a CAGR of 11.4 % from 2015 to 2020. ... data T ables and 65 F ...
(Date:8/27/2015)... 27, 2015   Proxsys Rx, the ... is expanding its population health management services ... of care program for hospitals and health ... hospitals with technology systems and pharmacy support ... have been mandated by Center for Medicare ...
(Date:8/27/2015)... NorthStar Anesthesia , one of the country,s leading anesthesia ... Mercy, based in Toledo, Ohio , to ... St. Vincent  Medical Center and Mercy St. Anne  Hospital ...  Hospital in Oregon and Mercy ... "As we looked to create a more organized approach ...
Breaking Medicine Technology:Medical Lifting Sling Market Worth USD 706.0 Million by 2020 2Medical Lifting Sling Market Worth USD 706.0 Million by 2020 3Medical Lifting Sling Market Worth USD 706.0 Million by 2020 4Rx Care Management by Proxsys Rx - Transition of Care Technology Helps Prevent Hospital Medication Errors 2Four Mercy Hospitals in Northwest Ohio Select NorthStar Anesthesia 2
... ARAY ), a global leader in the ... has been treated with the CyberKnife ® Robotic ... treatment of both cancerous and non-cancerous tumors anywhere in ... radiosurgery received treatment during Accuray,s fiscal 2010, which ran ...
... an industry leader in the development and implementation ... (PM) solutions,  congratulates  the Diabetes Center of Ocean ... Collins, CO, for their recognition as 2010 HIMSS ... Healthcare Information and Management Systems Society (HIMSS) selected ...
Cached Medicine Technology:100,000th Patient Treated With Accuray's CyberKnife® Robotic Radiosurgery System 2100,000th Patient Treated With Accuray's CyberKnife® Robotic Radiosurgery System 3e-MDs Clients Win HIMSS Davies Awards of Excellence 2e-MDs Clients Win HIMSS Davies Awards of Excellence 3e-MDs Clients Win HIMSS Davies Awards of Excellence 4
(Date:8/27/2015)... ... August 27, 2015 , ... Thriveology Founders, Dr. Carly Letzt Carney and Dr. ... Aging Expo in Denver, Colorado on Saturday, August 29, 2015 at the Marriott DTC, ... outlets as health authorities, and will present a two part seminar entitled, “How to ...
(Date:8/27/2015)... (PRWEB) , ... August 27, 2015 , ... Dr. Jennifer ... be the guest speaker at CURE® magazine’s 3rd Annual MPN Heroes™ recognition event ... Arnold will be among hundreds of attendees honoring eight heroes who have made significant ...
(Date:8/27/2015)... ... August 27, 2015 , ... Zensah®, the ... professional Tennis player for Israel in the Women’s Tennis Association (WTA). Glushko competes ... training and recovery. , With a focus on technology and comfort, Zensah® has ...
(Date:8/27/2015)... ... August 27, 2015 , ... For the ... one machine with the Nutri Ninja® Auto-iQ Pro Complete and Nutri Ninja Auto-iQ ... Technology that takes drink customization to a whole new level. This line of ...
(Date:8/27/2015)... ... August 27, 2015 , ... Sunbelt® Bakery, maker of ... corn syrup, is changing the expectation of how protein bars should taste with the ... unlike any other protein bar on the market today. , The new Protein ...
Breaking Medicine News(10 mins):Health News:Internationally-renowned Naturopathic Doctor and Chiropractor Team up to Reveal Secrets of Avoiding Disease 2Health News:Dr. Jennifer Arnold of ‘The Little Couple’ to Keynote 3rd Annual MPN Heroes™ Recognition Event in Orlando 2Health News:Dr. Jennifer Arnold of ‘The Little Couple’ to Keynote 3rd Annual MPN Heroes™ Recognition Event in Orlando 3Health News:Dr. Jennifer Arnold of ‘The Little Couple’ to Keynote 3rd Annual MPN Heroes™ Recognition Event in Orlando 4Health News:Zensah® Compression Announces Partnership with WTA Tennis Professional Athlete, Julia Glushko 2Health News:Zensah® Compression Announces Partnership with WTA Tennis Professional Athlete, Julia Glushko 3Health News:SharkNinja's Nutri Ninja® Auto-iQ™ Pro Complete Delivers Power And Versatility In A Compact Design 2Health News:SharkNinja's Nutri Ninja® Auto-iQ™ Pro Complete Delivers Power And Versatility In A Compact Design 3Health News:SharkNinja's Nutri Ninja® Auto-iQ™ Pro Complete Delivers Power And Versatility In A Compact Design 4Health News:Sunbelt® Bakery Changes the Expectations of How Protein Bars Should Taste with the Introduction of Its New Protein Delights 2Health News:Sunbelt® Bakery Changes the Expectations of How Protein Bars Should Taste with the Introduction of Its New Protein Delights 3
... 16 Starpharma,Holdings Ltd (ASX: SPL, Pink Sheets: ... SSL International plc (LSE: SSL), owner of Durex(R), ... which a commercial licence will be negotiated,sets out ... coating.,Undisclosed fees are payable to Starpharma under the ...
... College of Chest Physicians for Lung Cancer ... ... Novadaq(R) Technologies Inc.,(TSX: NDQ), a developer of real-time medical imaging systems ... will,launch the PINPOINT(TM) endoscopic imaging system at the Annual Meeting of,American ...
... Association urges citizens to take precautionary steps, DALLAS, ... dangers of winter weather. It,s also a time when ... you have heart disease.,Following are a few tips from ... Flu Every year in the United States, according ...
... During October, Breast ... Cancer Awareness Month, VENTURA, Calif., ... ) has,truly raised the bar for Susan G. Komen for the ... in,a delectably pink breast cancer awareness wrapper, is in retail for ...
... Sales Executive to Lead Growing Medical Device Firm, ... Vascular Inc., a,leading provider of innovative medical devices ... minimally invasive treatment of,deep vein thrombosis (DVT) and ... named Scott Cramer to the position of President ...
... Community-Organization CEOs to Meet with,Members of Congress This ... leadership of,major community-based Hispanic health organizations will converge ... congressional override of President,George W. Bush,s veto of ... Health Insurance Program (SCHIP)., The visits are ...
Cached Medicine News:Health News:Starpharma and Durex Sign Co-Development Agreement for VivaGel(R)-Coated Condoms 2Health News:Novadaq launches PINPOINT: Company's first minimally invasive imaging system 2Health News:Novadaq launches PINPOINT: Company's first minimally invasive imaging system 3Health News:Novadaq launches PINPOINT: Company's first minimally invasive imaging system 4Health News:Cold Weather Can Increase Heart Disease Risks 2Health News:Think Pink for the Cure: thinkproducts Raises Over $50,000 for Breast Cancer Awareness 2Health News:Bacchus Vascular Names Scott Cramer as President and CEO 2Health News:National Alliance for Hispanic Health Ramps Up Lobbying for SCHIP Veto Override 2
... (P-ANCA) is for the specific detection ... myeloperoxidase as antigen. No false-positive results ... elastase in the antigen preparation. MPO ... indirect immunofluorescence; only about 10% of ...
... Inc. (DAI) Myeloperoxidase (MPO) Enzyme-Linked Immunosorbent ... and semi-quantitative determination of IgG, A, M ... assay is used to detect antibodies ... of the assay are to be used ...
... is a solid phase two-site enzyme ... direct sandwich technique in which two ... antigenic determinants on the insulin molecule. ... react with peroxidase-conjugated anti-insulin antibodies and ...
Anti-RSV IgM Assay (ELISA)....
Medicine Products: