Navigation Links
Alfacell's Onconase Highlighted in Latest Edition of Handbook of,Therapeutic Antibodies

BLOOMFIELD, N.J., March 20, 2007 /PRNewswire-FirstCall/ -- Alfacell Corporation's ONCONASE (ranpirnase) has shown potential to act as a potent payload in antibody conjugates for cancer therapy, according to the latest edition of the Handbook of Therapeutic Antibodies.

In a chapter of the text that reviews immunotoxins, Susanna Rybak, Ph.D. summarizes preclinical research indicating that the specificity and potency of ONCONASE improves in a number of tumor models, including non-Hodgkin's lymphoma, when it is conjugated with various antibodies. Dr. Rybak also reviews evidence that implies that ONCONASE may also be effectively targeted to tumors as a conjugate with non-internalizing antibodies, as compared with the internalizing antibodies required by standard plant and bacterial toxins.

"Antibody-targeted ONCONASE is the most potent targeted ribonuclease (RNase) that I have studied," Dr. Rybak said. "While immunotoxins have entered the arsenal of anti-cancer drugs, there have been problems with their clinical use. ONCONASE's excellent performance in preclinical studies makes it a very promising candidate for testing in the clinic."

"It is a great honor to be included in this important industry reference book," added Kuslima Shogen, Alfacell's chairman and chief executive officer. "This work is further evidence of the opportunity that exists for us to build a significant ONCONASE franchise, as a single agent, in combination therapy or as a payload in antibody conjugates. ONCONASE has the potential to be an effective, highly targeted agent for the treatment of various cancers beyond mesothelioma."

For more than 25 years, Dr. Rybak's research has centered on the biology of RNases, antibody engineering and drug targeting. Her laboratory at the National Cancer Institute (NCI) developed the groundwork for RNase-based therapeutics for NHL and breast cancer. Dr. Rybak, who is a member of Alfac
'"/>




Page: 1 2 3 4

Related medicine technology :

