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Alchemia Reports Preliminary Positive Efficacy Data From HyCAMP,Phase II Trial

Progression Free Survival 6. Median Overall Survival 7. 50% or greater decline in CEA levels 8. Time to treatment failure Study Results Study Results Patient demographics Control HyCAMP(TM) Overall (n = 35) (n = 41) (n = 76) Sex Male 21 (60.0) 24 (58.5) 45 (59.2) Female 14 (40.0) 17 (41.5) 31 (40.8) Age (Years) n 35 41 76 Median 63.11 62.30 62.67 ECOG Status 0 16 19 45 1 19 22 31 Prior oxaliplatin therapy n 30 34 64 Primary Endpoint 1. Incidence of grade 3 or 4 diarrhoea in HyCAMP(TM) arm versus irinotecan arm. The overall incidence of Grade 3/4 diarrhoea (14%) was much lower than anticipated (30%) making analyses of this end point futile. There was no statistically significant difference in the incidence of grade 3 or 4 diarrhea in the HyCAMP(TM) arm versus the irinotecan arm. Secondary safety endpoints 1. Incidence of grade 3 or 4 diarrhoea in cycle 1 or cycle 2 see comment above for primary end-point all but one case of diarrhoea occurred in Cycle 1 2. Requirement for dose reduction for any cause after 2 cycles of therapy to be determined 3. Requirement for dose reduction for any reason to be determined 4. Overall incidence of grade 3 or 4 neutropenia to be determined 5. Overall adverse events - no major differences between treatment arms Secondary Efficacy Endpoints 1. Number of patients completing two cycles of therapy 38 of 41 (93%) HyCAMP(TM) patients compared to 2
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