1. In Vitro and In Vivo Data Show Alfacells Onocanse is Active Against Naive and Chemoresistant Neuroblastoma Cells
2. Preclinical Data Show Alfacells Onconase Inhibits Tumor Growth of Non-Small Cell Lung Cancer, Breast Cancer Cells
3. Researchers Identify Intracellular Pathway of Alfacells Onconase
4. In vivo Study Results Demonstrating Potential of Alfacells Onconase for Treatment of Non-Small Cell Lung Cancer Published in Anticancer Research
5. Studies Show Mild Hyperthermia Enhances Antitumor Effects of Alfacells Onconase
6. Onconase has Potential as Chemopreventive Agent in Mesothelioma, Reports World-Renowned Mesothelioma Researcher at AACR Annual Meeting
7. Positive Results for Second-Generation Taxus Liberte Coronary Stent System Highlighted in Journal of American College of Cardiology
8. Isotechnikas Lead Drug, ISA247, To Be Highlighted at the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
9. Gentiums Defibrotide Highlighted in Poster Presentation at World Congress of Nephrology
10. Aeolus Pharmaceuticals AEOL 10150 Highlighted in Nature Genetics Publication
11. Gentiums Defibrotide Highlighted in Two Poster Presentations at American Association for Cancer Research Annual Meeting
Post Your Comments:
(Date:12/19/2014)... , December 18, 2014 ... software application/module that is used to store, manipulate, ... RIS comprises a patient tracking and scheduling system, ... integration of RIS with HIS and other databases ... patient registration and patient scheduling, patient list management, ...
(Date:12/19/2014)... , Dec. 18, 2014  Decision Resources Group ... the United States will increase to a ... be primarily driven by expansion in the large direct ... devices will be increasingly adopted due to the advantages ... Other key findings from Decision Resources Group,s coverage ...
(Date:12/19/2014)... , Dec. 18, 2014 Since last month,s ... site now known as the leading online black market ... explosive growth in its offering of drugs and other ... show the takedowns did succeed in lowering the numbers ... review of the markets in August. But some new ...
Breaking Medicine Technology:The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 2The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 3U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 2U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 3Post Silk Road - Another Online Drug Den Now Dominates the DarkNet 2Post Silk Road - Another Online Drug Den Now Dominates the DarkNet 3
... Novelos Therapeutics, Inc. (OTCBB: NVLT) , a pharmaceutical company developing ... the pricing of an underwritten public offering of 9,840,000 units ... unit consists of one share of common stock and a ... will have an exercise price of $0.60 per share and ...
... Thirty years after the start of the HIV/AIDS epidemic, ... work tirelessly to bring relief and hope to those ... as the Foundation for Hospices in Sub-Saharan Africa, is ... those living with HIV/AIDS, focusing primarily on palliative care ...
Cached Medicine Technology:Novelos Therapeutics Prices $5.9 Million Public Offering 2Bringing Pain Management to Africa: Spreading Relief Through Training 2
(Date:12/17/2014)... A group of 127 scientists sent an ... reaction to a recent statement by the center that was ... derogated the efficacy of all brain exercises. , Signatories to ... of the center’s statement critical of brain exercise companies that ... overstated its case, in a document it had entitled “A ...
(Date:12/17/2014)... FL (PRWEB) December 17, 2014 No ... not been able to eradicate the head louse parasite—a ... hassle for parents. Each year between six and twelve ... Troopers, the Miami-based lice removal treatment company comes to ... non-toxic and environmentally friendly. With its track record of ...
(Date:12/17/2014)... Project Veritas is releasing a video interview of ... and Obamacare architect Jonathan Gruber to public attention. Award-winning ... which is being distributed on YouTube. , During the ... the Affordable Care Act in order to hide a ... per year tax grab. , “President Obama promised us ...
(Date:12/17/2014)... Mozes HealthDay Reporter , TUESDAY, ... infectious diseases, one worrisome phenomenon is when an illness that ... -- known as zoonosis -- is not uncommon and keeps ... an animal-borne disease might make inroads into the human population. ... -- and the culprits in this case were guinea pigs. ...
(Date:12/17/2014)... News) -- Poor students get more fruits and vegetables at ... But, the opposite is true for students from wealthier ... at school may give a healthy boost to poor students, ... the family income level, students all ate a similar amount ... The study was published recently in the journal Preventive ...
Breaking Medicine News(10 mins):Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 2Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 3Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 4Health News:Lice Troopers Announces New Lice Treatment Clinic in Coral Gables to Service Key Biscayne, Coconut Grove, Kendall, Brickell & South Miami 2Health News:Project Veritas: James O’Keefe Interviews the Man Who Discovered Jonathan Gruber Videos 2Health News:Guinea Pigs Can Be Source of Serious Strep Infection 2Health News:Guinea Pigs Can Be Source of Serious Strep Infection 3Health News:Poor Students Eat Healthier Foods at School, Study Finds 2
... , , NASHVILLE, Tenn., ... and payment cycle management solutions for the healthcare industry, ... implemented the Emdeon Patient Responsibility Estimator(SM) solution. Emdeon Patient ... BroMenn,s patient access staff to inform patients of their ...
... , , PISCATAWAY, ... Board: MLSS), the recognized leader in advanced injection technologies, ... Office has issued a Notice of Allowance for Milestone,s ... disposable hand piece for fluid administration. Milestone,s proprietary, ...
... , , WACO, Texas, Aug. 24 ... out a universal health care plan in their new book ... published by Cambridge University Press, that does not create a ... coverage or health care of Americans who currently have coverage. ...
... , BERKELEY HEIGHTS, N.J., Aug. 24 Authentidate ... of secure Health Information Exchange and workflow management services, today ... of home healthcare services and medical equipment, selected Authentidate,s Inscrybe(TM) ... physicians. , , "We believe that Inscrybe ...
... Boost Your Local Blood Supply , , ... its regional operations in Manhattan, Long Island, Hudson Valley, Brooklyn / ... blood now through Labor Day to help ensure that your community ... NYBC also asks that people who have donated blood once in ...
... , , ... Inc., announced today that it has received European CE Mark ... System. The device is now approved for use in improving ... disease. , , The novel vProtect(TM) Luminal ...
Cached Medicine News:Health News:Emdeon and BroMenn Healthcare System Take the Lead on Consumer Price Transparency 2Health News:Emdeon and BroMenn Healthcare System Take the Lead on Consumer Price Transparency 3Health News:Emdeon and BroMenn Healthcare System Take the Lead on Consumer Price Transparency 4Health News:Milestone Scientific Announces Notice of Allowance From US Patent and Trademark Office 2Health News:Milestone Scientific Announces Notice of Allowance From US Patent and Trademark Office 3Health News:Baylor University Economists Call for Different Tack on Health Care Insurance 2Health News:LifeCare Solutions Simplifies Healthcare Order Process Management with Authentidate's Inscrybe Healthcare 2Health News:LifeCare Solutions Simplifies Healthcare Order Process Management with Authentidate's Inscrybe Healthcare 3Health News:LifeCare Solutions Simplifies Healthcare Order Process Management with Authentidate's Inscrybe Healthcare 4Health News:Give Blood Today for Community Preparedness 2Health News:Give Blood Today for Community Preparedness 3Health News:vProtect Luminal Shield (TM) from Prescient Medical Receives CE Mark 2
... Chemstrip Micral test strips are an ... in urine samples. When the test ... sample, urine passes via a wick ... albumin present in the sample binds ...
The A350 test is used for POC testing in hospital emergency departments, replacing the need to draw blood for alcohol testing. Each hash mark is 0.02% or 20 mg/dL....
AccuSign DOA Series tests include tests for Amphetamines, Barbituates, Benzodiazepines, Cocaine, Methadone, Methamphetamines, Nicotine (Cotinine), Opiates, Phencyclidine, THC, Tricyclic Antidepressan...
... drugs of abuse tests are highly accurate in ... recommended cut-off as confirmed by GC/MS testing. This ... specific alternative method (such as GC/MS) must be ... Professional judgment should be applied to any drug ...
Medicine Products: